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Active component for treating prostatic hyperplasia, and medicine thereof

A technology of prostatic hyperplasia and active ingredients, which is applied in the field of traditional Chinese medicine, can solve the problems of unsatisfactory therapeutic effect of prostatic hyperplasia, large toxic and side effects, etc., and achieve the effect of reducing the wet weight of the prostate, less toxic and side effects, and obvious effects

Inactive Publication Date: 2015-11-11
杨安平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But above-mentioned medicine is not ideal enough to the therapeutic effect of benign prostatic hyperplasia, moreover, existing therapeutic medicine is western medicine mostly, and side effect is big.

Method used

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  • Active component for treating prostatic hyperplasia, and medicine thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take feces-based medicinal materials and grind them, add 60% ethanol according to the ratio of material to liquid 1:6, heat and extract once at 90°C, extract for 1.5 hours, filter to obtain the extract, and concentrate under reduced pressure to obtain the extract;

[0047] Take the extract and suspend it with water, put D101 macroporous resin on the water suspension, use water, 30% ethanol, 55% ethanol and 90% ethanol to elute respectively, and collect the eluate in sections;

[0048] Take the 55% ethanol eluted part and concentrate to obtain the extract;

[0049] Take the extract and dissolve it in methanol, mix well according to the ratio of sample: silica gel = 1:2, remove the solvent, then evenly add the silica gel containing the sample to the top of the silica gel chromatography column, and carry out gradient elution with chloroform: methanol , the gradient concentration is from 20:1 to 1:1, the eluate is collected in equal parts, and the acetic anhydride-concentra...

Embodiment 2

[0051] Take feces-based medicinal materials and grind them, add 60% ethanol according to the ratio of material to liquid 1:8, heat and extract twice at 90°C, extract for 1.0 hour, filter to obtain the extract, and concentrate under reduced pressure to obtain the extract;

[0052] Take the extract and suspend it with water, put D101 macroporous resin on the water suspension, use water, 30% ethanol, 60% ethanol and 95% ethanol to elute respectively, and collect the eluate in sections;

[0053] Take the eluted part of 60% ethanol and concentrate to obtain the extract;

[0054] Take the extract and dissolve it in methanol, mix well according to the ratio of sample: silica gel = 1:3, remove the solvent, then evenly add the silica gel containing the sample to the top of the silica gel chromatography column, and carry out gradient elution with chloroform: methanol , the gradient concentration is from 20:1 to 1:1, the eluate is collected in equal parts, and the acetic anhydride-concen...

Embodiment 3

[0056] Take feces-based medicinal materials and pulverize them, add 60% ethanol according to the ratio of material to liquid 1:10, heat and extract at 90°C for 3 times, extract for 1.0 hour, filter to obtain the extract, and concentrate under reduced pressure to obtain the extract;

[0057] Take the extract and suspend it with water, put D101 macroporous resin on the water suspension, use water, 35% ethanol, 65% ethanol and 95% ethanol to elute respectively, and collect the eluate in sections;

[0058] Take the eluted part of 65% ethanol and concentrate to obtain the extract;

[0059] Take the extract and dissolve it in methanol, mix well according to the ratio of sample: silica gel = 1:2, remove the solvent, then evenly add the silica gel containing the sample to the top of the silica gel chromatography column, and carry out gradient elution with chloroform: methanol , the gradient concentration is from 20:1 to 1:1, the eluate is collected in equal parts, and the acetic anhyd...

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Abstract

The invention discloses an active component for treating prostatic hyperplasia. The active component is beta-sitosterol-3-O-beta-D-glucoside, and is prepared through extracting a Long Stephania Herb medicinal material by using ethanol, and separating and purifying by using macro-porous resin and silica gel. The invention also discloses a medicine for treating prostatic hyperplasia. The medicine contains the active component. The beta-sitosterol-3-O-beta-D-glucoside can obviously reduce the prostate wet weight, the prostate volume and the prostate index of prostatic hyperplasia mice, has an obvious prostatic hyperplasia treatment effect, and has small toxic side effects.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to an active ingredient and medicine for treating benign prostatic hyperplasia. Background technique [0002] Prostatic hyperplasia (BPH) is one of the common diseases of middle-aged and elderly men, and its incidence is increasing with the aging of the global population. The incidence of benign prostatic hyperplasia increases with age, but there may not be clinical symptoms when there are hyperplasia lesions. The urban incidence rate is higher than that in the rural areas, and racial differences also affect the degree of proliferation. There are many studies on the pathogenesis of benign prostatic hyperplasia, but the etiology has not yet been elucidated. It is known that benign prostatic hyperplasia must have two conditions: functioning testis and increasing age. In recent years, we have also noticed the relationship between smoking, obesity and alcoholism, family h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P13/08A61K36/59
Inventor 杨安平
Owner 杨安平
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