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Oral product for promoting gastrointestinal tracts to absorb astaxanthin and preparation method

A technology for gastrointestinal absorption and astaxanthin, applied in the field of bioengineering, can solve the problems of difficult to pass through biofilms, low oral bioavailability, etc., and achieve the effects of enhancing bioavailability, improving bioavailability, and simple operation.

Inactive Publication Date: 2015-11-18
HUBEI ASTA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For some drugs with high polarity, poor fat solubility and high molecular weight, their oral bioavailability is usually low because they are not easy to pass through biomembranes.

Method used

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  • Oral product for promoting gastrointestinal tracts to absorb astaxanthin and preparation method
  • Oral product for promoting gastrointestinal tracts to absorb astaxanthin and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment one (the following component weights are components in parts by weight)

[0040] 1. Preparation of soft capsules

[0041] (1), drug preparation

[0042] Take 120 parts of Haematococcus pluvialis oily extract and 6 parts of oryzanol, crush the solid material to 500-600 mesh, dissolve 6 parts of oryzanol in 120 parts of Haematococcus pluvialls oily extract to form a mixture Solution, weigh the solution weight, add safflower seed oil solution 500 times the weight of the mixed solution, stir in a water bath under normal pressure and heat to 40-60 ° C, keep warm at this temperature for 25-35 minutes, and then naturally cool to At room temperature of 25°C, make the oily medicated oil used in soft capsules for use;

[0043] (2), preparation of soft capsule shell:

[0044] Take gelatin, glycerin and water in a ratio of 1:0.4:1 by weight, and use the existing rubber preparation method to make soft rubber for use;

[0045] (3) Preparation of soft capsule products: ...

Embodiment 2

[0053] Embodiment two (the following component weights are components in parts by weight)

[0054] 1. Preparation of soft capsules

[0055] (1), drug preparation

[0056] Get 100 parts of Haematococcus Pluvialls oily extract and 5 parts of Pluvialls oil, crush the solid material to 500-600 mesh, dissolve 5 parts of Pluvialls oil into 100 parts of Haematococcus Pluvialls oily extract, Form a mixed solution, weigh the weight of the solution, add safflower seed oil solution 500 times the weight of the mixed solution, stir in a water bath under normal pressure and heat to 40-60 ° C, keep warm at this temperature for 25-35 minutes, and then naturally Cool to room temperature 25 ℃, make the used oily medicated oil of soft capsule stand-by;

[0057] (2), preparation of soft capsule shell:

[0058] Take gelatin, glycerin and water in a ratio of 1:0.4:1 by weight, and use the existing rubber preparation method to make soft rubber for use;

[0059] (3) Preparation of soft capsule pr...

Embodiment 3

[0067] Embodiment three (the following component weights are components in parts by weight)

[0068] 1. Preparation of soft capsules

[0069] (1), drug preparation

[0070] Take 80 parts of Haematococcus pluvialis oily extract and 20 parts of Chuanqiong extract, crush the solid material to 500-600 mesh, and dissolve 20 parts of Chuanqiong extract into 80 parts of Haematococcus pluvialls in oily state In the extract, a mixed solution is formed, weigh the solution weight, add safflower seed oil solution 500 times the weight of the mixed solution, stir with a water bath under normal pressure and heat to 40-60°C, and keep warm at this temperature for 25-35 Minutes, then naturally cool to room temperature 25 ℃, make the oily medicated oil used for soft capsules stand-by;

[0071] (2), preparation of soft capsule shell:

[0072] Take gelatin, glycerin and water in a ratio of 1:0.4:1 by weight, and use the existing rubber preparation method to make soft rubber for use;

[0073] (...

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Abstract

The invention provides an oral product for promoting gastrointestinal tracts to absorb astaxanthin and a preparation method. The oral product comprises the following components in parts by weight: 60-120 parts of algae source astaxanthin, 5-50 parts of absorption-assisting auxiliary materials, soft-capsule forming auxiliary materials, tablet forming auxiliary materials and oral liquid auxiliary materials, wherein the soft-capsule forming auxiliary materials comprise gelatin, glycerol and water at the ratio of 1 to 0.4 to 1. The preparation method of various oral products comprises the following steps: 1 preparing soft capsule products; 2 preparing tablets; 3 preparing hard capsules; and 4 preparing oral liquids. The product provided by the invention is capable of promoting absorption of the astaxanthin by gastrointestinal tracts, and improving the bioavailability of the astaxanthin. The safe and effective gastrointestinal tract absorption accelerants are blended under the condition that the existing raw material character conditions are not changed, so that the bioavailability of the astaxanthin is enhanced; and the operation is simple.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to an oral product and a preparation method for promoting the absorption of astaxanthin in the gastrointestinal tract. Background technique [0002] Astaxanthin, also known as "astaxanthin", a dark red substance, is the main carotenoid in aquatic animals in nature, and its chemical name is 3,3-dihydroxy-4,4-hydroxy-β-carotene , the molecular structure is as follows: [0003] [0004] Astaxanthin is a super antioxidant found in nature so far, and its antioxidant activity is 550-1000 times that of vitamin E. Previous animal experiments and human clinical trials have shown that astaxanthin has anti-oxidative / anti-inflammatory effects, can increase high-density lipoprotein, reduce triglycerides, reduce high-sensitivity C-reactive protein to prevent cardiovascular disease, and reduce tumor necrosis factor (TNF -α), as well as preventing diabetes, relieving diabetic complications, preve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/20A61K9/08A61K31/122A61K36/05A61K31/575A61K36/236A61K36/232A61K36/899A61K47/46A61K47/44A61K47/28A61K47/42A61K47/36A61K47/34A61K47/18
Inventor 张邦华杨远平李昌军
Owner HUBEI ASTA BIOTECH
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