Cockroach extract, and preparation method and use thereof

A technology of extract and cockroach, applied in the field of cockroach extract and its preparation, can solve the problem of inactivity of Gram-negative bacteria

Active Publication Date: 2015-09-30
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are fewer literature reports related to cockroach antibacterial activity. Among them, people such as Wang Kui found that after Periplaneta americana was extracted with petroleum ether, the petroleum ether layer was discarded, and the ethyl acetate extract of its dregs was the antibacterial agent of Peripl

Method used

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  • Cockroach extract, and preparation method and use thereof
  • Cockroach extract, and preparation method and use thereof
  • Cockroach extract, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0024] The preparation of embodiment 1 American cockroach extract

[0025] Take Periplaneta americana, crush it to the coarsest powder, add 8 times the amount of petroleum ether (60-90°C) to reflux and extract for 3 times, extract for 1 hour each time, combine the extracts, recover petroleum ether, and dry to obtain Periplaneta americana extract things. The preparation of embodiment 2 Australian cockroach extract

Embodiment 2

[0026] Take the Australian cockroach, crush it to the coarsest powder, add 6 times the amount of petroleum ether (60-90°C) to reflux and extract for 3 times, combine the extracts, extract for the first time for 1.5 hours, and extract the rest for 1 hour for the second time. After recovering the petroleum ether, Dry to obtain the Periplaneta australasia extract.

Embodiment 3

[0027] The preparation of embodiment 3 Blattella texas extract

[0028] Take Blattella texas, crush it to the coarsest powder, add 10 times the amount of petroleum ether to reflux (60-90°C) and extract twice, each time for 1.5 hours, combine the extracts, recover petroleum ether, and dry to obtain Blattella texas Extract.

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Abstract

The invention discloses an antibacterial active part of a cockroach, and an extraction method and use thereof. Researches in the invention unexpectedly find that a petroleum ether extraction part of the cockroach has good inhibitory activity to both tested gram-positive bacterium and gram-negative bacterium; furthermore, the activity of the petroleum ether extraction part of the cockroach is obviously prior to that of an ethyl acetate extraction part; and an n-butyl alcohol extraction part and a 95% v/v ethanol extraction part do not have obvious antibacterial activity.

Description

technical field [0001] The invention relates to a cockroach extract, a preparation method and application thereof. Background technique [0002] Cockroach, recorded in "Shen Nong's Materia Medica", "Famous Doctors", "Compendium of Materia Medica" and other medical books, tastes salty, cold in nature, has the effects of dispelling blood stasis, dissolving accumulation, and detoxifying. It is a traditional medicinal insect [1] . Modern pharmacological studies have shown that cockroaches can promote vascular proliferation, tissue repair, strengthen the heart, improve microcirculation, antibacterial, anti-inflammatory, antiviral, antitumor, and enhance immunity. [2] . In recent years, there have been more and more studies on the medicinal value of cockroaches, and the clinical application of its preparations has become more and more extensive, showing great application prospects in the field of medicine. [0003] At present, research on the activity of cockroaches mainly foc...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P31/04
CPCY02A50/30
Inventor 王达宾李希冯建安李远辉邹俊波苏柘僮
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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