Method for preparing polysaccharide-ADH derivative by means of A-group meningococcal refined sugar

A meningococcal,-ADH technology, applied in the field of preparation of polysaccharide-ADH derivatives, can solve the problems of unfavorable protection of human health and the environment, achieve better derivation effect, ensure human health, and increase the effect of ADH derivation rate
CN105056221AInactive Publication Date: 2015-11-18CHENGDU OLYMVAX BIOPHARM
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHENGDU OLYMVAX BIOPHARM
Publication Date
2015-11-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing a polysaccharide-ADH derivative by means of A-group meningococcal refined sugar. The method comprises the following steps that 1, meningococcal refined sugar and water for injection are mixed to be prepared into a polysaccharide solution, and pH is adjusted to be 9.0; 2, CDAP is dissolved into a CDAP solution through acetonitrile, the CDAP solution is added to the polysaccharide solution according to the weight proportion: polysaccharide:CDAP=1:0.4-0.6, stirring is carried out for 2-5 minutes at room temperature, and CDAP mixed liquid is prepared; 3, ADH is dissolved into an ADH solution with the concentration of 100 mg / ml through NaHCO3 with the concentration of 0.2 mol / L, the ADH solution is added to the CDAP mixed liquid according to the weight proportion: polysaccharide:ADH=1:3-5, and stirring is carried out for one hour at room temperature; 4, finally, filtering and freeze drying are carried out through an ultrafiltration membrane. The method has the advantages of being environmentally friendly, safe, good in derivation effect and the like.
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Description

technical field

[0001] The invention relates to a preparation method of polysaccharide-ADH derivatives, in particular to a method for preparing polysaccharide-ADH derivatives by using the refined sugar of group A meningococcus. Background technique

[0002] Meningococcal meningitis (referred to as meningitis, the same below) is an acute respiratory infectious disease caused by Neisseria meningitidis. For more than one hundred years, it has been popular or sporadic all over the world. It can cause sepsis and meningitis after infection with pathogenic bacteria. The susceptible population is mainly children, and the case fatality rate of fulminant type is the highest, which can reach 40% to 60%. The incidence rate in all continents of the world today is 1 / 100,000 to 10 / 100,000, and the total case fatality rate is 5% to 15%. Up to 20% of meningitis patients will have neurological sequelae, including intellectual impairment and deafness. Serological classification according to ...

Claims

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