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2,3-double benzimidazole pyridine cobalt (II) coordination compound and application thereof in pharmacy

A technology of benzimidazole pyridine cobalt and complexes, applied in cobalt organic compounds, compounds containing elements of group 8/9/10/18 of the periodic table, organic chemistry, etc., can solve the problem of drug resistance of tumor cells, the have serious side effects, etc.

Inactive Publication Date: 2015-11-04
GUANGXI MEDICAL UNIVERSITY
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  • Abstract
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Problems solved by technology

[0002] In the current cancer treatment, the use of platinum-based anticancer drugs accounts for 70% of anticancer drugs, and the representative drug cisplatin can effectively treat a variety of cancers and is the most effective anticancer drug for testicular and ovarian cancer. One, but it also has certain limitations, it is easy to produce drug resistance in tumor cells, and has serious side effects on the body, such as nausea, diarrhea, kidney and liver failure, etc.

Method used

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  • 2,3-double benzimidazole pyridine cobalt (II) coordination compound and application thereof in pharmacy
  • 2,3-double benzimidazole pyridine cobalt (II) coordination compound and application thereof in pharmacy
  • 2,3-double benzimidazole pyridine cobalt (II) coordination compound and application thereof in pharmacy

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Embodiment Construction

[0018] The technical solutions of the present invention will be further described below in conjunction with specific embodiments of the accompanying drawings.

[0019] 1. 2,3 bisbenzimidazole pyridine cobalt (II) complexes (C 38 h 24 CoN 10 ) preparation

[0020] CoCl 2 ·6H 2 O 0.1189g (0.5mmol) aqueous solution (5mL) was added to 2,3-bisbenzimidazole pyridine 0.0770g (0.25mmol) in DMF solution (3mL) and stirred for reaction for 3min, then added concentrated ammonia 5mL and stirred for 30s, Transfer to a high-pressure reactor and react at 180°C for 2 days. At the end of the reaction, drop to room temperature with a rate gradient of 5°C / h, filter, and wash with deionized water to obtain dark purple blocky crystals.

[0021] 2. Infrared spectrum detection

[0022] The complex is pressed with KBr at 4000-400cm -1 Range determination infrared spectrum, such as Figure 7 shown.

[0023] 3. Crystal Structure Determination

[0024] The crystals with suitable dimensions, no ...

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Abstract

The invention discloses a 2,3-double benzimidazole pyridine cobalt (II) coordination compound. The crystal structure of the compound belongs to a triclinic system, the space group of the compound is P1, and the molecular formula is C[38]H[24]CoN[10]. Co (II) atoms are penta-coordinated. The invention further discloses the application of the 2,3-double benzimidazole pyridine cobalt (II) coordination compound in pharmacy. The 2,3-double benzimidazole pyridine cobalt (II) coordination compound can restrain the growth of human hepatoma carcinoma cells Hep-G2, induce the apoptosis of the human hepatoma carcinoma cells Hep-G2, preventing the human hepatoma carcinoma cells Hep-G2 from being in the G2 phase and affect on DNA in a non-classical insertion mode.

Description

technical field [0001] The invention relates to a 2,3-bisbenzimidazole pyridine cobalt (II) complex and its application in pharmacy. Background technique [0002] In the current cancer treatment, the use of platinum-based anticancer drugs accounts for 70% of anticancer drugs, and the representative drug cisplatin can effectively treat a variety of cancers and is the most effective anticancer drug for testicular and ovarian cancer. One, but it also has certain limitations, it is easy to produce drug resistance in tumor cells, and has serious side effects on the body, such as nausea, diarrhea, kidney and liver failure, etc. Therefore, there is an urgent need to develop anti-cancer drugs that are more effective, less toxic or have DNA-targeted binding. Cobalt is an essential trace element for the human body. It participates in the synthesis of vitamin B12 in the body, stimulates bone marrow hematopoiesis, regulates red blood cell metabolism and other important physiological fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/06C07D401/14A61P35/00
CPCC07B2200/13C07D401/14C07F15/065
Inventor 蒙法艳李雪华林娟娟周锐黄燕军韦毅铭吴妮妮王警杨艳芳邓诗发邓敏罗晶李洁钘
Owner GUANGXI MEDICAL UNIVERSITY
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