Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-cancer drug nanocapsule with near-infrared photothermal response and preparation method thereof

An anti-cancer drug and near-infrared light technology, which is applied in the direction of drug combination, microcapsules, and capsule delivery, can solve problems such as no longer having near-infrared photothermal effect, failure of photothermal nano drug capsules, and stability of gold nanorods. , to achieve long-term stable photothermal conversion efficiency, ultra-high photothermal conversion efficiency, and high drug loading effect

Active Publication Date: 2015-11-25
BEIJING UNIV OF CHEM TECH
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a system still faces the problem of the stability of gold nanorods. After a period of illumination, gold nanorods are prone to structural changes, from nanorods to nanospheres, and its near-infrared photothermal effect is closely related to its shape. After being formed into nanospheres, it no longer has the near-infrared photothermal effect, resulting in the failure of photothermal nano drug capsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-cancer drug nanocapsule with near-infrared photothermal response and preparation method thereof
  • Anti-cancer drug nanocapsule with near-infrared photothermal response and preparation method thereof
  • Anti-cancer drug nanocapsule with near-infrared photothermal response and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] a.0.5mgCu 1.75 S nanosheets were dispersed in 5.0mL chloroform, 8uL allyl mercaptan (Alm) was added and stirred slowly at 30°C for 30 minutes; after that, acetone was added to the solution, centrifuged (10000r / min, 10min), and then chloroform and acetone The excess Alm was washed away, and this purification process was repeated 3 times to obtain Cu 1.75 S allyl thiol nanoparticles were then dispersed into 1.0 mL of chloroform;

[0020] b. 1.0mL contains 0.5mg of Cu 1.75 A chloroform dispersion of S allylthiol nanoparticles was mixed with 15 mL containing 300 mg N-isopropylacrylamide (NIPAM, monomer), 15 μg methacrylic acid (MAA, monomer) and 5 mg bisacrylamide (MBA, cross-linking agent). ) of sodium dodecylsulfonate (SDS) solution (sodium dodecylsulfonate concentration 1.0mg / mL), under vigorous stirring and ultrasound, a brown emulsion was obtained; chloroform was evaporated at 58°C for 20 minutes; then heated to 70°C, quickly add 1.0mL (10mg / mL) potassium persulfate...

Embodiment 2

[0024] a.0.5mgCu 1.75 S nanosheets were dispersed in 5.0mL chloroform, 8uL allyl mercaptan (Alm) was added and stirred slowly at 30°C for 30 minutes; after that, acetone was added to the solution, centrifuged (10000r / min, 10min), and then chloroform and acetone The excess Alm was washed away, and this purification process was repeated 3 times to obtain Cu 1.75 S allyl thiol nanoparticles were then dispersed into 1.0 mL of chloroform;

[0025] b. 1.0mL contains 0.5mg of Cu 1.75 Chloroform dispersion of S allylthiol nanoparticles was mixed with 15 mL containing 300 mg N-isopropylacrylamide (NIPAM, monomer), 15 μg methacrylic acid (MAA, monomer) and 10 mg bisacrylamide (MBA, crosslinker ) in sodium dodecylsulfonate (SDS) solution (1.0mg / mL), under vigorous stirring and ultrasonication, a brown emulsion was obtained; chloroform was evaporated at 58°C for 20 minutes; then heated to 70°C, and 1.0mL ( 10mg / mL) potassium persulfate (KPS, initiator) solution, maintain at 70°C for 5 ...

Embodiment 3

[0028] a.0.5mgCu 1.75 S nanosheets were dispersed in 5.0mL chloroform, 8uL allyl mercaptan (Alm) was added and stirred slowly at 30°C for 30 minutes; after that, acetone was added to the solution, centrifuged (10000r / min, 10min), and then chloroform and acetone The excess Alm was washed away, and this purification process was repeated 3 times to obtain Cu1.75 S allyl thiol nanoparticles were then dispersed into 1.0 mL of chloroform;

[0029] b. 1.0mL contains 0.5mg of Cu 1.75 Chloroform dispersion of S allylthiol nanoparticles was mixed with 15 mL containing 300 mg N-isopropylacrylamide (NIPAM, monomer), 15 μg methacrylic acid (MAA, monomer) and 15 mg bisacrylamide (MBA, crosslinker ) in sodium dodecylsulfonate (SDS) solution (1.0mg / mL), under vigorous stirring and ultrasonication, a brown emulsion was obtained; chloroform was evaporated at 58°C for 20 minutes; then heated to 70°C, and 1.0mL ( 10mg / mL) potassium persulfate (KPS, initiator) solution, maintain at 70°C for 5 ho...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an anti-cancer drug nanocapsule with near-infrared photothermal response and a preparation method thereof. The near-infrared photothermal characteristic of Cu1.75S NPs and the pH and temperature sensitivity of p(NIPAM-MAA) are combined, the surfaces of Cu2-xS nanoparticles with the near-infrared photothermal effect are covered with a layer of macromolecules sensitive to pH and temperature through in-situ polymerization, the thickness of the outer layer of macromolecules of the nanocapsule can be changed by adjusting the dosage of cross-linking agent bisacrylamide, then an anti-cancer drug is loaded, and leakage hardly occurs under normal physiological conditions (pH 7.4, 37 DEG C) without illumination. The nanocapsule has long-term stable ultrahigh photothermal conversion efficiency, high drug loading capacity (40%) and good biocompatibility. Furthermore, in-vitro and in-vivo photothermal chemotherapy results show that the nanocapsule can be used for long-distance non-destructive photothermal drug delivery and long-term continuous photothermal therapy and photothermal-controlled chemotherapy.

Description

technical field [0001] The invention belongs to the technical field of nano-medicine preparations, and in particular relates to a near-infrared photothermal response anticancer drug nanocapsule and a preparation method thereof. technical background [0002] Cancer treatment is faced with serious toxic and side effects problems, reducing toxic and side effects and improving treatment effects are the ultimate goals of basic cancer research and clinical treatment in medicine. The controlled release of anticancer drugs is an important means to solve this problem. Temperature, magnetic field, and light are few in vitro stimulating conditions that can be used to stimulate drug release and are relatively easy to control. Among them, temperature, as the most commonly used external stimulus for drug release, has been studied most extensively and deeply. Many drug capsules can release drugs in response to temperature, however, most of the related studies are limited to in vitro expe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K41/00A61K9/51A61K31/704A61K47/34A61P35/00
Inventor 汪乐余黄盛
Owner BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com