Preparation technology of modified microcrystalline cellulose

A technology for preparing microcrystalline cellulose and its preparation technology, which is applied in the field of preparation technology of modified microcrystalline cellulose, and can solve problems such as poor application effect and poor performance of microcrystalline cellulose composition

Active Publication Date: 2015-11-25
珠海市东辰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology simply mixes microcrystalline cellulose and sodium carboxymethyl cellulose, and the various performances of the microcrystalline cellulose composition obtained by it are poor, and the actual application effect is not good.

Method used

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  • Preparation technology of modified microcrystalline cellulose
  • Preparation technology of modified microcrystalline cellulose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The commercially available pulp (a pulp rich in α-cellulose made from fiber plants) was hydrolyzed in a hydrochloric acid solution at a temperature of 100°C and a pressure of 0.5Mpa for 60 minutes, filtered and washed to obtain microcrystals with a solid content of 45%. Cellulose filter cake. This filter cake is mixed into 6% 7LF sodium carboxymethyl cellulose, through fast paddle 62 revs / min, slow paddle 36 revs / min Z-shaped kneader (manufactured by Shandong Longxing Chemical Machinery Group, vacuum type kneader model NH -5) After kneading evenly, high-shear (FA30 type, prepared by FLUKO) 6 times (the outlet height of the first 2 times of shearing equipment is 12 mm, and the last 4 times of 24 mm), go to the high-pressure homogenizer, press Add pure water to the calculated solid content of the dry product at 20%, and after high-pressure homogenization for 30 minutes (pressure 20mpa), the product obtained by spray drying is used in traditional Chinese medicine preparati...

Embodiment 2

[0035] The filter cake of embodiment 1 is mixed into 8% 7LF sodium carboxymethyl cellulose, through fast paddle 40 revs / min, slow paddle 20 revs / min Z-shaped kneader (manufactured by Shandong Longxing Chemical Machinery Group, vacuum type kneader Model NH-5) After kneading evenly, high-shear (FA30 type, manufactured by FLUKO) 6 times (the outlet height of the first 2 times of shearing equipment is 12 mm, and the last 4 times of 24 mm), and turn to high-pressure homogeneous Machine, add pure water to the solid content of 28% according to the dry product, after high-pressure homogenization for 30 minutes (pressure 15mpa), the product obtained by air-flow drying is used in the food industry to improve the taste, thickening and stabilization of food. The relevant physical characterization parameters are shown in Table 1.

Embodiment 3

[0037] The filter cake high shear of embodiment 1 (FA30 type, is prepared by FLUKO) 4 times (the outlet height 10 millimeters of first 2 shearing equipment, 2 times 20 millimeters after the back), then mixed into 12% 7LF carboxymethyl Sodium cellulose, after kneading uniformly by a Z-shaped kneader (manufactured by Shandong Longxing Chemical Machinery Group, vacuum type kneader model NH-5) with a fast pulp of 50 rpm and a slow pulp of 30 rpm, it is transferred to a high-pressure homogeneous kneader. In a quality machine, 5% of the solid content is calculated as a dry product, and pure water is added, and after high-pressure homogenization for 120 minutes (pressure 20mpa), the product obtained by spray drying is used for suspension of intolerant drug suspensions. The relevant physical characterization parameters are shown in Table 1.

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Abstract

The invention discloses a preparation technology of modified microcrystalline cellulose, and relates to the field of medicinal chemistry. The preparation technology comprises the steps that a microcrystalline cellulose filter cake and 7LF sodium carboxymethylcellulose with the weight accounting for 5.5-9.3% of the weight of the microcrystalline cellulose filter cake are mixed and kneaded and are subjected to high-shear processing and high-pressure homogenization and dried; or after being subjected to high-shear processing, a microcrystalline cellulose filter cake and 7LF sodium carboxymethylcellulose with the weight accounting for 10-18.5% of the weight of the microcrystalline cellulose filter cake are mixed and kneaded and are subjected to high-pressure homogenization and dried. The obtained modified microcrystalline cellulose can be applied in a traditional Chinese medicine preparation for improving the traditional Chinese medicine loading capacity, applied in the food industry for improving food taste and achieving the thickening and stabilizing effects, and applied in indissolvable medicine suspension and dry suspension for achieving the suspension assisting effect.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a preparation process of modified microcrystalline cellulose. Background technique [0002] Microcrystalline cellulose (Microcrystalline cellulose, MCC) is a free-flowing extremely fine short rod-shaped or powder-like porous particle that is hydrolyzed by dilute acid to the limiting degree of polymerization (LOOP) of natural cellulose. It is white or nearly white in color and odorless. , odorless, the particle size is generally 20-80, and the limiting degree of polymerization (LODP) is 15-375; it is not fibrous and has strong fluidity. Insoluble in water, dilute acids, organic solvents and oils, partially soluble and swelling in dilute alkali solutions, and has high reactivity in the process of carboxymethylation, acetylation and esterification. Due to its special properties such as low degree of polymerization and large specific surface area, microcrystalline cellulose is wid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/04C08L1/28A61K47/38
Inventor 段民英刘武先
Owner 珠海市东辰制药有限公司
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