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A 3D printing system and method for a reinforced hollow gel tube with a coaxial nozzle

A coaxial nozzle, 3D printing technology, applied in 3D object support structures, additive processing, coating devices, etc., can solve the problem of difficult to meet the requirements of biological manufacturing, difficult to ensure the coaxiality of the inner and outer tubes, hollow circular tubes, etc. Poor mechanical strength and other problems, to achieve the effect of simple structure, reliable performance and uniform wall thickness

Active Publication Date: 2018-03-02
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the material is squeezed in the nozzle and exerts force on the inner tube to deform it, it is difficult to ensure the coaxiality of the inner and outer tubes at the front end of the nozzle.
In particular, when a small inner tube diameter is used, the coaxiality is more difficult to ensure, so the size of the nozzle cannot be small, which restricts the size of the hollow gel tube
[0004] In the existing process of using sodium alginate to manufacture hollow gel tubes, the hollow tubes formed only through the cross-linking reaction of sodium alginate and calcium ions have poor mechanical strength, which is difficult to meet the requirements of biomanufacturing

Method used

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  • A 3D printing system and method for a reinforced hollow gel tube with a coaxial nozzle
  • A 3D printing system and method for a reinforced hollow gel tube with a coaxial nozzle
  • A 3D printing system and method for a reinforced hollow gel tube with a coaxial nozzle

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Experimental program
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Effect test

Embodiment 1

[0047] Choose a coaxial nozzle with inner tube inner diameter of 0.34mm and outer diameter of 0.63mm; outer tube inner diameter of 1.12mm and outer diameter of 1.48mm. The concentration of sodium alginate solution is 2%-4% (w / v), and the concentration of calcium chloride solution is 4% (w / v), the concentration of ferric chloride solution is 0.25% (w / v). The extrusion rate of the sodium alginate solution is 1.5ml / min, that of the calcium chloride solution is 1-3ml / min, and that of the ferric chloride is 4.5ml / min. Reinforced hollow gel tubes with an outer diameter of 800-1200 μm can be printed.

Embodiment 2

[0049] Choose a coaxial nozzle with inner tube inner diameter of 0.24mm and outer diameter of 0.45mm; outer tube inner diameter of 0.70mm and outer diameter of 1.06mm, the concentration of sodium alginate solution is 2%-4% (w / v), and the concentration of calcium chloride solution The concentration is 4% (w / v), and the concentration of ferric chloride solution is 0.25% (w / v). The extrusion rate of the sodium alginate solution is 1.5ml / min, that of the calcium chloride solution is 1-3ml / min, and that of the ferric chloride is 4.5ml / min. Reinforced hollow gel tubes with an outer diameter of 500-800 μm can be printed.

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Abstract

The invention discloses a 3D printing system and process of a coaxial nozzle and a reinforced hollow gel tube thereof. The 3D printing system includes a 3D printing platform, two sets of feeding devices, a coaxial nozzle, a spray device and a control system; further, the coaxial nozzle consists of an inner tube, an outer tube, two feeding ports, a sealing gasket and a weldment. By adopting the coaxial nozzle provided by the present invention, the coaxiality of the inner and outer tubes at the front end of the nozzle is better ensured by using the welding parts, and the sealing gasket ensures the airtightness between the inner and outer tubes. The printing process of the enhanced hollow gel tube uses ferric chloride spray to further react with the hollow gel tube to enhance the mechanical strength of the hollow gel tube. The invention installs the coaxial nozzle and the spray device on the XY printing platform, the control system controls the operation of the printing platform, the feeding device and the spray device, and combines the printing process of the enhanced hollow gel tube to form the enhanced hollow gel tube printing.

Description

technical field [0001] The invention belongs to the intersecting field of mechanical automation, biotechnology and tissue engineering, and specifically relates to a 3D printing system and method of a reinforced hollow gel tube with a coaxial nozzle. Background technique [0002] Due to the lack of effective vascular network to transport nutrients and metabolic wastes, artificial tissues are difficult to produce large-scale and complex structures. Printing hollow gel tubes during tissue printing can effectively help transport nutrients and waste, acting as a vascular network. The printing system based on coaxial nozzles can print hollow gel tubes, but there are the following problems: [0003] Existing coaxial nozzles utilize the upper ends or middle parts of inner and outer pipes to ensure coaxiality. When the material is squeezed in the nozzle and exerts force on the inner tube to deform it, it is difficult to ensure the coaxiality of the inner and outer tubes at the fron...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/106B29C64/20B29C64/209B29C64/336B33Y10/00B33Y30/00B33Y40/00
Inventor 连芩毛伟李晓李涤尘贾书海
Owner XI AN JIAOTONG UNIV