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A kind of degradable vascular stent and its preparation method and application

A vascular stent and tube wall technology, applied in the field of degradable vascular stent materials and their preparation, and vascular stent materials, can solve problems such as technical difficulties, and achieve broad market prospects, good mechanical strength, and good blood flow.

Active Publication Date: 2017-11-21
青岛健康海洋生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of solubility, it has technical difficulties in practical application

Method used

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  • A kind of degradable vascular stent and its preparation method and application
  • A kind of degradable vascular stent and its preparation method and application
  • A kind of degradable vascular stent and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A degradable vascular stent, characterized in that it is a hollow tubular structure made of acylated amino polysaccharide, the inner surface of the tubular structure has an anticoagulant coating, the outer surface of the tubular structure has a developing coating, and the tube wall has or There is no transparent pore structure or pattern structure.

[0038] The acylated amino polysaccharide is a polyacylated glucosamine polysaccharide, the total degree of acylation in its molecular structure is greater than or equal to 70%, and the acyl group is acetyl, propionyl, butyryl, hexanoyl, octanoyl, One or more of caproyl, lauroyl, palmitoyl and other aliphatic or aromatic acyl groups, the molecular structure formula of acylated amino polysaccharide is:

[0039]

[0040] In the formula, R 1 , R 2 or R 3 is H, acetyl (-C 2 h 3 O), propionyl (-C 3 h 5 O), butyryl (-C 4 h 7 O), caproyl (-C 6 h 11 O), octanoyl (-C 8 h 15 O) or one or more of caproyl, lauroyl, palmi...

Embodiment 2

[0045] Example 2 Screening of degradable vascular stent base materials:

[0046] (1) Preparation of diaphragm:

[0047] The preparation of chitosan diaphragm: take chitosan powder (deacetylation degree 92.5%) 2g, add 2% acetic acid aqueous solution (volume fraction) 100ml, stir and dissolve, be mixed with weight volume ratio (w / v) be 2 % chitosan glue. Measure 15ml of chitosan glue respectively, place them in a PP square plate with a side length of 50mm×50mm, and let it dry in a fume hood. The dried membrane is placed in 2% NaOH aqueous solution (weight percent concentration, the same below) for acid-base neutralization, washed with water until the pH is neutral, and dried to obtain a chitosan membrane.

[0048] Preparation of chitin film: Weigh 2 g of chitin powder, add 100 ml of hexafluoroisopropanol solution, stir to dissolve, and prepare 2% chitin glue (w / v). Measure 15ml of chitin glue respectively, place them in a stainless steel square plate with a side length of 50m...

Embodiment 3

[0057] Example 3 Preparation of degradable vascular stent tubing 1:

[0058] Weigh 20g of chitosan powder (deacetylation degree 92%), put it into a glass reaction vessel, add 50mL of acylating reagent acetic anhydride solution, add 100ml of methanol, control the temperature at 10°C, add 70% perchloric acid solution under stirring 1ml was used as a catalyst, and the reaction was stirred for 36h. After the reaction is complete, filter, separate the solid from the liquid, put the solid into 5% NaOH aqueous solution, neutralize the acid and alkali, centrifuge, separate the solid from the liquid, elute the salt from the solid with water, dehydrate with 95% ethanol, heat and dry at 60°C to obtain acylation Acylated amino polysaccharide 1 with a degree of 74.5%. Acylated amino polysaccharide 1 has an acetyl structure with an acetyl content of 74.5%.

[0059] Take by weighing 2.5g of the above-mentioned acylated amino polysaccharide 1, add 61ml of hexafluoroisopropanol solution (spe...

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Abstract

The invention discloses a degradable blood vessel stent. The degradable blood vessel stent is characterized in that the degradable blood vessel stent is of a hollow tubular structure made of acyl amino polysaccharide, the inner surface of the tubular structure is provided with an anticoagulation coating, the outer surface of the tubular structure is provided with a development coating, and the tube wall is provided with or not provided with a transparent hole structure or pattern structure. The degradable blood vessel stent can be applied to treatment of narrowing or embolism of vascular lumen and can be degraded and absorbed in a human body.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a vascular stent material, in particular to a degradable vascular stent material and its preparation method and application. Background technique [0002] Vascular stents are implantable medical device products used for the treatment of vascular lumen stenosis or embolization caused by vascular diseases, to "stretch" the narrowed blood vessels, increase blood flow and prevent myocardial infarction. The vascular stents currently used clinically are mainly metal vascular stents. Metal vascular stents can meet the supporting effect on the vascular lumen when applied to blood vessels, but metal materials cannot be degraded. % restenosis, but also biocompatibility problems such as endothelial dysfunction, chronic inflammation, and mismatch of mechanical properties between blood vessels and stents. Since the non-degradable metal stent material cannot be taken out, it brings obstacles...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/10A61L31/16A61L33/08
Inventor 刘万顺
Owner 青岛健康海洋生物制药有限公司
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