Composite material for manufacturing small-diameter artificial vascular grafts and manufacturing method for composite material

Abstract

The invention discloses a composite material for manufacturing small-diameter artificial vascular grafts and a manufacturing method for the composite material. The composite material is prepared from carboxyl bacterial cellulose and fibroin, wherein the fibroin and the carboxyl bacterial cellulose are compounded in a cross-linking manner through a cross-linking agent to form the composite material. According to the composite material disclosed by the invention, the carboxyl bacterial cellulose and the fibroin are compounded in the cross-linking manner through the cross-linking agent, so that the blood compatibility of the composite material is improved; the elasticity and the surface performance of the composite material are improved; the problems that the small-diameter artificial vascular grafts are relatively poor in blood compatibility and relatively high in plugging rate are solved; and a foundation is laid for research and application of the small-diameter artificial vascular grafts.

Description

technical field [0001] The present application relates to the field of artificial blood vessel materials, in particular to a composite material for the preparation of artificial small-diameter blood vessels and a preparation method thereof. Background technique [0002] Atherosclerotic vascular diseases, such as coronary artery disease and peripheral vascular disease, are seriously endangering human health. A large number of vascular grafts can effectively control such diseases, but small-diameter artificial blood vessel grafts are prone to problems such as restenosis caused by thrombus. In recent years, considerable progress has been made in the research of biomedical materials, which has also accelerated the development of artificial blood vessels, and more and more new materials have been applied to the research on the construction of artificial blood vessels. The existing various polymer materials used in clinical blood vessels can be divided into two categories, one is...

AI Technical Summary

Problems solved by technology

However, there are still many serious problems in replacing small-caliber blood vessels with a diameter of less than 6mm, such as extremity arteries and coronary arteries, including poor blood compatibility and high blockage rate.

Although natural polymer materials have more advantages than artificial synthetic materials, the small-caliber blood vessels made of natural polymer materials still have problems such as low strength, low elasticity, and poor compatibility.

Images