Use of compound P7C3-A20 in preparation of drug for treating cerebral ischemic diseases

A P7C3-A20, a technology for preparing medicines, which is applied in the application field of preparing medicines for treating cerebral ischemia, can solve the problem that there is no protective effect of P7C3-A20 on cerebral ischemic injury, and achieves reduction of cerebral infarction area and wide application. Prospects, the effect of improving the survival rate
CN104997771AActive Publication Date: 2015-10-28SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2015-10-28

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Abstract

The invention relates to a use of a compound P7C3-A20 in preparation of a drug for treating cerebral ischemic diseases. A cell experiment proves that P7C3-A20 can improve a survival rate of mouse cerebral cortical neurons cultured in vitro in an oxygen-glucose deprivation model. An animal experiment proves that P7C3-A20 can obviously reduce the area of cerebral infarction caused by rat brain retinal artery occlusion. The above results show that P7C3-A20 has cerebral ischemia protection effects, can prevent and treat cerebral ischemia-caused brain damage and has a wide application prospect in preparation of cerebral ischemic injury and / or cerebral infarction-related drugs.
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Description

technical field

[0001] The present invention relates to a new application of the compound, in particular to the application of the compound P7C3-A20 in the preparation of a drug for treating cerebral ischemic diseases. Background technique

[0002] P7C3-A20 is one of the P7C3 series compounds, the CAS number is 1235481-90-9, and the chemical structural formula is:

[0003]

[0004] It is a chloropropylcarbazole compound with high oral bioavailability, crosses the blood-brain barrier, and exhibits no toxicity at both effective and high doses. Foreign reports have found that P7C3 compounds have protective effects in depression, senile diseases such as Parkinson's (PD), amyotrophic lateral sclerosis (ALS), cognitive degenerative diseases, retinal degeneration and other diseases . At present, there is no report on the protective effect of P7C3-A20 on cerebral ischemic injury. Contents of the invention

[0005] The purpose of the present invention is to provide a new appl...

Claims

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