Unlock instant, AI-driven research and patent intelligence for your innovation.

Zhonghua ganling capsule and preparation method thereof

A technology of vinegar preparation and traditional Chinese medicine, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of slow disintegration, unsatisfactory curative effect, and low curative effect.

Inactive Publication Date: 2016-03-16
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commercially available Zhonghuaganling Capsules have unsatisfactory curative effect due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Zhonghua ganling capsule and preparation method thereof
  • Zhonghua ganling capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take patchouli 222g, pomegranate peel 111g, Bupleurum (vinegar) 60g, Magnolia officinalis (ginger) 300g, Sanqi 40g, angelica 333g, Chuanxiong 111g, turtle shell (vinegar) 200g, turmeric 180g, green skin ( Vinegar) 333g, citrus aurantium (stir-fried bran) 270g, crushed into 60-mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 19Mpa, extraction temperature 15°C, separator pressure 11Mpa, separator temperature 35°C, separation time After 2.6 hours, the flow rate of carbon dioxide is 24L per hour to obtain the extract; take the extract and dry it under reduced pressure at 61°C to obtain a dry paste; add 150g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take mixed dry paste powder, microcrystalline cellulose 45g, cross-linked polyvinylpyrrolidone 45g, cross-linked carmellose sodium 35g, mix well, wet granulate with 50% ethanol, d...

specific Embodiment 2

[0031] Take patchouli 222g, pomegranate peel 111g, Bupleurum (vinegar) 60g, Magnolia officinalis (ginger) 300g, Sanqi 40g, angelica 333g, Chuanxiong 111g, turtle shell (vinegar) 200g, turmeric 180g, green skin ( Vinegar) 333g, citrus aurantium (stir-fried bran) 270g, crushed into 60-mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 40Mpa, extraction temperature 43°C, separator pressure 19Mpa, separator temperature 60°C, separation time 3.4 hours, the flow rate of carbon dioxide is 36L per hour to obtain the extract; take the extract and dry it under reduced pressure at 75°C to obtain a dry paste; add 200g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take the mixed dry paste powder, microcrystalline cellulose 55g, cross-linked polyvinylpyrrolidone 55g, cross-linked carmellose sodium 45g, mix well, wet granulate with 70% ethanol, dry...

Embodiment 3

[0033] Take patchouli 222g, pomegranate peel 111g, Bupleurum (vinegar) 60g, Magnolia officinalis (ginger) 300g, Sanqi 40g, angelica 333g, Chuanxiong 111g, turtle shell (vinegar) 200g, turmeric 180g, green skin ( Vinegar) 333g, citrus aurantium (stir-fried bran) 270g, crushed into 60-mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 30Mpa, extraction temperature 29°C, separator pressure 15Mpa, separator temperature 48°C, separation time For 3 hours, the carbon dioxide flow rate is 30L per hour to obtain the extract; take the extract and dry it under reduced pressure at 68°C to obtain a dry paste; add 175g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take mixed dry paste powder, microcrystalline cellulose 50g, cross-linked polyvinylpyrrolidone 50g, cross-linked carmellose sodium 40g, mix well, wet granulate with 60% ethanol, dry at 7...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a Zhonghua ganling capsule and a preparation method thereof. The Zhonghua ganling capsule is characterized by being prepared from the following medicinal materials by weight: 222g of pogostemon cablin, 111g of pomegranate bark, 60g of radix bupleuri (processed with vinegar), 300g of mangnolia officinalis (processed with ginger), 40g of pseudo-ginseng, 333g of radix angelica sinensis, 111g of rhizoma chuanxiong, 200g of turtle shell (processed with vinegar), 180g of radix curcumae, 333g of pericarpium citri reticulatae viride (processed with vinegar), and 270g of immature bitter orange (stir-fried with bran). The preparation method comprises the following steps: extracting by adopting a carbon dioxide supercritical extraction method, carrying out drying under reduced pressure, grinding by adopting a high-energy nanometer impact mill to obtain dry nanometer paste, and adding functional auxiliary materials into the dry nanometer paste, thus preparing the Zhonghua ganling capsule. The Zhonghua ganling capsule and the preparation method have the advantages that the disintegration time is obviously shortened, the curative effect of the Zhonghua ganling capsule is obviously superior to that of the commercially available Zhonghua ganling capsule, and positive effects are achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Zhonghuaganling capsule and a preparation method thereof. Background technique [0002] Zhonghua Ganling Capsule soothes the liver and strengthens the spleen, regulates qi and relieves pain, activates the middle blood to remove blood stasis, softens hard masses and resolves stagnation. For liver stagnation of qi stagnation and blood stagnation, persistent accumulation, hypochondriac distending pain, lack of appetite, loose stools, cold spots on the tongue, deep, astringent and weak pulse. The commercially available Zhonghua Ganling Capsules has unsatisfactory curative effect due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect. Contents of the invention [0003] In order to overcome the above-mentioned disadvantages, the present invention provides ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K36/9066A61P1/16A61P1/14A61K35/586
CPCA61K9/4866A61K35/586A61K36/185A61K36/232A61K36/233A61K36/236A61K36/258A61K36/53A61K36/575A61K36/752A61K36/9066A61K2236/37
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD