Lenalidomide intermediate preparation method

A compound and better technology, applied in the field of synthesis of chemical drugs, can solve problems such as large environmental impact, difficulty in labor protection for experimenters, and difficulty in environmentally sound treatment
CN105523939AActive Publication Date: 2016-04-27SHANGHAI TIANCI BIOLOGICAL VALLEY BIOLOGICAL ENG
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
SHANGHAI TIANCI BIOLOGICAL VALLEY BIOLOGICAL ENG
Publication Date
2016-04-27

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Abstract

The present invention provides a lenalidomide intermediate preparation method, namely a preparation process of important intermediate 2-bromomethyl-3-nitro-methyl benzoate of 3-(4-amino-1-oxo-1,3-dihydro- 2H- isoindolyl-2-yl) piperidine-2,6-dione (namely lenalidomide).
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Description

technical field

[0001] The present invention relates to the field of synthesis of chemical drugs, in particular to a 3-(4-amino-1-oxo-1,3-dihydro-2H-isozainden-2-yl)piperidine-2, The preparation process of the important intermediate 2-bromomethyl-3-nitrobenzoate methyl ester (compound of formula I) of 6-diketone (lenalidomide). Background technique

[0002] Multiple myeloma (Multiplemgeloma, MM) is a refractory malignant B-cell disease, in patients with bone marrow malignant cells continue to proliferate, making normal cells unable to function. Myelodysplastic syndrome (myelodysplastic syndrome, MDS) is a clonal hematopoietic neoplasm. Myelodysplastic syndrome occurs when blood cells in the bone marrow are always in the immature stage and cannot perform their necessary functions. The bone marrow is full of these immature cells. Inhibits the development of normal cells. Chemotherapy for MM and MDS began in the 1960s. In the following 30 years, melphalan combined with predni...

Claims

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