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Novel ion source and ionization method

An ion source and ionization technology, applied in the field of ion sources, can solve problems such as inappropriate miniaturization of instruments, complex design, and poor reliability of devices, so as to facilitate miniaturization and integration, improve efficiency and stability, and improve device reliability sexual effect

Active Publication Date: 2015-11-25
CHINA INNOVATION INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For these ion sources, the sample must undergo cumbersome pretreatment before ionization. Therefore, the common deficiency of these ion sources is that the sample cannot be directly and quickly desorbed and ionized, that is, the continuous and real-time monitoring of the target components cannot be achieved. Throughput analysis or imaging analysis
[0005] DESI ion source requires a high-voltage power supply to build a high-voltage electrostatic field, which makes corona prone to occur at the front of the electrospray capillary. High voltage also limits the possibility of developing a handheld ion source and directly performing non-destructive and rapid analysis on the surface of human skin; the ions used Solvent and high flow rate of gas, not only high cost but also will cause some pollution to the environment
[0006] The DART ion source eliminates the solvent, but it still needs high voltage and high flow rate ionized gas, and in order to obtain stable and efficient ionization effect, it is necessary to use electrodes, but multi-electrode (high voltage electrode, grid electrode, ground electrode) ) is complex in design, and it is not suitable to realize the miniaturization of the instrument
[0007] DBDI ion source, in the DBDI with dual electrodes inside the ion source, the internal electrodes, especially the rod-shaped and needle-shaped electrodes, are very easy to oxidize and fail under high temperature and high air flow conditions, resulting in poor reliability of the device, and full consideration must be given to maintainability, resulting in The overall design is complex
However, DBDI with two electrodes inside and outside the ion source is not suitable for sample surface ionization. It is usually suitable for liquid samples and regular thin-layer solid samples, and is not suitable for samples where the external ground electrode is difficult to place, such as irregular or thick samples. Large samples, etc., which limit the scope of application of on-site, real-time analysis

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0042] figure 1 Schematically provides a cross-sectional view of the novel ion source of the embodiment of the present invention, as figure 1 As shown, the novel ion source includes:

[0043] The first insulation tube 11, the two ends of the first insulation tube are open; the first insulation uses insulating media such as glass and ceramics;

[0044] There is only one electrode 21, which is arranged on the outside of the first insulating tube, and the electrode has a terminal;

[0045] The second insulating tube 31 is arranged on the outside of the first insulating tube and on the radial side of the electrode that is not the first insulating tube. The open end of the first insulating tube away from the second insulating tube has an inner diameter constricted section 12, and the inner diameter constricted section is located at the side of the electrode.

[0046] The ionization method of the embodiment of the present invention, that is, the working process of the above-menti...

Embodiment 2

[0053] figure 2 Schematically provides a cross-sectional view of the novel ion source of the embodiment of the present invention, as figure 2 As shown, the novel ion source includes:

[0054] The first insulating tube, the two ends of the first insulating tube are open; the first insulating tube includes a first part 18 and a second part 19, and one end of the first part 18 is sleeved on one end of the second part 19; The second part is made of ceramic material as a heating element to heat the passing carrier gas;

[0055]There is only one electrode 21, which is arranged on the outside of (the first part of) the first insulating tube, and the electrode has a terminal;

[0056] The second insulating tube 31, the second insulating tube is arranged on the outside of the first insulating tube and is on the radial side of the electrode that is not the first insulating tube; the second insulating tube and the second insulating tube There is a cavity 51 between them, filled with...

Embodiment 3

[0068] An application example of the novel ion source and ionization method according to Embodiment 2 of the present invention in the detection of caffeine.

[0069] In this application example, the first part of the first insulating tube is made of glass, and the second part is made of ceramics; the second insulating tube is made of ceramics; the AC power applied to the electrodes is 7W, the maximum voltage is 5kV, and the frequency is 50Hz; the temperature measuring element adopts A thermocouple, mounted on said second part, with its tip 5 cm from the electrodes. To build a combined analysis platform of DBDI ion source and mass spectrometry, take 100uL of caffeine standard sample (concentration 100ppb) dissolved in methanol and place it in the sample area of ​​the ion source. Helium is used as the carrier gas with a flow rate of 1.2L / min. The air temperature is 250°C. The hydrogenation ion peak [M+H]+ of caffeine is obtained in the mass spectrometry results, and the m / z val...

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Abstract

The invention provides a novel ion source and an ionization method. The novel ion source comprises a first insulating pipe, an electrode and a second insulating pipe, wherein openings are formed in two ends of the first insulating pipe; only one electrode is arranged at the outer side of the first insulating pipe; the electrode comprises a wiring end; and the second insulating pipe is arranged at the outer side of the first insulating pipe and is located at the non-radial side part of the first insulating pipe of the electrode. The novel ion source has the advantages of wide application range and the like.

Description

technical field [0001] The invention relates to an ion source, in particular to an ion source and an ionization method. Background technique [0002] Mass spectrometry is one of the most sensitive and broadly applicable analytical methods known today. In mass spectrometry, the ion source is the key device for sample ionization. [0003] At present, there are many kinds of ion sources, such as electron bombardment ion source (EI), chemical ionization source (CI), field ionization / field desorption ionization source (FI / FD), fast atom bombardment source (FAB), electrospray ionization Source (ESI), Laser Desorption Source (LD), Atmospheric Pressure Chemical Ionization Source (APCI), etc. For these ion sources, the sample must undergo cumbersome pretreatment before ionization. Therefore, the common deficiency of these ion sources is that the sample cannot be directly and quickly desorbed and ionized, that is, the continuous and real-time monitoring of the target components cann...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/10
Inventor 赵鹏闻路红
Owner CHINA INNOVATION INSTR CO LTD