Salinomycin granule preparation preparation technology based on improvement of spraying effect

Abstract

The invention relates to a salinomycin granule preparation preparation technology based on improvement of the spraying effect. The preparation technology includes the following steps that acidic fermentation liquid is prepared, wherein the pH of salinomycin fermentation liquid is adjusted to 4.0-5.0 through acidic liquid; the acidic fermentation liquid is pre-processed, wherein the temperature of the acidic fermentation liquid with the pH adjusted is preserved for 3-4 h at the temperature of 60-65 DEG C; the pH is adjusted till the salinomycin fermentation liquid is alkaline, a saponification reaction is performed, and salinomycin material liquid is prepared, wherein a certain amount of light calcium carbonate is added into the prepared acidic fermentation liquid so that salinomycin material liquid can be prepared; spraying and drying are performed, wherein after spraying particles are added into the prepared salinomycin material liquid, granules are prepared through a spraying and drying method, and then a salinomycin granule preparation is obtained. The salinomycin granule preparation preparation technology solves the problems that an existing salinomycin granule preparation technology is low yield and not ideal in spraying effect.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation process of salinomycin granule preparation based on improving the spray effect. Background technique

[0002] Salinomycin is a polyether ionophore antibiotic produced by Streptomyces albus. Salinomycin granule preparation not only has good antibacterial effect, low toxicity and low residue, simple production process, readily available raw materials and low price, it is one of the most promising veterinary drugs recognized in the market.

[0003] Salinomycin has a strong inhibitory and killing effect on most Gram-positive bacteria and various coccidiosis, and it is not easy to produce drug resistance and cross-resistance. It is excreted quickly and the residual amount is extremely low. It can be used to prevent diarrhea, Promote production and increase survival rate. Salinomycin has a cation transport function in cells, especially for potassium ions, sodium ions, ...

Examples

Embodiment 1

[0021] The preparation process of the salinomycin granule preparation based on improving the spray effect comprises the following steps:

[0022] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 80,000u / ml to 4.0 with sulfuric acid;

[0023] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 60°C for 3 hours;

[0024] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 8.5, full saponification;

[0025] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation ...

Embodiment 2

[0028] The preparation process of the salinomycin granule preparation based on improving the spray effect comprises the following steps:

[0029] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 90000u / ml to 4.5 with sulfuric acid;

[0030] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 62°C for 3.5 hours;

[0031] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 9.0, fully saponified;

[0032] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation 15...

Embodiment 3

[0035] The preparation process of the salinomycin granule preparation based on improving the spray effect comprises the following steps:

[0036] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 100,000u / ml to 5.0 with sulfuric acid;

[0037] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 65°C for 4 hours;

[0038] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 9.5, full saponification;

[0039] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation ...

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation process of salinomycin granule preparation based on improving the spray effect. Background technique

[0002] Salinomycin is a polyether ionophore antibiotic produced by Streptomyces albus. Salinomycin granule preparation not only has good antibacterial effect, low toxicity and low residue, simple production process, readily available raw materials and low price, it is one of the most promising veterinary drugs recognized in the market.

[0003] Salinomycin has a strong inhibitory and killing effect on most Gram-positive bacteria and various coccidiosis, and it is not easy to produce drug resistance and cross-resistance. It is excreted quickly and the residual amount is extremely low. It can be used to prevent diarrhea, Promote production and increase survival rate. Salinomycin has a cation transport function in cells, especially for potassium ions, sodium ions, ...

Examples

Embodiment 1

[0021] The preparation process of the salinomycin granule preparation based on improving the spray effect comprises the following steps:

[0022] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 80,000u / ml to 4.0 with sulfuric acid;

[0023] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 60°C for 3 hours;

[0024] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 8.5, full saponification;

[0025] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation ...

Embodiment 2

[0028] The preparation process of the salinomycin granule preparation based on improving the spray effect comprises the following steps:

[0029] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 90000u / ml to 4.5 with sulfuric acid;

[0030] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 62°C for 3.5 hours;

[0031] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 9.0, fully saponified;

[0032] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation 15...

Embodiment 3

[0035] The preparation process of the salinomycin granule preparation based on improving the spray effect comprises the following steps:

[0036] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 100,000u / ml to 5.0 with sulfuric acid;

[0037] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 65°C for 4 hours;

[0038] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 9.5, full saponification;

[0039] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation ...