Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Combined drug and applications of combined drug as immuno-regulation agent

An immunomodulatory agent and drug technology, applied in the directions of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problem of not finding hydroxychloroquine sulfate and artemisinin, and achieve the effect of reducing the amount of use and reducing toxic and side effects

Active Publication Date: 2016-01-20
INST OF SCI & TECH GUANGDONG UNIV OF CHINESE MEDICINE
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It has not been found that hydroxychloroquine sulfate and artemisinin can be used in combination, especially as an immunomodulator in the treatment of autoimmune diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Combined drug and applications of combined drug as immuno-regulation agent
  • Combined drug and applications of combined drug as immuno-regulation agent
  • Combined drug and applications of combined drug as immuno-regulation agent

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0020] Experimental Example 1 Pharmacodynamics Experiment of Artemisinin and Hydroxychloroquine Sulfate in Combination Treatment of Immune Diseases

[0021] Hydroxychloroquine sulfate (Hydroxychloroquine Sulphate, HCQ, hereinafter referred to as H) is an important drug for clinical treatment of immune diseases, but it has obvious toxic and side effects, which limits its clinical application. In this experiment, artemisinin (Artemisinin, ART, hereinafter referred to as A) and hydroxychloroquine sulfate (hereinafter referred to as AH) were used to reduce the dosage of hydroxychloroquine sulfate, and the peripheral blood cytokines, cellular immune function, humoral immune function, non-specific Several aspects of immune function were used to evaluate the efficacy of AH after compatibility, and to compare it with that of hydroxychloroquine sulfate alone. The research results of this experiment are of great significance to the development of clinical application of AH in the treatm...

experiment example 2

[0152] Experimental Example 2 Artemisinin Acute Toxicity Test

[0153] To observe and study the toxic reaction of Kunming (KM) mice given artemisinin three times within 24 hours, within a certain period of time, and to understand the dose of acute toxicity.

[0154] 1. Materials

[0155] 1.1 Test product

[0156] 1.1.1 Artemisinin (Artemisinin, ART, hereinafter referred to as "A"): Sichuan Tongrentai Pharmaceutical Co., Ltd., batch number: 130602, purity 98.8%;

[0157] 1.1.2 Hydroxychloroquine Sulphate (Hydroxychloroquine Sulphate, HCQ, hereinafter referred to as "H"): Chongqing Kangle Pharmaceutical Co., Ltd., batch number: SQK-130403, purity 98.7%, base content 77.40%.

[0158] 1.2 Drug preparation

[0159] Use BS210S electronic balance (1 / 10,000) to weigh, add 2 to 3 drops of Tween 80 in a mortar, fully grind to make a suspension, and then dilute with distilled water to the concentration required for the experimental design. Pre-drug preparation.

[0160] 1.3 Animals ...

experiment example 3

[0172] Experimental example 3 hydroxychloroquine sulfate acute toxicity test

[0173] To observe and study the toxic reaction of hydroxychloroquine sulfate given to KM mice once by intragastric administration within a certain period of time, and to understand the dose of acute toxicity.

[0174] 1. Materials

[0175] Same as experimental example 2.

[0176] 2. Experimental method

[0177] D by pretest m (Maximum dose for 100% death) and Dn (minimum dose for 0% death) result, D m Take 4000mg / kg, D n Take 1500mg / kg, the group interval is 1:0.78, KM mice are randomly divided into 5 administration groups [4000mg / kg, 3120mg / kg, 2434mg / kg, 1898mg / kg, 1481mg / kg] and 1 vehicle control Group (purified water), 10 rats in each group, 5 rats for each ♀♂. Each group was intragastrically administered once at 10 mL / kg body weight; the symptoms, onset time, duration, death time, and near-death reaction of the mice were observed continuously for 6 hours after the administration. After t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Ld50aaaaaaaaaa
Ld50aaaaaaaaaa
Ld50aaaaaaaaaa
Login to View More

Abstract

The present invention provides a combined drug, which contains a first active ingredient artemisinin, a second active ingredient hydroxychloroquine sulfate, and an optionally pharmaceutically-acceptable excipient. According to the present invention, the combined drug can be effectively used for autoimmune disease treatment, and can reduce the hydroxychloroquine sulfate consumption under the premise of assurance of the unchanged efficacy even improvement of the efficacy so as to reduce the toxic-side effect of the hydroxychloroquine sulfate.

Description

technical field [0001] The invention relates to a combined medicine containing artemisinin, the active ingredients of which are artemisinin and hydroxychloroquine sulfate, and the combined medicine can be used as an immunomodulator for treating autoimmune diseases. Background technique [0002] Immune diseases are diseases caused by the imbalance of immune regulation and affecting the body's immune response. Among them, autoimmune diseases are the most typical immune diseases, common ones are systemic lupus erythematosus (SLE), rheumatoid arthritis (rheumatoid arthritis, RA), etc. Cytokines and other immune abnormalities. [0003] Hydroxychloroquine sulfate (HydroxychloroquineSulphate, HCQ) is a 4-aminoquinolone drug. In recent years, it has been widely used in the treatment of various autoimmune diseases, and has good curative effect. It is an important drug for clinical treatment of immune diseases. The drug has a long-term effect of preventing severe attacks in patient...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4706A61P37/02A61P19/02A61P29/00A61P17/00A61P21/00A61P13/12A61K31/366
Inventor 宋健平徐勤周玖瑶邓长生郑绍琴赖洁梅王振华关业枝张红英王琪袁捷
Owner INST OF SCI & TECH GUANGDONG UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com