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Traditional Chinese medicine compound preparation for treating endometriosis and preparation method thereof

A technology of endometrium and compound preparations, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve the problems of incurability, large side effects of hormone drugs, and high recurrence rate

Inactive Publication Date: 2016-04-20
THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The western medicines currently used are mainly hormonal drugs, such as GnRHas, danazol, nametone, tamoxifen, mifepristone, etc. Although they can temporarily relieve symptoms, they cannot cure the symptoms, and the recurrence rate is high after drug withdrawal. Practical problems such as large side effects and high costs of drugs make it difficult for patients to accept

Method used

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  • Traditional Chinese medicine compound preparation for treating endometriosis and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating endometriosis and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating endometriosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1 prepares the Chinese medicine compound preparation for the treatment of endometriosis

[0068] Take the raw materials of the following composition: angelica, chuanxiong, sunburned astragalus, salvia miltiorrhiza, hot leech, red peony root, xu changqing, saponin thorn, epimedium, peach kernel, wood beetle, vinegar cyperus, vinegar corydalis, and dried blood; The extract of each bulk drug is made into granules; wherein,

[0069] Preparation of cypress cyperus formula granules: take 20kg of cyperaceae, add water and decoct twice, decoct for 1 hour for the first time, decoct for 0.5 hours for the second time, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.05-1.07 (60°C) Clear the ointment, spray dry it, mix it evenly, make 1000g, pack it separately, and get it;

[0070] Preparation of Xu Changqing formula granules: take 10kg of Xu Changqing, add water and decoct twice, each time for 1 hour, combine the decoction, filter...

Embodiment 2

[0087] The extracts of the formula raw materials are respectively used to make granules, wherein,

[0088] Vinegar Cyperus 12g, Xu Changqing 15g, Vinegar Corydalis 12g, Sunburned Astragalus 15g, Angelica 12g, Saponaria thorn 12g, Peach Kernel 12g, Salvia miltiorrhiza 15g, Radix Paeoniae Rubra 12g, Hot Leech 12g, Wood Beetle 12g, Chuanxiong 12g, Epimedium 15g , blood 1g;

[0089] Preparation of Vinegar Cyperus Formula Granules: Take Vinegar Cyperi, add water to decoct twice, decoct for 1 hour for the first time, decoct for 0.5 hours for the second time, combine the decoction, filter, and concentrate the filtrate to a clear liquid with a relative density of 1.05-1.07 (60°C). Ointment, spray-dried, mixed evenly, sub-packaged to obtain;

[0090] Preparation of Xu Changqing formula granules: take Xu Changqing, add water to decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.11-1.13 (60°C), sp...

Embodiment 3

[0106] Embodiment 3 in vivo experiments

[0107] The low-dose group (i.e. 10 times the dose that the patient takes every day), the high-dose group (i.e. 20 times the dose that the patient takes every day) and the control group of the non-administered group are used for animal experiments in vivo and observed for 1 month. , the results showed that: the compound preparation can significantly reduce the lesion size of endometriosis induced by surgery in rats, increase the content of CD4+ T cells in the spleen of rats, reduce the content of CD8+ T cells in the spleen, thereby increasing the CD4 / The CD8 ratio can enhance the body's cellular immunity and promote the apoptosis of ectopic endometrium; it also shows that it can inhibit the proliferation of cells in endometriosis lesions.

[0108] Table 1. is the change of CD4 / CD8 in the spleen of each group of EMs model rats ( ).

[0109]Table 2 shows the changes of cell proliferation in endometriosis lesions in EMs model rats ( ...

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Abstract

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine compound preparation for treating endometriosis and a preparation method thereof. Granules of the traditional Chinese medicine compound preparation for treating endometriosis are made from extracts of medicinal materials: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Astragali Preparata, Radix Salviae Miltiorrhizae, baked Hirudo, Radix Paeoniae Rubra, Radix Cynanchi Paniculati, Spina Gleditsiae, Herba Epimedii, roasted Semen Persicae, Eupolyphaga seu Steleophaga, vinegar-processed Rhizoma Cyperi, vinegar-processed Rhizoma Corydalis and Crinis Carbonisatus. Animal experimental results show that the size of a focus of surgery-induced endometriosis in rats can be significantly reduced, the content of CD4+T cells of rat spleen can be increased, the content of CD8+T cells in spleen can be decreased, CD4 / CD8 ratio is thus increased, body cell immunity is enhanced, and apoptosis of ectopic endometrium is accelerated; the preparation can also inhibit proliferation of cells in the focus of endometriosis; clinical experimental results show that the compound preparation can reduce ovarian endometrioma and treat endometriosis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound traditional Chinese medicine preparation for treating endometriosis and a preparation method thereof. Background technique [0002] The prior art discloses that when the endometrial tissue with growth function appears in other parts of the body other than the lining mucosa of the uterine cavity, it is called endometriosis (endometriosis, EMs, referred to as endometriosis), and the invasion of the ovary is the most common. Common, also known as ovarian endometrioid cyst, accounts for about 80%, and its main manifestations are progressively aggravated dysmenorrhea and persistent lower abdominal pain, menstrual disorders, and infertility. It is a frequently-occurring and difficult disease in the field of gynecology. The pathological features of endometriosis are periodic hemorrhage of ectopic endometrium, accompanied by hyperplasia and adhesion of surrounding fi...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P15/00A61K35/62A61K35/64
Inventor 归绥琪朱芝玲王莉金志兴刘芳张先霞刘苡萱左治闵淑云
Owner THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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