Preparation method of crosslinked polyglutamic acid hydrogel

A technology of polyglutamic acid and hydrogel, which is applied in the field of low-concentration cross-linked polyglutamic acid hydrogel and its preparation, can solve the problems of inaccurate dosage, uneven distribution, instability, etc. The content is stable and consistent, and the effect of easy packaging

Active Publication Date: 2016-01-20
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Abstract
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Problems solved by technology

This unstable suspension brings many inconveniences in industrial production, such as uneven distribution, inaccurate dosage, and the need to mix again before use, etc.

Method used

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  • Preparation method of crosslinked polyglutamic acid hydrogel
  • Preparation method of crosslinked polyglutamic acid hydrogel
  • Preparation method of crosslinked polyglutamic acid hydrogel

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preparation example Construction

[0029] Table 1 Preparation of high-concentration cross-linked polyglutamic acid gel blocks

[0030]

[0031]

[0032] Preparation method of high-concentration cross-linked polyglutamic acid gel blocks: According to the data in Table 1, a certain amount of sodium polyglutamate and cross-linking agent were dissolved in deionized water, stirred and mixed, and kept in a water bath for a period of time to obtain a non-flowing High-concentration cross-linked polyglutamic acid gel blocks.

[0033] According to Table 2, stable uniformly dispersed low-concentration cross-linked polyglutamic acid hydrogels were prepared respectively.

[0034] Table 2 Stable uniformly dispersed low-concentration cross-linked polyglutamic acid hydrogel

[0035]

[0036]

[0037] Stable uniformly dispersed low-concentration cross-linked polyglutamic acid hydrogel preparation method: According to the data in Table 2, weigh a certain mass of high-concentration cross-linked polyglutamic acid gel ...

experiment example

[0039] 1. Stability test: the cross-linked polyglutamic acid hydrogel was left standing for 10 months

experiment example 1

[0041] Experimental Example 1 Dissolve 4.0 g of sodium polyglutamate with an average molecular weight of 1.2 million and 40 μL of 1,4-butanediol diglycidyl ether in 50 mL of deionized water, stir and mix, and keep warm in a water bath at 60 ° C for 4 hours to obtain a fluid State cross-linked polyglutamic acid (polyglutamic acid content 8%, 1,4-butanediol diglycidyl ether accounts for 1% by weight of polyglutamic acid). Inhomogeneous precipitates can be seen when stirred, and dark yellow precipitates are deposited at the bottom after a long period of storage. After stirring and mixing, absorb 4.2376g of the glue, in order to obtain a cross-linked polyglutamic acid hydrogel with a cross-linked polyglutamic acid content of 0.21%, calculate and add 161mL of deionized water, and homogenize in a crushing homogenizer, A dispersed cross-linked polyglutamic acid hydrogel was obtained.

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Abstract

The invention relates to crosslinked polyglutamic acid hydrogel and a preparation method thereof, wherein the crosslinked polyglutamic acid hydrogel is stable, uniform in dispersion and low in concentration. The preparation method comprises the following steps of firstly, adopting a high concentration crosslinking formula for preparing gamma-polyglutamic acid rubber blocks, then, adding a water-based solution for homogenizing and crushing the gamma-polyglutamic acid rubber blocks, and obtaining the crosslinked polyglutamic acid hydrogel which is stable, uniform in dispersion and low in concentration. The preparation method of the crosslinked polyglutamic acid hydrogel which is stable, uniform in dispersion and low in concentration is few in step, stable in product character and suitable for industrial production and application; by controlling the concentration of crosslinked polyglutamic acid in a product, series products with improved viscosity can be obtained, the products are prone to being hydrated so that the products can be uniformly applied to and dispersed on the skin surface, and no sticky or flaking phenomenon occurs to the skin surface.

Description

technical field [0001] The invention relates to a cross-linked polyglutamic acid hydrogel, in particular to a stable low-concentration cross-linked polyglutamic acid hydrogel in a uniform dispersion state and a preparation method thereof. Background technique [0002] γ-polyglutamic acid hydrogel is a polymer network that cross-links γ-polyglutamic acid (hereinafter referred to as polyglutamic acid) molecules and can maintain a large amount of water without dissolving after swelling in water. Wang Jingxin et al. (Progress in research and application of γ-polyglutamic acid hydrogel, Microbiology Bulletin, 2014) introduced that the cross-linking preparation methods of polyglutamic acid hydrogel include radiation and chemical cross-linking methods. Compared with radiation crosslinking, chemically crosslinked polyglutamic acid hydrogels have better performance and wider application. Due to its good water absorption and water retention, cross-linked polyglutamic acid can be used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L77/04C08K5/1515C08J3/24C08J3/075
Inventor 朱希强刘飞凌沛学李海军陈勉边玲于林艳孟祥璟郭欣陈晓燕袁丹丹张秀华张天骄王桂兰
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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