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Nateglinide tablet and method for preparing nateglinide tablet through direct compression method

A technology of glinide tablets and nateglinide, applied in the field of medicine, can solve the problems of splinter, sticking, hemp and the like, and achieve the effect of clean production process and simple operation

Inactive Publication Date: 2016-05-04
ANHUI GLOBAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a kind of nateglinide tablet, which solves the problems of traditional nateglinide tablet fragments, hemp tablets, sticking and punching, etc.

Method used

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  • Nateglinide tablet and method for preparing nateglinide tablet through direct compression method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Each 1000 tablets of nateglinide contains:

[0026] Nateglinide 30g;

[0027] Anhydrous lactose 25g;

[0028] Pregelatinized starch 20g;

[0029] Carboxymethyl starch sodium 10g;

[0030] Hypromellose 25g;

[0031] Magnesium stearate 1g;

[0032] Micronized silica gel 3g.

[0033] Its preparation method comprises the following steps:

[0034] (1) Weighing of raw materials: Weigh 30g of nateglinide, 25g of anhydrous lactose, 20g of pregelatinized starch, 25g of hydroxypropyl cellulose, 10g of sodium carboxymethyl starch, 3g of micropowdered silica gel and stearin in a clean environment of grade D Magnesium acid 1g;

[0035] (2) Sieving: all the raw materials taken by weighing are passed through a 40 mesh sieve respectively, for subsequent use;

[0036] (3) Mixing: add the sieved nateglinide, anhydrous lactose, pregelatinized starch, hypromellose, sodium starch glycolate and micropowder silica gel into the mixer, and mix thoroughly;

[0037] (4) Total blending: i...

Embodiment 2

[0043] Each 1000 tablets of nateglinide contains:

[0044] Nateglinide 30g;

[0045] Anhydrous lactose 25g;

[0046] Microcrystalline cellulose 20g;

[0047] Carboxymethyl starch sodium 20g;

[0048] Hypromellose 15g;

[0049] Magnesium stearate 1g;

[0050] Micronized silica gel 3g.

[0051] Its preparation method comprises the following steps:

[0052] (1) Weighing of raw materials: Weigh 30g of nateglinide, 25g of anhydrous lactose, 20g of microcrystalline cellulose, 15g of hydroxypropyl cellulose, 20g of sodium carboxymethyl starch, 3g of micropowder silica gel and stearin in a clean environment of grade D Magnesium acid 1g;

[0053] (2) Sieving: all the raw materials taken by weighing are passed through a 40 mesh sieve respectively, for subsequent use;

[0054] (3) Mixing: add the sieved nateglinide, anhydrous lactose, pregelatinized starch, hypromellose, sodium starch glycolate and micropowder silica gel into the mixer, and mix thoroughly;

[0055] (4) Total ble...

Embodiment 3

[0061] Each 1000 tablets of nateglinide contains:

[0062] Nateglinide 30g;

[0063] Anhydrous lactose 25g;

[0064] Microcrystalline cellulose 10g;

[0065] Pregelatinized starch 10g;

[0066] Povidone K905g;

[0067] Carboxymethyl starch sodium 25g;

[0068] Hypromellose 10g;

[0069] Magnesium stearate 1g;

[0070] Micronized silica gel 3g.

[0071] Its preparation method comprises the following steps:

[0072] (1) Weighing of raw materials: Weigh 30g of nateglinide, 25g of anhydrous lactose, 10g of microcrystalline cellulose, 10g of pregelatinized starch, 5g of povidone K905g, 10g of hydroxypropyl cellulose, Sodium starch glycolate 25g, micropowder silica gel 3g and magnesium stearate 1g;

[0073] (2) Sieving: all the raw materials taken by weighing are passed through a 40 mesh sieve respectively, for subsequent use;

[0074] (3) Mixing: add the sieved nateglinide, anhydrous lactose, pregelatinized starch, hypromellose, sodium starch glycolate and micropowder sil...

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Abstract

The invention discloses a nateglinide tablet and a method for preparing the nateglinide tablet through a direct compression method, wherein each one thousand of nateglinide tablets are prepared from 30g of nateglinide, 45g of diluent, 35g of disintegrating agent, 1g of lubricating agent and 3g of flow aid, the preparation method for preparing the nateglinide tablet through direct compression by using a compressible auxiliary material comprises a process of weighing and matching, screening, mixing, tabletting, inner packing and packing under the D level condition, the nateglinide tablet and the method, provided by the invention solve the problems of cracking tablet, rough tablet, sticking and the like of a nateglinide tablet prepared through a traditional wet method.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a nateglinide tablet, and also relates to a method for preparing the nateglinide tablet by a direct tableting method. technical background [0002] Nateglinide is a derivative of D-phenylalanine. It mainly has two crystal forms, B-type and H-type. There are certain differences in the physical properties of the two crystal forms. The final product is H-type crystal. The drug causes Ca 2+ influx, intracellular Ca 2+ The concentration increases, thereby stimulating the secretion of insulin. The drug was first developed by the Swiss company Basel and put on the market in 1999. As a representative of a new generation of hypoglycemic drugs with an amino acid structure, it is not only the first insulin-secreting amino acid derivative for the treatment of type 2 diabetes, but also the only non-sulfonylurea insulin secretagogue with an amino acid structure. Compared with other oral...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/198A61P3/10
CPCA61K9/2059A61K9/2095A61K31/198
Inventor 王祥朱兆友
Owner ANHUI GLOBAL PHARM CO LTD
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