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Medicinal uses of Morusin

A technology for morinol and medicine, which is applied to the use of garcinthone compounds and related product fields, and can solve problems such as liver function damage and allergic rash.

Active Publication Date: 2018-02-13
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is often accompanied by severe side effects such as fever, allergic rash, abdominal pain, diarrhea, leukocyte and thrombocytopenia, and liver function damage.

Method used

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  • Medicinal uses of Morusin
  • Medicinal uses of Morusin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The separation of embodiment 1 compound Morusin

[0034] Experimental Materials

[0035] The papaya branch was collected in Yunnan Province, China in 2010, and the medicinal material specimen (No. 20100801) is now stored in the Shanghai University Engineering Research Center for Innovative Drug Research and Development of Traditional Chinese Medicine. Petroleum ether, ethanol and other reagents are analytical grade reagents, purchased from Sinopharm Chemical Reagent Co., Ltd.; silica gel powder was purchased from Qingdao Ocean Chemical Factory Branch, China; TLC thin-layer chromatography silica gel plate was purchased from Yantai Jiangyou Silica Gel Development Co., Ltd. ; Sephadex LH-20 (GE Healthcare Bio-Sciences AB, Sweden).

[0036] Bruker AV-400 nuclear magnetic spectrometer (TMS reference material); Agilent 1100 series MSD ion trap mass spectrometer, Agilent 6210ESI-TOF and Agilent 6520ESI-Q-TOF. High performance liquid chromatography (Waters, model 2695).

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PUM

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Abstract

The invention relates to the field of medicine and health products, in particular to a medical application of ariferin and its product. The Morusin of the invention can be used to prepare medicines for preventing and treating hyperuricemia or gout.

Description

technical field [0001] The invention relates to the field of medicine, food and health care products, in particular to the use of a garcinoid compound and related products. Background technique [0002] Gout is a group of clinical syndromes caused by the disorder of purine metabolism in the body or the decrease of uric acid excretion, which leads to the deposition of uric acid in joints and other places in the body. Sustained high blood uric acid value is a necessary but not sufficient condition for triggering gout. According to statistics, 5%-12% of patients with hyperuricemia will develop gout, but hyperuricemia can also exist alone for a long time without developing gout. [0003] Xanthine oxidase (Xanthine Oxidase, XOD) is an important enzyme in the process of purine metabolism in the body, which can catalyze the oxidation of xanthine and hypoxanthine to uric acid and generate superoxide radicals at the same time. As mentioned earlier, excessive uric acid concentration ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P19/06
Inventor 徐宏喜祝伦伦邵以诺付文卫张洪谭红胜
Owner SHANGHAI UNIV OF T C M