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Application of Erding granules in preparation of drugs for treating or preventing hyperuricemia and gout diseases

A technology of hyperuricemia and granules, which can be used in drug combinations, bone diseases, pharmaceutical formulations, etc., and can solve problems such as allergic dermatitis, gastrointestinal reactions, and side effects of sulfonamide drugs.

Inactive Publication Date: 2016-02-24
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical drugs currently used to treat this disease—western medicine, although they can inhibit the production of uric acid and reduce the production and synthesis of uric acid in the body, they have adverse reactions such as inhibition of bone marrow function, gastrointestinal irritation, and allergic drug eruption; drugs that promote uric acid excretion Can promote renal tubular excretion of uric acid, but this type of drug has side effects of sulfa drugs, often causing allergic dermatitis and gastrointestinal reactions

Method used

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  • Application of Erding granules in preparation of drugs for treating or preventing hyperuricemia and gout diseases
  • Application of Erding granules in preparation of drugs for treating or preventing hyperuricemia and gout diseases
  • Application of Erding granules in preparation of drugs for treating or preventing hyperuricemia and gout diseases

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Effect test

Embodiment 1

[0013] Embodiment 1: Experimental method of Erding Granules on serum uric acid in mice with hyperuricemia

[0014] (1) Experimental method for mice with hyperuricemia induced by potassium oxonate (single dose model)

[0015] 60 male KM mice were randomly divided into 6 groups, normal group, model group, allopurinol group, Erding Granules (10, 20, 40g raw medicinal materials / kg) three dosage groups, 10 in each group, normal group And the model group was intragastrically administered normal saline, the allopurinol group was intragastrically administered 15mg / kg allopurinol, and the three dose groups of Erding granule were intragastrically administered Erding granule extract, once a day for 5 consecutive days. One hour before the last administration, except the normal group, the animals in the other groups were intraperitoneally injected with 450 mg / kg oxonate potassium to establish the hyperuricemia model [7] The normal group was injected with an equal volume of 0.5% CMC-Na. ...

Embodiment 2

[0022] Embodiment 2: The experimental method of Erding Granules on serum uric acid in rats with hyperuricemia

[0023] 60 rats were randomly divided into three groups: normal group, model group, high, medium and low doses of allopurinol and Erding Granules (24, 12, 6 g / kg), 6 groups in total, 10 rats in each group. The model group and the normal group were intragastrically administered the same volume of normal saline, and the other drug groups were intragastrically administered the corresponding drug solution, 1ml / 100g body weight, for 5 consecutive days. Hypoxanthine 500mg / kg was administered orally, and oxonic acid potassium salt 100mg / kg was injected subcutaneously to establish a hyperuricemia model. The last administration was performed 1 hour after the model was established, and the positive drug (allopurinol) was given only at this time. The drug was taken once, blood was collected 2 hours after administration, centrifuged at 3500r / min for 10 minutes, serum was collec...

Embodiment 3

[0026] Embodiment 3: Experimental method of Erding Granules on hyperuricemia quail serum uric acid

[0027] 50 quails were randomly divided into normal group, model group, large and small doses of Erding granule group (10, 5g / kg), benzbromarone group (20mg / kg), 5 groups in total, 10 quails in each group. Except for the normal group fed with common quail feed, all other groups were given high-purine feed (common feed mixed with yeast dry powder 15g kg -1 d -1 , supplemented with ordinary feed after eating), free drinking water. The normal group and the model group were administered with 0.5% CMC-Na, and the other groups were administered with corresponding drugs, 10ml / kg, and the experimental period was 14 days. After 14 days of administration, fasting and water for 12 hours before blood collection, 1ml of blood was collected from the jugular vein, after standing for 1 hour, centrifuged at 3500r / min for 10 minutes, serum was collected, and uric acid was detected by an autom...

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Abstract

The invention provides an application of Erding granules in preparation of drugs for treating or preventing hyperuricemia and gout diseases. Provided evidences indicate that the Erding granules have new application of obviously preventing and treating hyperuricemia and gout diseases. The Erding granules are disclosed to have obvious hypouricemic effect, so as to reduce serum uric acid values of hyperuricemia and gout diseases and alleviate clinical symptoms of patients with gout.

Description

technical field [0001] The invention relates to the new application of Erding Granules, in particular to the application of Erding Granules in the preparation of medicines for treating or preventing hyperuricemia and gout. Background technique [0002] Uric acid is the end product of purine metabolism, and a stable uric acid level involves the balance between uric acid production, absorption, excretion, and decomposition. Once the above process is disturbed, it will lead to increased uric acid production or decreased excretion, causing hyperuricemia (HUA). When the crystals are deposited in the distal joints, it can cause acute synovitis of single or multiple joints; when the uric acid crystals are deposited in the subcutaneous area, it can form gouty nodules, and severe gout can lead to joint destruction and impaired renal function. According to statistics, about 5% to 12% of patients with hyperuricemia eventually develop into gout (gout). In recent years, some studies ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61P19/06
Inventor 杨世林冯育林李俊张武岗简辉左洁羽王木兰许溪
Owner JIANGXI HERBFINE HI TECH
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