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A kind of atorvastatin calcium tablet and preparation method thereof

A technology of atorvastatin calcium and tablets, applied in the field of medicine, can solve problems such as reducing the incidence of major cardiovascular events, and achieve the effect of meeting clinical needs

Active Publication Date: 2018-03-30
SHIJIAZHUANG HUAXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It significantly reduces the incidence of major cardiovascular events (primary endpoint events)

Method used

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  • A kind of atorvastatin calcium tablet and preparation method thereof
  • A kind of atorvastatin calcium tablet and preparation method thereof
  • A kind of atorvastatin calcium tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 atorvastatin calcium tablet of the present invention (specification 10mg / sheet, 1000)

[0022] Chip composition:

[0023]

[0024] Coating composition:

[0025]

[0026] Preparation:

[0027] (1) Pretreatment: pass hypromellose acetate succinate, ammonium oxalate, lactose FlowLac100, hypromellose, magnesium stearate and Opadry YS-1-7040 through a 40-mesh sieve, and follow the prescription amount Weigh, reserve;

[0028] (2) Total blending: Take atorvastatin calcium, hypromellose acetate succinate, ammonium oxalate, lactose FlowLac100, hypromellose, magnesium stearate, and mix in a mixer for 15 minutes;

[0029] (3) Tablet compression: perform tablet compression with a high-speed rotary tablet press to obtain tablet cores;

[0030] (4) Coating: Take Opadry YS-1-7040, sodium lauryl sulfate, and lauryl dimethylamine oxide, make a coating solution with purified water, and place the tablet core in the coating pan Inside, adjust the...

Embodiment 2

[0031] Embodiment 2 Preparation of atorvastatin calcium tablet according to the present invention (specification 20mg / tablet, 1000 tablets)

[0032] Chip composition:

[0033]

[0034] Coating composition:

[0035]

[0036] Preparation:

[0037] (1) Pretreatment: pass hypromellose acetate succinate, ammonium oxalate, lactose FlowLac100, hypromellose, magnesium stearate and Opadry YS-1-7040 through a 40-mesh sieve, and follow the prescription amount Weigh, reserve;

[0038] (2) Total blending: Take atorvastatin calcium, hypromellose acetate succinate, ammonium oxalate, lactose FlowLac100, hypromellose, magnesium stearate, and mix in a mixer for 15 minutes;

[0039] (3) Tablet compression: perform tablet compression with a high-speed rotary tablet press to obtain tablet cores;

[0040](4) Coating: Take Opadry YS-1-7040, sodium lauryl sulfate, and lauryl dimethylamine oxide, make a coating solution with purified water, and place the tablet core in the coating pan Insid...

Embodiment 3

[0041] Embodiment 3 Preparation of atorvastatin calcium tablet according to the present invention (specification 30mg / tablet, 1000 tablets)

[0042] Chip composition:

[0043]

[0044] Coating composition:

[0045]

[0046] Preparation:

[0047] (1) Pretreatment: pass hypromellose acetate succinate, ammonium oxalate, lactose FlowLac100, hypromellose, magnesium stearate and Opadry YS-1-7040 through a 40-mesh sieve, and follow the prescription amount Weigh, reserve;

[0048] (2) Total blending: Take atorvastatin calcium, hypromellose acetate succinate, ammonium oxalate, lactose FlowLac100, hypromellose, magnesium stearate, and mix in a mixer for 15 minutes;

[0049] (3) Tablet compression: perform tablet compression with a high-speed rotary tablet press to obtain tablet cores;

[0050] (4) Coating: Take Opadry YS-1-7040, sodium lauryl sulfate, and lauryl dimethylamine oxide, make a coating solution with purified water, and place the tablet core in the coating pan Insi...

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Abstract

The invention relates to an atorvastatin calcium tablet and a preparation method thereof, and belongs to the technical field of a medicine. The atorvastatin calcium tablet consists of a tablet core and a coating, wherein the tablet core is prepared from atorvastatin calcium, a protective agent, a filling agent, a disintegrant and a lubricant; and the coating is prepared from opadry YS-1-7040, a pore-foaming agent and purified water. On the basis of a stability investigation for 36 months, property, dissolution rate, content and relative substances of the atorvastatin calcium tablet disclosed by the invention have no significant difference with that on the 0th day, and are within qualified ranges and conforming to quality requirement. Therefore, the atorvastatin calcium tablet disclosed by the invention, through special formula proportioning and the special preparation process, achieves a good technical effect; and a different technical scheme, which can better meet clinical demand, is provided for the preparation of the atorvastatin calcium tablet.

Description

technical field [0001] The invention relates to a tablet and a preparation method thereof, in particular to an atorvastatin calcium tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] With the acceleration of the aging society, chronic diseases such as coronary heart disease, angina pectoris, and "three highs" have become fatal killers for people. How to effectively treat chronic diseases has become a topic of concern. The traditional treatment methods used clinically, such as the use of cilostazol tablets, usually have no obvious effect and a high incidence of adverse reactions, and chronic diseases generally occur in middle-aged and elderly people. Such patients have declining physiological functions and many complications. It is more likely to lead to adverse reactions, so accurate selection of clinical medication is the key to treatment. Atorvastatin is a selective HMG-CoA reductase inhibitor that reduces ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K31/40A61K47/38A61K47/18A61K47/20A61P3/06A61P9/10A61P9/12A61P3/10A61P13/12
CPCA61K9/2866A61K31/40A61K47/18A61K47/186A61K47/20A61K47/38
Inventor 马海波李明海李志鹏周如亮
Owner SHIJIAZHUANG HUAXIN PHARMA