A kind of preparation method of sulfonated alginic acid modified biological polyester film

A bio-polyester, sulfonation technology, applied in chemical instruments and methods, membrane, membrane technology, etc., can solve problems such as unsatisfactory blood compatibility

Active Publication Date: 2019-04-05
JIAXING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the blood compatibility of conventional synthetic polymer carrier materials such as polyvinyl alcohol and polystyrene is not ideal.

Method used

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  • A kind of preparation method of sulfonated alginic acid modified biological polyester film
  • A kind of preparation method of sulfonated alginic acid modified biological polyester film
  • A kind of preparation method of sulfonated alginic acid modified biological polyester film

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Embodiment Construction

[0017] The technical solution of the present invention is described in detail below. The embodiment of the present invention is only for illustrating a specific structure, and the scale of the structure is not limited by the embodiment.

[0018] figure 1 It is a flow chart of the method of the present invention, and provides a schematic illustration of the preparation method provided by the present invention.

[0019] The first step: preparation of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3,4HB)) microporous membrane.

[0020] Dissolve 5g of P(3,4HB) and 2g of PVP K-30 in 70ml of chloroform, let it stand for degassing, and apply a film on a glass plate with a 600μm frame-type film applicator. Shake and wash at room temperature for 24 hours (change the ethanol every 2 hours), take out the film, and rinse repeatedly with ethanol to completely extract the PVP K-30 porogen, and then dry the film in a vacuum oven at 50°C for 24 hours to obtain P(3,4HB) microporous membran...

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Abstract

The invention provides a preparation method for a sulfated alginic acid modified biological polyester film. With poly-(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3,4HB)) as the base material, the preparation method includes the following steps that 1, a P(3,4HB) microporous film is prepared through a dissolution method; 2, the obtained P(3,4HB) microporous film is subjected to ultraviolet graft polymerization, and hydroxyethyl acrylate (HEA) is introduced so that hydroxyl at a certain density can be generated on the film surface; 3, the HEA graft-modified P(3,4HB) microporous film is crosslinked with sulfated sodium alginate (SAS), and then the sulfated alginic acid modified biological polyester film with carboxyl and sulfonyl enriched on the surface is obtained. The sulfated alginic acid modified P(3,4HB) film prepared through the preparation method has the selective adsorption function on low-density lipoprotein (LDL) and is good in blood compatibility.

Description

technical field [0001] The invention relates to a preparation method of a sulfonated alginic acid modified biological polyester film, in particular to a sulfonated alginic acid modified poly(3-hydroxybutyrate- The invention discloses a preparation method of a microporous membrane (co-4-hydroxybutyrate), which belongs to the field of polymer materials. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the main diseases that threaten human health and life, and the number of people who die from them accounts for one-fourth to one-third of the total number of deaths every year in the world. Medical research and clinical practice have shown that high levels of Low Density Lipoprotein (LDL) in human blood will accelerate the deposition of cholesterol on the blood vessel wall, which is the cause of atherosclerosis and various cardiovascular and cerebrovascular diseases. main reason. Using blood purification therapy to selectively separate and re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/82B01D67/00B01D69/02A61M1/16
CPCA61M1/16B01D67/0006B01D67/0093B01D69/02B01D71/82B01D2323/28B01D2323/30B01D2323/345B01D2323/385
Inventor 汪蔚王玲孟晨洁许汝南邵文君
Owner JIAXING UNIV
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