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Highly stable Radix Astragali injection and preparation method thereof

An astragalus injection and a high-stability technology are applied in the field of high-stability astragalus injection and its preparation, and can solve the problems of reduced curative effect, reduced saponins and flavonoids of active ingredients, and that traditional Chinese medicine preparations cannot achieve the synergistic effect of active ingredients, and the like, achieve the effect of avoided losses

Active Publication Date: 2016-05-11
JIANGSU JIUXU PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After adsorption and removal of impurities by macroporous adsorption resin, although the turbidity problem during the storage of Astragalus injection can be solved, the active ingredients saponins and flavonoids have dropped significantly, and the traditional Chinese medicine preparations produced by this process cannot achieve the synergy of the two types of active ingredients. effect, resulting in a reduction in efficacy

Method used

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  • Highly stable Radix Astragali injection and preparation method thereof

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Effect test

Embodiment 1

[0038] The present embodiment provides a kind of Radix Astragali injection, and its preparation method comprises the following steps:

[0039] (1) Take 2000g of astragalus, add water to decoct 3 times, combine the decoction, and concentrate the filtrate to 1-2g of the original medicinal material per 1ml.

[0040] (2) Precipitate with ethanol for 2 times, the ethanol content in the solution is 75% for the first time, and 85% for the second time, each time it is placed in cold storage, and the ethanol is recovered and concentrated to 10g of the original medicinal material per 1ml.

[0041] (3) Dilute with water for injection to 0.75-1g of the original medicinal material per 1ml, store in cold storage for 12 hours, filter, concentrate the filtrate to 5-6g of the original medicinal material per 1ml, and let it cool to obtain alcohol precipitation.

[0042] (4) Adjust the pH value of the alcohol precipitation solution to 1.5 with 20% hydrochloric acid solution, refrigerate, filter,...

Embodiment 2

[0046] This embodiment provides a kind of Radix Astragali Injection, compared with Embodiment 1, the difference is only: in the step (4) in this embodiment, use 15% hydrochloric acid solution and 15% sodium hydroxide solution to adjust the pH value respectively , control the pH value to 1 during the acid precipitation process.

Embodiment 3

[0048]This embodiment provides a kind of Radix Astragali Injection, compared with Embodiment 1, the only difference is that in step (4) in this embodiment, use 30% hydrochloric acid solution and 30% sodium hydroxide solution to adjust the pH value respectively , Control the pH value to 2 during the acid precipitation process.

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Abstract

The invention relates to the field of medicinal preparations, and concretely relates to a Radix Astragali injection and a preparation method thereof. The method comprises the following steps: carrying out water extraction and alcohol precipitation on Radix Astragali, carrying out acid precipitation treatment on the obtained alcohol precipitated liquid, adjusting the pH value to 7-8, preferably 7.5, by using an alkali, heating the obtained solution until boiling, refrigerating and disposing the boiled solution, and filtering the disposed solution to obtain the Radix Astragali injection. The above simple alcohol precipitated liquid pH value adjusting step is carried out to remove acidic impurities, and heat treatment, refrigeration and filtration are carried out to remove heat-insoluble impurities and ensure maximal reservation of effective components in the Radix Astragali. The preparation method solves the turbidity problem in the storage process of the Radix Astragali injection, avoids loss of the content of active actives, and maximally reserves the content of saponins and flavonoids, and especially the content of formononetin in the flavonoids.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a highly stable astragalus injection and a preparation method thereof. Background technique [0002] Astragalus is the root of the leguminous herb Astragalus mongolica and Astragalus membranaceus. Pharmacological studies have confirmed that Astragalus has the effects of strengthening the heart and expanding blood vessels, and Astragalus can improve cardiac systolic function while improving cardiac diastolic function, eliminating heart failure. In addition, it has a protective effect on the myocardium, which can protect the myocardium infected with ischemia and hypoxia, ischemia-reperfusion and virus, and can improve the electrical activity of cardiomyocytes, and has anti-arteriosclerosis and other effects. Astragalus extract is a Chinese herbal medicine that has the effects of nourishing qi and nourishing energy, strengthening the body and eliminating path...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K36/481
CPCA61K9/0019A61K9/08A61K36/481A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 高山李宏毛黎静张威范玲玲
Owner JIANGSU JIUXU PHARMA
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