Method for determining content of drug components in mixture drug

A technology of mixing drugs and mass percentage content, which is applied in the field of terahertz time-domain spectroscopy detection, can solve the problems of high professional technical requirements, low detection limit, expensive instruments, etc., and achieve the goals of avoiding harmful ionization, multiple data and accuracy Effect

Active Publication Date: 2015-11-25
CHINA JILIANG UNIV
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  • Application Information

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Problems solved by technology

Chromatographic methods generally have the disadvantages of sample preparation, derivative analysis, high technical requirements, and expensive instruments, but surface-enhanced Raman spectroscopy needs to enhance the substrate material, which may interact with pyrazinamide, and pyrazinamide in the near-infrared band Weak vibration absorption, low detection limit

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  • Method for determining content of drug components in mixture drug
  • Method for determining content of drug components in mixture drug
  • Method for determining content of drug components in mixture drug

Examples

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Effect test

Embodiment 1

[0085] (1) Establish a test model and detect the content of each drug component in the mixed drug sample to be tested

[0086] In this embodiment, the mixed drug is a mixture of pyrazinamide and isoniazid.

[0087] A mathematical method is used to establish a test model for the corresponding relationship between the content of pyrazinamide in the mixed medicine and the effective optical parameters of the mixed medicine. The specific method is as follows:

[0088] a. Preparation of standard samples

[0089] Weighed 16 groups of pure pyrazinamide and pure isoniazid with different masses respectively, and prepared 16 standards. The mass percentages of pyrazinamide in each standard are different, being 0%, 2.00%, 5.00%, 8.94%, 15.30%, 19.94%, 25.00%, 29.88%, 40.99%, 50.11%, 70.10% %, 74.97%, 80.03%, 85.00%, 88.98%, 100%. Wherein, the mass percentage composition of pyrazinamide is 100% standard substance shows that the component in this standard substance is pure pyrazinamide a...

Embodiment 2

[0138] In this embodiment, the mixed medicine is formed by mixing pyrazinamide and isoniazid.

[0139] The method for measuring the content of pyrazinamide in the mixed medicine of the present embodiment is different from Example 1 as follows:

[0140] (i) The established test model is the corresponding relationship between the mass percentage content of pyrazinamide in the mixed drug and the effective refractive index of the mixed drug.

[0141] (ii) Refractive index formula: n ( ω ) = φ ( ω ) ω d + 1

[0142] In the above formula, φ(ω) is the phase difference between the signal of the measured sample (that is, the terahertz time-domain spectrum obtained by scanning the measured sample) and its reference signal (the terahertz time-domai...

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Abstract

The invention discloses a method for determining the content of drug components in a mixture drug. The mixture drug is prepared from a first drug and a second drug. The preparation method comprises the following steps: (1) preparing a group of standard samples with different component contents; (2) collecting the terahertz time-domain spectrums of each standard sample and air, and respectively converting the terahertz time-domain spectrums into absorption coefficients and refractive indexes of corresponding frequency domain; (3) determining the terahertz band confidence interval of a test model; (4) selecting a group of optical parameters in the terahertz band confidence interval of each standard sample in the test model to be used as effective optical parameters and establishing a corresponding effective optical parameter matrix; (5) establishing a test model of the corresponding relationship between the content of the first drug and the effective optical parameters of each standard sample; and (6) inputting the effective optical parameter matrix of the sample of the to-be-tested mixture drug to the test model to obtain the content of the first drug in the to-be-tested mixture drug. By utilizing the method, the content of the drug components in the mixture drug can be quickly detected in a lossless way.

Description

technical field [0001] The invention relates to a method for measuring the content of drug components in mixed drugs, and belongs to the technical field of terahertz time-domain spectral detection. Background technique [0002] Combination medication refers to the method of applying two or more drugs simultaneously or sequentially in order to achieve the purpose of treatment. It has been widely used in clinical treatment. While improving the curative effect, the combined drug can avoid drug resistance caused by a certain drug when it is used alone. When combined drugs are used, combined drugs with different content ratios can be selected according to the different conditions of the patients. [0003] In the following, pyrazinamide and isoniazid are taken as examples for illustration. Pyrazinamide and isoniazid are widely used clinically as first-line oral anti-tuberculosis drugs, and they can be used alone or in combination. In recent years, counterfeit and shoddy drugs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3586G01N21/41
Inventor 张琪方虹霞杜勇洪治刘建军
Owner CHINA JILIANG UNIV
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