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Traditional Chinese medicine preparation for treating senile dementia, encephalatrophy and dysgnosia

A technology for mental retardation and senile dementia, applied in the field of medicine, can solve problems such as inability to cure, single target, and inability to improve the pathological state of neural tangles, etc., to improve memory, prevent and treat senile dementia, and improve cognitive dysfunction. Effect

Inactive Publication Date: 2016-02-17
张量才
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs have a good effect in improving symptoms, they cannot cure them completely, nor can they improve their pathological conditions such as neural tangles.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0012] Weigh 20 grams of antler, 20 grams of saffron, 70 grams of astragalus, 16 grams of cistanche, 15 grams of earthworm, 13 grams of turtle glue, 10 grams of leech, 25 grams of Phellodendron cork, 16 grams of dodder, 25 grams of Morinda officinalis, 20 grams of salvia miltiorrhiza, 22 grams of Chuanxiong, 20 grams of angelica tail, 25 grams of peach kernel, 20 grams of red peony root, 20 grams of Chuanduan, 20 grams of Achyranthes bidentata, 20 grams of Rhodiola rosea, 20 grams of Polygala, 20 grams of Angelica dahurica, 20 grams of Panax notoginseng, 20 grams of safflower gram, Caulis Spatholobus 20 grams, Rhizoma Drynariae 20 grams, Epimedium 20 grams and Rehmannia Rehmanniae 20 grams, pulverize, cross 100 mesh sieves, mix evenly to obtain powder.

experiment example

[0014] Preparation of thrombus suspension

[0015] Take 10 SD rats of the same species, 280-300g, half male and half female, under sterile conditions, collect blood through the ocular venous plexus, dry naturally, form a blood clot, grind it with a mortar and sieve through a 180 μm sieve for later use, apply When adding blood clots with normal saline to make 200mg / mL thrombus suspension. Its diameter was measured under a microscope, and it was found that the diameter of the embolus was 40-180 μm, and most of them were 130-180 μm.

[0016] Preparation of cerebral infarction model rats

[0017] Take 120 SD rats of the same species, 280-300 g, half male and half male, anesthetized with 3% pentobarbital (1 mL / 100 g). After anesthesia, the rats were placed supine and fixed on a flat plate. A median carotid incision was made to expose the left common carotid artery, the internal and external carotid arteries were separated, the common carotid artery was temporarily clamped with a ...

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Abstract

The invention relates to a traditional Chinese medicine preparation for treating senile dementia, encephalatrophy and dysgnosia. The traditional Chinese medicine preparation is prepared from the following substances in parts by weight: pilos antler, saffron crocus, astragalus membranaceus, herba cistanche, earthworms, turtle paste, hirudo, golden cypress, semen cuscutae, morinda officinalis, salvia miltiorrhiza, ligusticum wallichii, tail of Chinese angelica root, peach kernels, radix paeoniae rubra, dipsacaceae, radix achyranthis bidentatae, rhodiola rosea, polygala tenuifolia, radix angelicae, notoginseng, safflower carthamus, caulis spatholobi, rhizoma drynariae, epimedium and rehmannia glutinosa. According to the traditional Chinese medicine preparation, the cognition impairment can be improved, the cerebral atrophy can be delayed, the memory can be increased, and an obvious effect of preventing and treating the senile dementia is achieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for treating senile dementia, brain atrophy and mental retardation. Background technique [0002] Senile dementia includes vascular dementia and Alzheimer's disease (AD), and most of them are Alzheimer's disease patients. AD is a degenerative neurological disease characterized by progressive memory and cognitive impairment. The main clinical symptoms are progressive memory impairment, loss of cognitive function, and personality changes. Studies have shown that the main pathological features of AD are senile plaque deposition (senileplaque), neurofibrillary tangles (neurofibrillarytangle, NFT) and neuron loss and degeneration in the brain. Early studies have found that memory impairment and loss of cognitive function in AD patients are closely related to changes in central neurotransmitters, especially the reduction of cholinergic neurotransmitters and monoa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K31/429A61P25/28A61K35/62A61K35/32A61K35/586
Inventor 张量才
Owner 张量才
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