A kind of imidazole curing agent and preparation method thereof
A technology of imidazoles and curing agent, applied in the field of imidazoles curing agent and preparation thereof, can solve problems such as short storage time, and achieve the effects of easy popularization and simple and feasible preparation method
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0034] Embodiment 1: the preparation of 7-methylcoumarin
[0035] Mix m-cresol (20ml, 0.19mol) with malic acid (25.4g, 0.19mol), add 98% mass fraction of concentrated sulfuric acid (20.9g) dropwise under an ice-water bath, stir at room temperature for 0.5h after addition, and then heat up to 120 ℃ for 3h until no gas escapes. Cool, pour into ice-water mixture, extract with 250ml ethyl acetate several times, combine organic layers, wash with water, anhydrous NaSO at room temperature 4 After drying for 18 hours, the solvent was distilled off at 80°C and recrystallized from 95% ethanol to obtain white needle-like crystals (12.5 g, yield 43%) with a melting point of 125-128°C.
Embodiment 2
[0036] Embodiment 2: the preparation of 7-bromomethyl coumarin
[0037] Mix 7-methylcoumarin 1b (1g, 6.25mmol), NBS (1g, 5.62mmol), benzoyl peroxide (0.01g), and dry benzene 20ml, reflux at 80°C for 6h, and evaporate to dryness at 80°C solvent, washed with hot water, and recrystallized from glacial acetic acid to obtain white needle-like crystals (0.6 g, yield 40%) with a melting point of 178-180°C.
Embodiment 3
[0038] Embodiment 3: the preparation of 1-(coumarin-7-methylene) imidazole
[0039] Imidazole (0.16g, 2.32mmol), NaH (0.18g, 7.5mmol), DMF10ml, stirred at room temperature, added 7-bromomethylcoumarin (0.5g, 2.10mol), heated to 70°C, reacted for 2h, cooled, Pour into water, extract with 50ml ethyl acetate, wash with saturated sodium chloride solution, dry over anhydrous magnesium sulfate, spin dry, recrystallize from methanol to obtain a light yellow solid (0.13g, yield 26%), melting point 226-228°C . IR(KBr)vcm-1: 2953, 2857, 1669, 1593, 1573, 1442, 819, ESI-MS: 290[M+Na]+, 1HNMR: 2.93(2H, s, -CH2), 6.10~6.13( 1H, d, -CH=C), 6.47~6.48(1H, d, ArH), 6.92~6.94(2H, d, ArH), 7.20~7.30(3H, m, -CH=C), 7.71(1H, S, -CH=N), 12.35 (1H, s, -NH)
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More 


