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A hyaluronic acid medical dressing

A hyaluronic acid and medical technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of short use time, serious waste, and long use cycle

Active Publication Date: 2019-01-22
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It is not difficult to find that this product has major shortcomings: the use time of a single product is too short each time, and the waste is serious; and the use cycle (treatment) is too long (two weeks to one month), and the operation and application are quite inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0023] Preparation of permanent hydrophobic airgel

[0024] With 1 liter of sodium water glass solution (containing 7% by weight of SiO2 and Na2O: SiO2 is 1: 3.3) and 0.5 liters of acidic ion exchange resin (the copolymer of styrene-divinylbenzene with sulfonic acid groups, commercially available under the tradename Duolite C20) were stirred together until the pH of the aqueous solution was 2.3. Then, the ion exchange resin was filtered off and the aqueous solution was adjusted to pH 5.0 using 1 molar NaOH solution. Then, the resulting gel was aged at 85° C. for 3 hours and the water was subsequently replaced with acetone, using 3 liters of acetone. The acetone-containing gel was then silylated with trimethylchlorosilane (5% by weight trimethylchlorosilane / gram wet gel). The gel was dried in air (3 hours at 40°C, then 2 hours at 50°C and 12 hours at 150°C).

[0025] The resulting transparent airgel had a density of 0.15 g / cm3, a specific surface area according to BET of 480...

Embodiment B

[0027] Preparation of Hydrophilic Airgel

[0028] The permanent hydrophobic airgel prepared in Example 1 was pyrolyzed in a tube furnace at 600 °C for 1 hour in a gentle air flow. The obtained transparent airgel had a density of 0.18 g / cm3, a specific surface area according to BET of 450 m2 / g, and it was hydrophilic.

[0029] Example of use:

[0030] In the usage examples, the hydrophilic and hydrophobic aerogels obtained according to the preparation methods of Examples A and B were used.

Embodiment 1

[0032] The composition is as follows:

[0033] Application (face) film material: non-woven fabric or silk or pectin fiber cloth;

[0034] Hyaluronic acid solution (original) solution: an aqueous solution of sodium hyaluronate, which also contains sodium alginate, glycerin, and preservatives. The contents in their solutions are: sodium hyaluronate 1mg / ml~2mg / ml, sodium alginate 5mg / ml~20mg / ml, glycerin 10mg / ml~300mg / ml, (optional) preservative 0mg / ml~5mg / ml ml, the balance is water (the total amount of supplement (solution) is / 1ml), the pH value is 6-7;

[0035] Aerogels prepared based on inorganic materials: hydrophilic aerogels and hydrophobic aerogels obtained by the preparation methods of Examples A and B, the ratio of hydrophilic aerogels and hydrophobic aerogels is 1:2-3 ;

[0036] The weight ratio of the above-mentioned airgel and the above-mentioned hyaluronic acid stock solution is 1:3-5.

[0037] The above-mentioned hyaluronic acid solution (original) solution is ...

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Abstract

The invention discloses a medical hyaluronic acid dressing with improved performances. The medical hyaluronic acid dressing comprises a dressing film material, a hyaluronic acid solution (or original fluid), hydrophilic aerogel, hydrophobic aerogel and a packing material, and the hydrophilic aerogel and the hydrophobic aerogel are prepared based on inorganic materials. The hyaluronic acid solution (or original fluid) is adsorbed by the aerogels. The medical hyaluronic acid dressing has the advantages of high efficiency, long-acting effects, long duration in single-time application or action, excellent clinical effects, short treatment course or use cycle and great convenience in operation and application.

Description

technical field [0001] The invention relates to a medical dressing. Specifically, it relates to a hyaluronic acid medical dressing with excellent performance. Background technique [0002] Hyaluronic acid (Hyaluronic acid, HA) is a chain polymer adhesive formed by repeated alternating links of D-glucuronic acid and N-acetylglucosamine with B-1, 3 and B-1, 4 glycosidic bonds. Polysaccharides, one of the glycosaminoglycans, are acidic mucopolysaccharides, widely distributed in various parts of the human body, and the skin also contains a large amount of hyaluronic acid. [0003] In the body, hyaluronic acid is a multifunctional matrix that exhibits a variety of important physiological functions, such as regulating proteins, assisting the diffusion and transport of water and electrolytes, lubricating joints, regulating the permeability of blood vessel walls, and promoting wound healing, etc. Wait. More importantly, hyaluronic acid has a special water-retaining effect, and is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42
CPCA61L15/18A61L15/28A61L15/42C08L5/08
Inventor 王晶汪亚萍戴菊英
Owner JIANGSU SEMPOLL PHARMA