Method for detecting full ingredient granule Chinese herbal roasted myrrh based on terahertz spectrum technology

[0029] Example 1

[0030] This embodiment provides a method for detecting Myrrha serrata using terahertz time-domain spectroscopy, which includes the following steps:

[0031] 1) Sample preparation: The sample used is the all-component Chinese medicated myrrh granules produced by Beijing Kangrentang Pharmaceutical Co., Ltd., weigh about 60 mg of myrrh granules with an electronic balance, and then grind them into a fine powder in a mortar The shape is then shaped in a tablet press, the pressure is increased to 5 tons, and the time is 8 minutes, so that a disc with a diameter of 13 mm will be obtained with smooth sides and a thickness of less than 0.4 mm.

[0032] 2) Sample test: After turning on the laser until the output power is stable, calibrate the light collimation in the optical path; turn on the laptop, set the measurement parameters on the terahertz spectroscopy system software program panel, and perform the measurement after the laser is warmed up for one hour; Put the prepared empty sample rack into the sample chamber position in the light path; then start filling with nitrogen until the humidity in the chamber drops below 1%, and collect the terahertz transmission time domain spectrum of the empty sample rack; take the terahertz time domain of the empty sample rack The domain waveform is the reference signal. Next, put the compressed tablets in the empty sample rack and put them in the position of the sample compartment, flush with nitrogen, and repeat the above method to obtain the terahertz transmission time-domain spectrum data of the traditional Chinese medicine sample, based on this terahertz time-domain waveform As a sample signal. In order to improve the accuracy and precision, the measurement is repeated at least three times for each sample, and the average value is taken as the final reference signal and sample signal.

[0033] 3) Data processing: Signal processing: Fast Fourier transform the time-domain waveforms of the reference signal and the sample signal, and then use the data processing model based on the Fresnel principle to calculate the effective terahertz band of Chinese medicinal myrrh The absorption coefficient α(v):

[0034] κ=(c/2πdv)ln(4n/(A(1+n) 2 ))=αc/4πv

[0035] Among them, φ is the phase difference between the sample electric field (the electric field of the tablet sample) and the reference electric field (the electric field of the empty sample holder), d is the sample thickness, v is the frequency of radiation, and c is the speed of light in vacuum.

[0036] Among them, the effective terahertz band frequency range can be calculated using multiple sets of data including time and amplitude intensity obtained after the terahertz time domain system is used to scan and detect the sample.

[0037] 4) Spectral analysis: From the broad absorption spectra of Zhimyia granules ( figure 2 ) It can be seen that because it can be in a wide frequency range greater than 3THz, it can obtain more effective absorption peak positions than the conventional terahertz time-domain spectroscopy system. These absorption peaks originate from intermolecular or intramolecular internal medicine. Various interaction forces.