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A kind of 125i radiation microsphere, its preparation method and microfluidic device

A technology of microspheres and spherical shells, applied in the field of radiation medicine, can solve the problems of low utilization rate of raw materials, expensive carrier materials, uneconomical and other problems, and achieve the effects of short time consumption, high yield and low cost

Active Publication Date: 2018-08-21
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In traditional adsorption methods, 125 The I nuclide is adsorbed on the surface of the above carrier, 125 The efficiency of I nuclide adsorption is low, resulting in a low utilization rate of its raw materials. At the same time, due to the high cost of carrier materials, the traditional adsorption method is uneconomical.

Method used

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  • A kind of 125i radiation microsphere, its preparation method and microfluidic device
  • A kind of 125i radiation microsphere, its preparation method and microfluidic device
  • A kind of 125i radiation microsphere, its preparation method and microfluidic device

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preparation example Construction

[0049] The present invention also provides a 125 The preparation method of 1 radiation microsphere comprises the following steps:

[0050] A) the capsule core phase solution and the capsule wall phase solution are merged to obtain the capsule wall phase solution wrapped around the capsule core phase liquid droplet; the capsule core phase solution includes 125 The solution of I, the capsule wall phase solution comprises tripropylene glycol diacrylate solution containing paclitaxel;

[0051] B) The capsule wall phase solution wrapped around the gel core phase droplet is merged with the continuous phase solution to obtain the capsule wall phase droplet wrapped around the gel core phase droplet, and the continuous phase solution includes simethicone, kerosene and one or more of liquid paraffin;

[0052] C) solidifying the capsule wall phase droplets wrapped around the glue core phase droplets to obtain 125 I Radiation Microspheres.

[0053] In the present invention, the gelati...

Embodiment 1

[0089] Take 2.76g deionized water and 0.24g containing 5mCi radioactive 125 Mix I nuclides with NaI, stir and dissolve with a glass rod, and make a colloidal nucleus phase solution.

[0090] Take 0.4g of paclitaxel (HCPK) and 9.6g of tripropylene glycol diacrylate (TPGDA) and mix them, stir them with magnetic force to dissolve, and make a cystic wall phase solution.

[0091] Take simethicone as the continuous phase solution.

[0092] Fill the above-mentioned core phase, capsule wall phase and continuous phase solutions into 1mL, 20mL and 20mL syringes, respectively, and place them on the corresponding syringe pumps, and connect to the microfluidic device. Set the flow rate of the glue core phase solution to 0.5 μL / min, the flow rate of the cyst wall phase solution to 3.5 μL / min, and the flow rate of the continuous phase solution to 120 μL / min. The size of the capillary of the colloid core phase is: inner diameter / outer diameter 100 μm / 167 μm, and the size of the capillary tu...

Embodiment 2

[0095] Take 1.82g deionized water and 0.18g containing 7mCi radioactive 125 Mix I nuclides with NaI, stir and dissolve with a glass rod, and make a colloidal nucleus phase solution.

[0096] Take 0.4g of paclitaxel (HCPK) and 9.6g of tripropylene glycol diacrylate (TPGDA) and mix them, stir them with magnetic force to dissolve, and make a cystic wall phase solution.

[0097] Take simethicone as the continuous phase solution.

[0098] Fill the above-mentioned core phase, capsule wall phase and continuous phase solutions into 1mL, 20mL and 20mL syringes, respectively, and place them on the corresponding syringe pumps, and connect to the microfluidic device. Set the flow rate of the glue core phase solution to 0.25 μL / min, the flow rate of the cyst wall phase solution to 3.75 μL / min, and the flow rate of the continuous phase solution to 120 μL / min. The size of the capillary of the colloid core phase is: inner diameter / outer diameter 100 μm / 167 μm, and the size of the capillary ...

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Abstract

The invention provides a 125I radioactive microsphere. The 125I radioactive microsphere comprises a sphere shell and a solution which contains 125I and is wrapped in the sphere shell. The sphere shell is made of materials which comprise paclitaxel and tripropylene glycol dipropyl acrylate. The 125I radioactive microsphere is stable in structure, and compared with adsorption carriers used in a traditional adsorption method, raw materials adopted by the 125I radioactive microsphere are more economical; meanwhile, due to the fact that radioactive 125I nuclide is wrapped in the sphere shell of the microsphere, the utilization efficiency of the 125I radioactive microsphere is close to 100 percent and higher than that of the traditional adsorption method. The invention further provides a preparation method for the 125I microsphere and a microflow device. By adjusting the flow of a colloidal nucleus phase, a capsule wall phase and a continuous phase, the accurate controllability of the 125I radioactive microsphere particle size is achieved. Compared with the traditional method which is more prone to being influenced by experimental environment factors, the controllability of the 125I radioactive microsphere and the preparation method thereof and the microflow device is high.

Description

technical field [0001] The invention belongs to the technical field of radiation medicine, in particular to a 125 I Radiation microspheres, their preparation method and microfluidic device. Background technique [0002] Radiation therapy (referred to as radiotherapy) kills tumor cells by the radiation emitted by radioactive particles. As an effective means of treating tumors and cancers, radiotherapy is widely used. The disadvantage of radiotherapy is that while killing tumor cells, it will also cause damage to normal cells, thereby threatening human life. [0003] In recent years, radioactive seed implantation as a new treatment method has gradually become a research hotspot. Among them, close-range radiation 125 I seed source has been widely used in the treatment of malignant tumors, especially the treatment of prostate cancer, lung cancer and brain cancer. Under the condition of the three-dimensional radiotherapy system, the miniature, certain specifications and moder...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/12A61K51/06B01J13/02A61P35/00A61K101/02
Inventor 常振旗张淼
Owner UNIV OF SCI & TECH OF CHINA
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