Novel print recognition based metronidazole electrochemical sensor, preparation method and application

A metronidazole and electrochemical technology, which is applied in the field of clinical analysis and food safety monitoring, can solve the problems of reducing the selectivity of conductive MIP sensors, etc., and achieve the effects of enhanced imprint recognition ability, wide applicability, and direct and efficient signal conversion
CN105181780AInactive Publication Date: 2015-12-23NANHUA UNIV
3 Cites 6 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
NANHUA UNIV
Publication Date
2015-12-23
Estimated Expiration
Not applicable ยท inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a novel print recognition based metronidazole electrochemical sensor, a preparation method and an application. The preparation method of the sensor comprises following steps: graphite powder and paraffin oil are uniformly mixed to form carbon paste, a carbon paste electrode is prepared and put in a sulfuric acid solution for potential scan round, and a conductive film carbon paste electrode is prepared; sol proportionally prepared from APTMS (aminopropyl trimethoxysilane), TEOS (tetraethoxysilane), 2-ethoxyethanol, a metronidazole containing 2-ethoxyethanol solution, an NaOH solution and deionized water is dispensed on the surface of the conductive film carbon paste electrode dropwise, a heterogeneous double-layered-based molecularly imprinted polymer film modified carbon paste electrode is obtained and connected with an electrochemical device, and the sensor is assembled. The sensor has enhanced print recognition capacity and wide applicability, has the characteristics of high sensitivity, good selectivity, wide linear range, high precision and accuracy, low detection cost, environment-friendliness, portability, suitability for field monitoring and the like, further, the preparation process is simple, the cost is low, and the service life is long.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of clinical analysis and food safety monitoring, and particularly relates to a metronidazole electrochemical sensor based on a novel imprint recognition, that is, a double-layer heterogeneous molecularly imprinted polymer, a preparation method and its application in medicine, clinical, food and related products ( Such as feed, etc.) in the application of nitroimidazole drug analysis and monitoring. Background technique

[0002] Metronidazole belongs to 5-nitroimidazole drugs (wherein the English name and structure see figure 1 ), has antibacterial and antiprotozoal activity, and is often used in the treatment of human trichomoniasis, piriformis, amebic liver abscess and other diseases. Studies have shown that excessive use or abuse of metronidazole will cause it to accumulate in the human body, and when it reaches or exceeds a certain amount, it will induce epilepsy, peripheral neuropathy and disorders and other dise...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More