Application of solanum nigrum effective ingredients to preparation of drugs treating lithiasis
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An active ingredient and a technology for treating calculus, which is applied in the field of preparing medicines for treating calculus with active ingredients of Solanum nigrum, can solve problems such as difficult to ensure product safety, effectiveness and quality control
Active Publication Date: 2016-01-27
哈尔滨维康达生物科技有限公司
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[0003] In principle, the above-mentioned several Chinese herbal medicine formulas can be applied to the treatment of gallstones, but each formula contains many medicines. Due to the differenc
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[0006] The present invention will be further described below in conjunction with embodiment:
[0007] 1. After drying the whole herb or fruit of Solanum nigrum, take 10kg of room temperature and puff it with 30kg of ethanol solvent of 5%-95% for continuous extraction in a continuous tubular ultrasonic extraction device. The ultrasonic power is 8kw, and the extract is 25kg. -Ethanol-0.5mol / L sodium phosphate buffer solution prepares 100kg of solvent system in the ratio of 4:2:2:2, pumps 25kg of extract and 100kg of solvent system into the multidimensional flow ultrasonic liquid phase preparative chromatogram after being mixed uniformly, under pressure Separation and purification under the conditions of 0.1Mpa, ultrasonic power 500W, and electromagnetic cyclone power 1KW, respectively drying and preparing 350g of Solanum solanine with a yield of 3.5%, 20g of Solanum solanine with a yield of 0.2%, and Solanine with a yield of 0.2%. 25g, yield 0.25%.
[0008] 2. Solanine solanine...
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Abstract
The invention relates to application of solanum nigrum effective ingredients to preparation of drugs treating lithiasis. Solanum nigrum herb and fruits are adopted as the raw materials, drying, low-temperature continuous puffing, continuous ultrasonic extraction, and multidimensional flow ultrasonic liquid preparation chromatography purification are carried out to obtain three effective components, i.e. solanine, solasonine and solamargine, the substances are then modified by hydrochloric acid respectively so as to generate hydrochloric acid solanine salts, and the effective components are combined with an appropriate excipient to prepare a tablet, a capsule and a sustained-release capsule for treating lithiasis. The technology provided by the invention has the characteristics of high extraction efficiency, simple and practical purification process, and extensive use of prepared drugs, thus being suitable for industrial production.
Description
Technical field [0001] The invention relates to the preparation of medicines for curing calculi, in particular to the preparation of active ingredients of black nightshade for the preparation of medicines for curing calculus. Background technique [0002] Calculus is a common disease, including hepatolithiasis, urinary calculus, etc. Therefore, for a long time, people have researched and invented a variety of methods and medicines for treating calculus with traditional Chinese medicine. CN1868531 relates to a combination of traditional Chinese medicines for treating hepatolithiasis , the traditional Chinese medicine used is Bupleurum, Radix Paeoniae Alba, Polygonum cuspidatum, Citrus aurantium, branch, capillary, gallinacea, green bark, woody, turmeric, rhubarb, money grass, sea gold sand, pangolin, toosendan, dendrobium, amber, Chuanpu and Yuanhu et al.; in ZL200510042523, a traditional Chinese medicine for treating hepatolithiasis and its production method. Erbaohua, fire...
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