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Swept-source-based correction method of phase errors in optical coherence tomography

A technology of optical coherence tomography and scanning imaging, which is applied in the direction of using tomography for diagnosis, diagnosis, medical science, etc. It can solve the problems of phase instability interference spectrum signal, data acquisition card circuit offset, instability, etc. Real-time correction, small amount of calculation, small change effect

Active Publication Date: 2016-02-24
无锡欧因特光学科技有限公司
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Problems solved by technology

In the SS-OCT system, the phase instability is mainly reflected in the front and back shift of the measured interference spectrum signal in the wave number space, which is mainly caused by the signal acquisition trigger signal provided by the sweeping light source and the k clock signal. Due to relative instability, the data acquisition card circuit itself may also cause the above-mentioned offset

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  • Swept-source-based correction method of phase errors in optical coherence tomography
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  • Swept-source-based correction method of phase errors in optical coherence tomography

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Embodiment Construction

[0026] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0027] In SS-OCT, the swept source provides the trigger signal and k clock (sampling clock) for signal acquisition. The biggest difference from the second-generation spectral domain OCT is that SS-OCT uses the k clock as the sampling clock for signal acquisition, so that the collected interference spectrum signals are linearly and uniformly distributed in the wavenumber space, which can greatly simplify the later signal processing. On the other hand, the main defect of using the k clock as the sampling clock is the relative instability between the trigger signal and the k clock, which is specifically manifested in the relative shift of the continuously collected interference spectrum in the wavenumber space, and this shift can reach several clock ...

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Abstract

The invention discloses a swept-source-based correction method of phase errors in optical coherence tomography. The method includes: (1), performing discrete Fourier transform on interference spectra, and modulating original interference signals of optical coherence tomography; (2), utilizing phase distribution of modulated signals of the original interference signals of optical coherence tomography to detect offset of original interference spectrum signals; (3), correcting offset of the original interference spectrum signals of optical coherence tomography. The method is a novel method for correcting phase errors caused by inside shaking of electronic equipment in real time in an SS-OCT system adopting a k clock provided by a swept source as a sampling clock, and is feasible and effective, a guarantee is provided for accurately measuring human tissue blood flow, the method plays an important role in assisting medical clinical diagnosis and treatment, quality of OCT angiography images based on phase resolution and accuracy of blood flow speed measuring are improved, and removal effect of fixed pattern noise is improved.

Description

technical field [0001] The invention relates to a method for correcting phase errors in optical coherence tomography imaging based on a swept-frequency light source, in particular to the use of an optical coherence tomography imaging system in biological tissue and human blood vessel imaging. Background technique [0002] Optical coherence tomography (OCT) is a low-coherence optical interference imaging technique. It is capable of three-dimensional imaging of the scattering structure of biological tissues such as the human body. This technology has great potential in detecting diseases in fundus retina, digestive tract system, arteries and skin, etc. At present, the more mature function of OCT technology is to image the static scattering structure. In addition, OCT also has other extensional functions. Among them, the extended function imaging that has been studied more is the blood flow imaging in biological tissues such as the human body. Usually Called optical coherence...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0066A61B5/0073
Inventor 莫建华尤哈尼斯·德波尔钱婕
Owner 无锡欧因特光学科技有限公司
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