Antibacterial and hemostasia compound sponge and preparation method thereof

A composite sponge and nanocomposite material technology, applied in pharmaceutical formulations, surgical adhesives, applications, etc., can solve the problems of poor toughness and insignificant hemostatic effect, and achieve the prevention of wound infection, excellent antibacterial properties and thermal stability, inhibiting The effect of bacterial growth

Inactive Publication Date: 2016-06-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a preparation method of an antibacterial and hemostatic composite sponge. Carboxymethyl chitosan quaternary ammonium salt / organic montmorillonite nanocomposite material and sodium alginate are cross-linked to obtain a composite sponge with improved comprehensive performance, which overcomes the Simple chitosan hemostatic material has the problems of poor toughness and insignificant hemostatic effect

Method used

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  • Antibacterial and hemostasia compound sponge and preparation method thereof
  • Antibacterial and hemostasia compound sponge and preparation method thereof
  • Antibacterial and hemostasia compound sponge and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] 0.5g carboxymethyl chitosan quaternary ammonium salt / organic montmorillonite nanocomposite material is dissolved in deionized water and is made into the solution of 50mg / mL, wherein the weight average molecular weight of used carboxymethyl chitosan quaternary ammonium salt is 2.5×10 5 , the degree of substitution of carboxymethyl is 40%, and the degree of substitution of quaternary ammonium salt is 60%. Dissolve 0.1g of sodium alginate in deionized water to make a 10mg / mL solution. Polysaccharide quaternary ammonium salt / organic montmorillonite nanocomposite solution and sodium alginate solution are evenly mixed and then transferred to the mold. The weight ratio is about 5:1, soaked in 1wt% calcium chloride solution, reacted for 0.5h and freeze-dried to obtain the composite sponge.

Embodiment 2

[0031] 0.4g carboxymethyl chitosan quaternary ammonium salt / organic montmorillonite nanocomposite material is dissolved in deionized water and is made into the solution of 40mg / mL, wherein the weight average molecular weight of used carboxymethyl chitosan quaternary ammonium salt is 4.0×10 5 , the degree of substitution of carboxymethyl is 50%, the degree of substitution of quaternary ammonium salt is 65%, 0.2g of sodium alginate is dissolved in deionized water to make a solution of 20mg / mL, under the condition of stirring, the carboxymethyl shell Polysaccharide quaternary ammonium salt / organic montmorillonite nanocomposite solution and sodium alginate solution are evenly mixed and then transferred to the mold. The weight ratio is about 2:1, soaked in 2wt% calcium chloride solution, reacted for 1.0h and freeze-dried to obtain the composite sponge.

Embodiment 3

[0033] 0.3g carboxymethyl chitosan quaternary ammonium salt / organic montmorillonite nanocomposite material is dissolved in deionized water and is made into the solution of 30mg / mL, wherein the weight average molecular weight of used carboxymethyl chitosan quaternary ammonium salt is 8.0×10 5 , the degree of substitution of carboxymethyl is 60%, the degree of substitution of quaternary ammonium salt is 75%, 0.3g of sodium alginate is dissolved in deionized water to make a solution of 30mg / mL, under the condition of stirring, the carboxymethyl shell Polysaccharide quaternary ammonium salt / organic montmorillonite nanocomposite solution and sodium alginate solution are evenly mixed and then transferred to the mold. The weight ratio is about 1:1, soaked in 3wt% calcium chloride solution, reacted for 2 hours and freeze-dried to obtain the composite sponge.

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Abstract

The invention discloses an antibacterial and hemostasia compound sponge and a preparation method thereof. The method includes the steps of using carboxymethyl chitosan quaternary ammonium salt/organic montmorillonite nanocomposite and sodium alginate as raw materials, and conducting blending, ion crosslinking and freeze-drying to finally obtain the compound sponge. The antibacterial and hemostasia compound sponge of the three-dimensional network structure is obtained by controlling the concentration of carboxymethyl chitosan quaternary ammonium salt/organic montmorillonite and the concentration and crosslinking time of sodium alginate. The operation in the process is simple, organic crosslinking agents are avoided, and the preparation method is green and environmentally friendly and completely conforms to the requirement for 'green chemistry'. The compound sponge prepared through the method has good physical strength and antibacterial performance, and has the advantages of being high in water absorption, capable of achieving hemostasis and promoting wound healing and the like. Therefore, the antibacterial and hemostasia compound sponge has great application prospects in the field of biomechanical materials.

Description

technical field [0001] The invention belongs to the field of nanotechnology, and in particular relates to an antibacterial hemostatic sponge and a preparation method thereof. Background technique [0002] Hemostatic materials are of great significance to quickly and effectively control bleeding, reduce trauma, and prevent bacterial infection in the first place. There are many kinds of traditional hemostatic materials, but they all have certain shortcomings, such as loose structure, poor adhesion to wound tissue, relatively long hemostasis time, which may cause secondary bleeding, prone to viral infection and short shelf life, etc. . As a new generation of hemostatic materials, chitosan, which is non-toxic, non-irritating and naturally degradable, has high development value. [0003] Chitosan is the only positively charged alkaline polysaccharide in nature, which has many functions such as hemostasis, antibacterial, anticancer, and promotion of wound healing. Chitosan can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61L26/00
CPCA61L24/0073A61L24/0015A61L24/0036A61L24/08A61L26/0023A61L26/0066A61L26/0085A61L2300/232A61L2300/404A61L2400/04A61L2400/12
Inventor 王小英叶伟杰孙润仓
Owner SOUTH CHINA UNIV OF TECH
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