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Method for preparing nano particles for adsorption of heavy metal ions

A technology of nano-particles and heavy metals, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of unseen preparations, and achieve simple preparation methods, good effects, and stability Good results

Active Publication Date: 2016-01-13
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no APS (artificialPulmonarySurfactant) has been used in the preparation of heavy metal ion adsorption materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] a. In the ethanol that is 2000 parts by mass, add 20 parts of dipalmitoylphosphatidylcholine, 10 parts of cholesterol, and 30 parts of phospholipids;

[0022] b. Stir magnetically at 40°C for 30 minutes until completely dissolved and no obvious lumps;

[0023] c. in the water of 2000 parts by mass, add 20 parts of acetic acid, after mixing, add 100 parts of chitosan;

[0024] d. Stir magnetically at room temperature for 12 hours until completely dissolved and no obvious particles;

[0025] e. Add the solution obtained in b to the solution obtained in d, and keep stirring at 50° C. for 60 minutes to obtain chitosan nanoparticles.

[0026] Test result: Particle size analysis is carried out after dilution, and the particle size is mainly distributed at 388nm.

Embodiment 2

[0028] a. In the ethanol that is 2000 parts by mass, add 40 parts of dipalmitoylphosphatidylcholine, 10 parts of cholesterol, and 50 parts of phospholipids;

[0029] b. Stir magnetically at 50°C for 30 minutes until completely dissolved and no obvious lumps;

[0030] c. in the water of 2000 parts by mass, add 20 parts of acetic acid, after mixing, add 100 parts of chitosan;

[0031] d. Stir magnetically at room temperature for 12 hours until completely dissolved and no obvious particles;

[0032] e. Add the solution obtained in b to the solution obtained in d, and keep stirring at 70° C. for 60 minutes to obtain chitosan nanoparticles.

[0033] Test result: Particle size analysis after dilution, the particle size is mainly distributed at 293nm.

Embodiment 3

[0035] a. In the ethanol that is 2000 parts by mass, add 80 parts of dipalmitoylphosphatidylcholine, 100 parts of cholesterol, and 10 parts of phospholipids;

[0036] b. Stir magnetically at 70°C for 50 minutes until completely dissolved and no obvious lumps;

[0037] c. in the water of 2000 parts by mass, add 40 parts of acetic acid, after mixing, add 80 parts of chitosan;

[0038] d. Stir magnetically at room temperature for 18 hours until completely dissolved and no obvious particles;

[0039] e. Add the solution obtained in b to the solution obtained in d, and keep stirring at 50° C. for 120 minutes to obtain chitosan nanoparticles.

[0040] Test result: Particle size analysis after dilution, the particle size is mainly distributed at 350nm.

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Abstract

The invention provides a method for preparing nano particles for adsorption of heavy metal ions. The method includes steps: (1) adding a certain amount of acetic acid into water, stirring to obtain an acetic acid solution in a certain concentration, weighing a certain amount of chitosan powder to add into the acetic acid solution, and stirring for a certain time to obtain a well dissolved chitosan-acetic acid solution; (2) weighing a certain amount of dipalmitoyl phosphatidyl choline, cholesterol and phospholipid, adding an appropriate amount of ethyl alcohol and stirring to obtain a completely dissolved solution; (3) adding the dipalmitoyl phosphatidyl choline-ethyl alcohol solution into the chitosan-acetic acid solution, and constantly stirring at a certain temperature to obtain chitosan nano particles. The nano particles for adsorption of the heavy metal ions have the advantages of high efficiency, low cost, adsorption of a great variety of ions and the like.

Description

technical field [0001] The invention relates to the field of preparation of nanometer materials, in particular to a method for preparing nanoparticle for adsorbing heavy metal ions. Background technique [0002] Chitosan is a cationic polymer, insoluble in common organic solvents, stable in lye, has strong hydrophilicity, can expand and form gel in dilute hydrochloric acid and dilute acetic acid solutions, and can be made into various A slow-release, controlled-release dosage form (Miyazaki et al., 1988; Sawayanagi et al., 1982) has good film-forming properties, and the chitosan film after water swelling is a tough elastic material; because chitin has a strong crystalline structure, it dissolves Chitosan, as a drug carrier, can control the drug release, prolong the curative effect of the drug, reduce the side effects of the drug, improve the permeability of the hydrophobic drug to the cell membrane and the stability of the drug, and change the route of administration. The t...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/722A61K47/24A61K47/28A61P39/02A61K31/685
Inventor 何丹农朱君易帆乔宇姚燕杰刘恬
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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