Pharmaceutical composition and preparation method, preparation and application thereof

A composition and drug technology, applied in the field of pharmaceutical composition and its preparation, can solve the problems of inability to prevent disease development, single action target, and large toxic and side effects, and achieve the prevention and treatment of senile dementia, simple preparation method, and small toxic and side effects Effect

Inactive Publication Date: 2015-09-30
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The current drugs for the treatment of Alzheimer's disease are mainly cholinesterase inhibitors such as Donepagil Hydrochloride (Aricept), Carbaladin Bitartrate (Exelon), Huperzine A (Huperzine), and Lantamine (galantamine), etc., these drugs can only improve the symptoms of dementia patients, but can not prevent the development of the disease, there is a single target of action, poor curative effect, long-lasting effect, large toxic and side effects, etc.

Method used

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  • Pharmaceutical composition and preparation method, preparation and application thereof
  • Pharmaceutical composition and preparation method, preparation and application thereof
  • Pharmaceutical composition and preparation method, preparation and application thereof

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preparation example Construction

[0022] The preparation method of the pharmaceutical composition of the present invention comprises the following steps:

[0023] A, take by weighing the Ginkgo biloba and Herba huixincao of formula quantity, pulverize and sieve, extract and obtain Ginkgo biloba and huixincao extract;

[0024] B, take the dragon's blood jelly and Gastrodia elata of formula quantity, pulverize and sieve for subsequent use;

[0025] C. Merge the Ginkgo biloba and Herba huixincao extracts extracted in step A with the dried dragon's blood and Gastrodia elata crushed and sieved in step B, mix evenly, and ultrafinely pulverize to obtain the target substance.

[0026] Pulverize and sieve in A step to cross 10 mesh sieves.

[0027] The extraction described in the A step is percolation extraction.

[0028] The extraction is to add an ethanol solution with a volume percentage concentration of 70-80% of the volume percentage of 8-10 times the solid-liquid volume ratio to the crushed and sieved ginkgo le...

Embodiment 1

[0039] Pharmaceutical composition 1 and its preparation method (dragon's blood, ginkgo biloba, gastrodia elata, and huixincao in a ratio of 6:4:1:1)

[0040] Drug prescription: 30 kg of dragon's blood, 20 kg of ginkgo biloba, 5 kg of gastrodia elata, 5 kg of huixincao. (6:4:1:1)

[0041] Preparation:

[0042] (1) Weigh 20 kg of Ginkgo biloba leaves and 5 kg of Ginkgo biloba, grind them to the coarsest powder (through a 10-mesh sieve), add 250 kg of 75% ethanol, soak at room temperature for 8 hours, put them into a percolator, and add 1000 kg of Carry out percolation with 75% ethanol, collect the percolation liquid, spray powder and dry it under vacuum at 40-50°C, and obtain dry powder of Ginkgo biloba and Cortex reminiscent extracts (A) for later use;

[0043] (2) Weigh 30 kg of dragon's blood and 5 kg of Gastrodia elata, pulverize them with a grinder, and pass through a 10-mesh sieve to obtain dragon's blood and Gastrodia elata powder (B) for later use;

[0044] (3) The ab...

Embodiment 2

[0046] Pharmaceutical composition 2 and its preparation method (dragon's blood, ginkgo biloba, gastrodia elata, and huixincao in a ratio of 6:6:1:2)

[0047] Drug prescription: 30kg of dried blood, 30kg of ginkgo biloba, 5kg of gastrodia elata, 10kg of huixincao. (6:6:1:2)

[0048] Preparation:

[0049](1) Weigh 30 kg of Ginkgo biloba leaves and 10 kg of Ginkgo biloba, grind them to the coarsest powder (through a 10-mesh sieve), add 320 kg of 75% ethanol, soak at room temperature for 8 hours, put them into a percolator, and add 1200 kg of Carry out percolation with 75% ethanol, collect the percolation liquid, spray powder and dry it under vacuum at 40-50°C, and obtain the dry powder of Ginkgo biloba and Cortex reminiscent extracts (A) for later use;

[0050] (2) Weigh 30 kg of dragon's blood and 5 kg of Gastrodia elata, pulverize them with a grinder, and pass through a 10-mesh sieve to obtain dragon's blood and Gastrodia elata powder (B) for later use;

[0051] (3) The abov...

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Abstract

The invention discloses a pharmaceutical composition and a preparation method, a preparation and application thereof. The pharmaceutical composition consists of the following materials in parts by weight: 30-40 parts of resina draconis, 20-30 parts of folium ginkgo, 5-10 parts of rhizoma gastrodiae and 5-10 parts of rhodobryum roseum limp. The preparation method comprises the following steps: crushing and sieving folium ginkgo and rhodobryum roseum limp, and extracting to obtain a folium ginkgo and rhodobryum roseum limp extract; crushing and sieving resina draconis and rhizoma gastrodiae for later use; merging the folium ginkgo and rhodobryum roseum limp extract with resina draconis and rhizoma gastrodiae, uniformly mixing, and conducting superfine grinding to obtain the target object. The preparation is powder, tablets, capsules, particles, drop pills or honeyed pills, prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition. The pharmaceutical composition is applied to preparation of medicines for treating AD. The pharmaceutical composition has the functions of invigorating qi and blood, dispersing blood stasis and relieving depression, restoring consciousness and easing mental stress, improving sleep and preventing and curing AD, has the characteristics of good effect, less toxic or side effects, simple and convenient preparation method and the like, and is suitable for clinical popularization and application.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicine composition and its preparation method, preparation and application. Background technique [0002] Senile dementia, also known as Alzheimer's disease, is a disease caused by chronic progressive central nervous system lesions. Mental symptoms are characteristic. The incidence of senile dementia increases with age, the prevalence rate is 5-10% for those over 65 years old, and 20-50% for those over 85 years old. With the aging of my country's population, the incidence of Alzheimer's disease is on the rise. The current drugs for the treatment of Alzheimer's disease are mainly cholinesterase inhibitors such as Donepagil Hydrochloride (Aricept), Carbaladin Bitartrate (Exelon), Huperzine A (Huperzine), and These drugs, such as galantamine, can only improve the symptoms of dementia patients, but cannot prevent the development of the disease. They have problems...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/28
Inventor 周荣光杨兆祥赵加强
Owner KPC PHARM INC
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