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Bakuchiol extractive, and preparation method and application thereof

A technology of bakuchiol and its extract, which is applied in the field of bakuchiol extract and its preparation, can solve the problems of low bakuchiol purity, large solvent consumption, and high instrument cost, and achieve simple and feasible operation and easy preparation Simple method and good repeatability

Inactive Publication Date: 2016-01-13
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How to quickly extract and separate a large amount of bakuchiol is a problem of close attention in industrial production. At present, the methods for extracting and separating bakuchiol include macroporous resin method and high performance liquid chromatography. The purity of bakuchiol obtained by the former is relatively high. Low, the bakuchiol isolated by the latter has high purity, but the high cost of instruments and large solvent consumption limit the application of this technology

Method used

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  • Bakuchiol extractive, and preparation method and application thereof
  • Bakuchiol extractive, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation method of bakuchiol extract and bakuchiol, concrete steps are as follows:

[0036] (1) Weigh 1.003kg of psoralen medicinal material, pulverize it, put it in a plastic bucket, add 5L of petroleum ether and shake it up, then extract by cold soaking for 36 hours, extract 3 times, combine the extracts, recover the solvent, and obtain the bakuchiol extract 140g, the yield is 14.0%;

[0037] (2) Add 70 mL of petroleum ether to the above-mentioned bakuchiol extract to dissolve, add 168 g of silica gel (200-300 mesh) to mix the sample, grind in a fume hood and let the solvent evaporate naturally to become loose;

[0038] (3) Mix 850mL of petroleum ether and 168g of silica gel (100-200 mesh), stir to remove air bubbles, slowly pour into the silica gel column after soaking completely, then continue to add petroleum ether, wash the silica gel attached to the tube wall Next, make the silica gel on the surface of the glass column smooth;

[0039] (4) Slowly add the...

Embodiment 2

[0041] The preparation method of bakuchiol extract and bakuchiol, concrete steps are as follows:

[0042] (1) Weigh 1.002kg of psoralen medicinal material, pulverize it, put it in a plastic bucket, add 10L of petroleum ether and shake it up, and then extract by cold soaking for 24h, extract twice, combine the extracts, recover the solvent, and obtain the bakuchiol extract 134g, the yield is 13.4%;

[0043] (2) After the above bakuchiol extract was dissolved in 67 mL of petroleum ether, add 161 g of silica gel (200-300 mesh) to mix the sample, grind it in a fume hood and let the solvent evaporate naturally to become loose;

[0044] (3) Mix 800mL of petroleum ether and 161g of silica gel (100-200 mesh), stir to remove air bubbles, slowly pour into the silica gel column after soaking completely, then continue to add petroleum ether, wash the silica gel attached to the tube wall Next, make the silica gel on the surface of the silica gel column smooth;

[0045] (4) Slowly add the...

Embodiment 3

[0047] The preparation method of bakuchiol extract and bakuchiol, concrete steps are as follows:

[0048] (1) Weigh 1.004kg of psoralen medicinal material, pulverize it, put it in a plastic bucket, add 15L of petroleum ether and shake it up, then extract by cold soaking for 12 hours, extract once, combine the extracts, recover the solvent, and obtain the bakuchiol extract 118g, the yield is 11.8%;

[0049] (2) After adding 60 mL of petroleum ether to the above-mentioned bakuchiol extract to dissolve, add 142 g of silica gel (200-300 mesh) to mix the sample, grind it in a fume hood and allow the solvent to evaporate naturally to become loose;

[0050](3) Mix 710mL of petroleum ether and 142g of silica gel (100-200 mesh), stir to remove air bubbles, slowly pour into the silica gel column after soaking completely, then continue to add petroleum ether, wash the silica gel attached to the tube wall Next, make the silica gel on the surface of the silica gel column smooth;

[0051]...

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Abstract

The invention relates to a bakuchiol extractive, and a preparation method and application thereof. The preparation method comprises crushing psoralea corylifolia medicinal material, performing cold-dipping extraction by using petroleum ether, and recovering the solvent, so as to obtain the bakuchiol extractive; adding petroleum ether for dissolving, blending the sample with silica gel to obtain a loose mixture, completely volatizing the solvent, applying the sample to a silica gel column for column chromatography, eluting by using petroleum ether, performing TLC tracking, merging eluates containing bakuchiol, and recovering the solvent, so as to obtain a bakuchiol crude product; and further purifying the bakuchiol crude product, concretely, dissolving the crude product with petroleum ether, blending the sample with silica gel to obtain a loose mixture, completely volatilizing the solvent, applying the sample to a silica gel column for column chromatography, eluting by using petroleum ether and ethyl acetate, performing TLC tracking, merging eluates containing bakuchiol, and recovering the solvent, so as to obtain a bakuchiol purified product. The technology is simple to operate, low in cost and stable in yield, is capable of rapidly obtaining bakuchiol a in large scale, and is suitable for large-scale industrialized production demands.

Description

technical field [0001] The invention relates to the technical field of extraction and separation of traditional Chinese medicine psoraleae, in particular to bakuchiol extract and its preparation method and application. Background technique [0002] Psoralen is the dried and mature fruit of Psoralea corylifolia L., a leguminous plant. It was first seen in "Kaibao Materia Medica". It is distributed in Shanxi, Shaanxi, Anhui and other places. effect. Modern studies have shown that psoralen mainly contains glycosides, coumarins, flavonoids, and monoterpene phenols. Bakuchiol is an important active ingredient in psoralen. Bakuchiol has various pharmacological activities such as lowering blood sugar and blood fat, anti-inflammatory and antibacterial, anti-oxidation, protecting liver cells, anti-cancer, and phytoestrogens-like effects. Bakuchiol has great development value in anti-acne cosmetics, mouthwash and so on. How to quickly extract and separate a large amount of bakuchio...

Claims

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Application Information

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IPC IPC(8): C07C39/19C07C37/70
CPCC07C39/19C07C37/685C07C37/70
Inventor 王跃飞高秀梅张波泳朱彦江振作柴欣
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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