Blood clotting time test analysis method

A blood coagulation time, test and analysis technology, which is applied in the field of thrombin time test and blood coagulation time test and analysis, can solve the problems of unsatisfactory monitoring accuracy, high value of detection equipment, and complicated detection equipment, so as to reduce the test cost and threshold, test The effect of convenient process and simple hardware and software

Inactive Publication Date: 2016-05-11
SHANGHAI UPPER BIO TECH PHARMA
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Problems solved by technology

[0005] For the detection of coagulation time in the prior art, the method of detecting the change of the optical properties (degree of light transmission) of the mixture of plasma and reagents, or the method of changing the magnetic properties, the above two methods for the detection ...

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  • Blood clotting time test analysis method

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Embodiment Construction

[0030] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0031] The principle of the present invention is that whole blood (including blood cells, platelets, and plasma) of the human body can flow in the capillary of a special disposable test piece. The blood coagulates under the action of the prefabricated dry coagulation activator in the test piece, and when the coagulation process is completed, the capillary microflow will stop. The coagulation time is the time from the beginning of blood contact with the reagent to the cessation of blood microflow. A conductive wire is plated in the capillary to measure the change of impedance with time when the fluid passes through the microfluidic channel. Furthermore, the coagulation time can be accurately determined according to the change of impedance with time. This is obtained by following the time profile of the impedance change. The PT reagent is used...

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Abstract

The invention relates to a blood clotting time test analysis method, especially relates to thrombin time test, and belongs to the technical field of blood clotting test analysis. The blood clotting time test analysis method is characterized in that a test piece (22) is provided with a blood sample accommodating cavity, a reagent accommodating cavity and a capillary channel (3) coated with a conductive layer (5); and the blood sample accommodating cavity, the reagent accommodating cavity and the capillary channel (3) coated with the conductive layer (5) are sequentially interconnected, a mixed liquid obtained after mixing a blood sample with a reagent flows to the capillary channel (3), the resistance of the conductive layer (5) changes with the flow of the mixed liquid, and the resistance changing stop time point is obtained to measure the time required by blood clotting. The method has the advantages of ingenious design, great improvement of the visual degree of a measurement result, great reduction of requirements of a test device, reduction of the test cost and threshold, convenience for use in outpatient departments and below county level small medical units, and convenience for gradual promotion of use in patients' homes.

Description

technical field [0001] The invention relates to a blood coagulation time test and analysis method, in particular to a thrombin time test. The invention belongs to the technical field of blood coagulation test analysis. Background technique [0002] The process of blood coagulation, referred to as coagulation, is the process of blood changing from a flowing state to a gel state, and it is an important part of the hemostatic function. The coagulation process is a process in which a series of coagulation factors are successively enzymatically activated (commonly known as endogenous and extrinsic coagulation pathways in academia), which produces thrombin protein and promotes fibrinogen to form fibrous thrombus clots. Clinically commonly used test methods include activated partial thromboplastin time (APTT) and prothrombin time (PT) and some other parameters for the prevention and cure of diseases such as thrombosis or fibrinolysis. PT is one of the four routine blood coagulati...

Claims

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Application Information

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IPC IPC(8): G01N33/86
CPCG01N33/86
Inventor 乔金·R·吴马里奥·莫雷诺
Owner SHANGHAI UPPER BIO TECH PHARMA
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