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Sophora alopecuroides oral liquid and preparing method thereof

A technology of bitter beans and oral liquid, which is applied in the field of traditional Chinese veterinary medicine, can solve the problems of serious side effects, difficult metabolism of chemical drugs, food safety threats, etc., and achieve the effect of improving the extraction and transfer rate, significant effect, and removal of interfering components

Active Publication Date: 2015-11-11
BAODING JIZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To treat the disease, it is necessary to feed a large amount of chemical drugs such as antibiotics and digestive gland secretion inhibitors to inhibit the growth of mold, and these drugs have serious side effects, often affecting the normal feeding and drinking of chicks, which seriously affects the production performance of chicks, and these Chemical drugs are difficult to metabolize, and also pose a potential threat to human food safety due to accumulation in the food chain

Method used

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  • Sophora alopecuroides oral liquid and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step 1. Stir-frying: Weigh 100g of the seeds of Sophora alopecuroides, and fry them at 170°C for 5 minutes; at this time, the skin cracks and there is a burnt aroma:

[0031] Step 2, extraction: crush the fried bitter beans described in step 1, pass through a 20-mesh sieve, add 10 mL of water to 1 g of bitter beans, add 1000 mL of water, decoct and extract in boiling water at 100 ° C for 3 times ( The amount of Sophora sophora and water in each extraction process is 1g Sophora sophora corresponds to 10mL water), 30min each time; combine the extracts three times, cool the extracts below 40°C, let stand, pass through a 500-mesh filter cloth, The filtrate was then concentrated to a relative density of 1.20 to obtain a concentrated solution (100 mL);

[0032] Step 3, alcohol precipitation: add dehydrated ethanol to the concentrated solution obtained in step 2 until the mass concentration of ethanol in the solution is 50%. At this time, the total amount of dehydrated ethanol...

Embodiment 2

[0035] Step 1. Stir-frying: Weigh 100g of the seeds of Sophora alopecuroides, and fry them at 180°C for 5 minutes; at this time, the skin cracks and there is a burnt aroma;

[0036] Step 2, extraction: crush the fried bitter beans described in step 1, pass through a 20-mesh sieve, add 10 mL of water to 1 g of bitter beans, add 1000 mL of water, decoct and extract in boiling water at 100 ° C for 3 times ( The amount of Sophora sophora and water in each extraction process is 1g Sophora sophora corresponds to 10mL water), 30min each time; combine the extracts three times, cool the extracts below 40°C, let stand, pass through a 500-mesh filter cloth, The filtrate was then concentrated to a relative density of 1.20 to obtain a concentrated solution (100 mL);

[0037] Step 3, alcohol precipitation: add dehydrated ethanol to the concentrated solution obtained in step 2 until the mass concentration of ethanol in the solution is 50%. At this time, the total amount of dehydrated ethanol...

Embodiment 3

[0040] The quality control standard of the Sophora Sophora Oral Liquid prepared in Example 1 or Example 2 is: every 1 mL of liquid medicine is equivalent to 1 g of the raw medicinal material of Sophora Sophora Sophorae.

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Abstract

The invention relates to sophora alopecuroides oral liquid and a preparing method thereof. The oral liquid is prepared through the following steps of 1, stir-frying, wherein seeds of sophora alopecuroides are stir-fried; 2, extraction, wherein the stir-fried sophora alopecuroides is crushed and sieved, then water is added, the crushed sophora alopecuroides is decocted and extracted 2-3 times, extraction liquid is blended and cooled to below 40 DEG C, stands still and is filtered, and concentration liquid is obtained after the filtered liquid is concentrated; 3, ethanol precipitation, wherein absolute ethyl alcohol is added to the concentration liquid, then the mixture is cooled to 0 DEG C-10 DEG C, stands still and is filtered, after ethyl alcohol is removed out of the filtered liquid, the pH value is adjusted to 4.5-6.0, and medical liquid is obtained; and 4, concentration adjusting, filling and sterilization, wherein filling and sterilization are conducted after water is added to the medical liquid to adjust the concentration of the chemical liquid, and the oral liquid is obtained. By means of the oral liquid, water intake and food consumption of chicks are not affected, the content of the effective ingredient sophocarpidine is high, and the effect on treating mycotic ingluvitis, proventriculitis and ventriculitis of chicks is obvious.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese veterinary medicine, and in particular relates to Sophora Sophora Oral Liquid and a preparation method thereof. Background technique [0002] The temperature of the growing environment for 1-14-day-old chicks is 30-35°C, and the relative humidity is 70%-80%, which is very suitable for the growth and spread of mold, while the chicks have weak defense ability and are vulnerable to mold attack, and moldy crops will appear. Inflammation, glandular gastritis, muscle gastritis. To treat the disease, it is necessary to feed a large amount of chemical drugs such as antibiotics and digestive gland secretion inhibitors to inhibit the growth of mold, and these drugs have serious side effects, which often affect the normal feeding and drinking of chicks and seriously affect the production performance of chicks, and these Chemical drugs are difficult to metabolize, and also pose a potential threat...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K9/08A61P31/10A61P1/00
Inventor 田继业吴里明许冠英杜伟伟孙立云牛婵娟
Owner BAODING JIZHONG PHARMA
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