Long-acting non-water-carrier injection liquid and preparing method thereof

Abstract

The invention discloses long-acting non-water-carrier injection liquid and a preparing method thereof. The long-acting non-water-carrier injection liquid comprises mental drugs and non-water carriers and can be continuously released within at least four weeks. The mental drugs are lauroyl aripiprazole or paliperidone palmitate. The preparing method is completed through high-pressure homogeneous steps. The preparation of the long-acting non-water-carrier injection liquid can be released slowly within at least four weeks. The continuously-releasing injection preparation is more stable, simple in preparation form, free of freeze drying, simple in preparation, good in economical effect and convenient to use.

Description

technical field [0001] The invention relates to chemistry, in particular to a long-acting non-aqueous carrier injection and a preparation method thereof. Background technique [0002] Since mental illnesses such as schizophrenia require long-term medication, patient compliance is poor, and long-acting injections for two weeks or longer have shown great advantages in the treatment of such diseases. [0003] The long-acting preparations currently on the market include the suspension freeze-dried preparation of aripiprazole from Japan's Otsuka Pharmaceutical Co., Ltd., and the paliperidone palmitate sustained-release long-acting injection of the American Janssen Pharmaceutical Co., Ltd. Da, the English product name is )Wait. Among them, Paliperidone Palmitate Sustained-release Long-acting Injection was launched in the United States on July 31, 2009. It is currently the only one in China that can not only act quickly in the acute phase but also effectively prevent recurrence ...

AI Technical Summary

Problems solved by technology

Aqueous nano-suspensions have problems such as slowly increasing particle size, difficulty in aseptic control, and expensive equipment

[0012] Aripiprazole lauroyl and paliperidone palmitate are insoluble in water. To make an aqueous carrier nanosuspension, injection-grade carboxymethylcellulose is required. There is no related product in China at present.

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