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Single/multiple-component droplet preparation device based on integrated micro-channels and control method of single/multiple-component droplet preparation device

A technology for preparing devices and microchannels, which is applied in the direction of fluid controllers, measuring tubes/pipettes, chemical instruments and methods, etc., can solve the problems of long production cycle, unfavorable industrial production, and high cost, and achieve a small number of pumps, Simple structure and operation, good monodispersity effect

Active Publication Date: 2016-03-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production cycle and high cost of the microchannel equipment required to manufacture stepped emulsification by photolithography and other processing methods are not conducive to actual industrial production

Method used

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  • Single/multiple-component droplet preparation device based on integrated micro-channels and control method of single/multiple-component droplet preparation device
  • Single/multiple-component droplet preparation device based on integrated micro-channels and control method of single/multiple-component droplet preparation device
  • Single/multiple-component droplet preparation device based on integrated micro-channels and control method of single/multiple-component droplet preparation device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 single-component aqueous phase droplet

[0048] (1) The continuous phase is selected as silicone oil, and the discrete phase is deionized water. Add 5% mass fraction of surfactant (Dow Corning 749) to the silicone oil, and put it in a continuous phase container. Add a small amount of rhodamine b to deionized water and fill into a syringe.

[0049] (2) A preparation device for making single-component liquid droplets according to the above method. The distance between the two splints of the discrete phase outlet joint is h=0.3mm, and the distance between the microchannel outlet and the underside of the discrete phase outlet joint is 1.3mm. In this example, two channels (3rd and 6th) are used to prepare droplets at the same time. In this example, the flow rate of deionized water is set to 5mL / h as required. Turn on the syringe pump and adjust to the stated flow.

[0050] (3) After the deionized water reaches the outlet joint of the discr...

Embodiment 2

[0051] Determination of Mechanism Transition Critical Flow Rate during Example 2 Single-channel Droplet Preparation

[0052] (1) The continuous phase is selected as silicone oil plus 5% Dow Corning 749, and the discrete phase is deionized water plus a small amount of rhodamine b. The viscosity of water is 1.005mPa·s, the surface tension between silicone oil and water is about 2mN / m, and the inner diameter of the channel is 500 microns.

[0053] (2) A preparation device for making single-component liquid droplets according to the above method. The distance between the two splints of the discrete phase outlet joint is h=0.3mm, and the distance between the microchannel outlet and the underside of the discrete phase outlet joint is 1.3mm.

[0054] (3) In this embodiment, a single channel is used to prepare droplets, and the flow rate is between 2mL / hr and 66mL / hr, and a value is taken every 4mL / hr. The obtained droplet size is as follows Figure 8 shown. It can be seen that whe...

Embodiment 3

[0055] The preparation of embodiment 3 two-component aqueous phase droplets

[0056] (1) Select the continuous phase as silicone oil, add 5% mass fraction of surfactant (Dow Corning 749) into the silicone oil, and put it in the continuous phase container. The first discrete phase was selected as deionized water with a small amount of rhodamine b added and loaded into a syringe. The second discrete phase was chosen as deionized water with a small amount of Nile blue added and loaded into another syringe.

[0057] (2) A preparation device for making two-component liquid droplets according to the above method. The distance between the two splints of the discrete phase outlet joint is h=0.3mm, and the distance between the microchannel outlet and the underside of the discrete phase outlet joint is 1.3mm. In this embodiment, two channels are used to prepare two-component droplets, and the two channels are respectively connected to deionized water added with rhodamine b and deioniz...

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Abstract

The invention discloses a single / multiple-component droplet preparation device based on integrated micro-channels and a control method of the single / multiple-component droplet preparation device. The device comprises a micro-channel plastic film, a dispersed phase inlet joint, a dispersed phase outlet joint, a continuous phase container, an injection pump and the like, wherein one end of the micro-channel plastic film is connected with the dispersed phase inlet joint, the other end is connected with the dispersed phase outlet joint, the dispersed phase inlet joint is connected with the injection pump, and the dispersed phase outlet joint is immersed in the container filled with a continuous phase. A dispersed phase is pushed by the injection pump to flow and the flow is controlled, so that dispersed phase droplets can be generated in the continuous phase container. Monodispersed droplets can be generated rapidly with a large flux, multiple-component droplets can be prepared, and the device is expected to be applied to the fields of drug preparation, chemical synthesis, biomedicine and the like.

Description

technical field [0001] The invention relates to the field of microfluidics and the technical fields of chemical industry and biopharmaceuticals, in particular to a single / multi-component droplet preparation device based on an integrated microchannel and a control method thereof. Background technique [0002] Liquid droplets have been widely used in the fields of drug particle preparation, medical detection and analysis, and fine chemical industry. At present, the methods for preparing droplets mainly include microfluidic preparation method, spray method and capillary droplet control method. Among them, the microfluidic method uses some special fluid flow mechanisms in the microchannel structure to prepare droplets. The droplets produced by it have high uniformity in size and strong controllability, which has significant advantages compared with other methods. [0003] The methods for preparing droplets by microfluidics mainly include T-channel method, fluid focusing method ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/02
CPCB01L3/0251B01L3/0268B01L2200/027B01L2200/061B01L2300/0838B01L2300/0864B01L2400/0406B01L2400/088
Inventor 许忠斌陈东黄兴崔赟
Owner ZHEJIANG UNIV
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