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Fungus strain with Alzheimer's disease treating function and application of fungus strain

A technology for Alzheimer's disease and strains, applied in the field of microorganisms, can solve the problems of difficult to obtain pure optically active compounds, lack of plant resources, high cost, etc., to meet the needs of drugs, protect plant resources, and reduce medical expenses. Effect

Active Publication Date: 2016-06-08
陕西仁达康健医药生物科技有限公司
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Problems solved by technology

[0005] The purpose of the present invention is to provide a fungal strain with the function of treating Alzheimer's disease, to solve the bottleneck of plant resource shortage in obtaining huperzine A from plant extraction; and the chemical synthesis steps are cumbersome and expensive, and it is difficult to obtain pure optical activity The compound problem

Method used

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  • Fungus strain with Alzheimer's disease treating function and application of fungus strain
  • Fungus strain with Alzheimer's disease treating function and application of fungus strain
  • Fungus strain with Alzheimer's disease treating function and application of fungus strain

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Embodiment Construction

[0021] The present invention will be described in detail below in conjunction with the drawings and specific embodiments.

[0022] The present invention is a fungal strain with the function of treating Alzheimer's disease. The strain is obtained from the endophytic fungi of Huperziaserrata (Huperziaserrata, Huperzia), belonging to the Trichoderma harzianum species ( Trichodermaharzianum) NSW-V strain has genetic stability after 15 generations in the laboratory, and its amino sequence is shown in SEQ ID NO:1.

[0023] This strain has been preserved in the China Common Microbial Strain Collection, the preservation unit designated by the State Intellectual Property Office.

[0024] Biological material deposit information:

[0025] Name: Trichodermaharzianum NSW-V strain

[0026] Deposit number: CGMCCNo.12076

[0027] Preservation unit: General Microbiology Center (CGMCC) of China Microbial Culture Collection Management Committee

[0028] Preservation time: January 15, 2016

[0029] Address: ...

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Abstract

The invention discloses a fungus strain with an Alzheimer's disease treating function and application of the fungus strain. The fungus strain is separated from wild huperzia serrata endophytic fungi and belongs to the Trichoderma harzianum NSW-V strain, the fungus strain has genetic stability after 15 generation passages in a lab, and the amino sequence of the fungus strain is as shown in SEQ ID NO. 1. The fungus strain with the Alzheimer's disease treating function has the advantages that the fungus strain serving as the biological strain for treating the Alzheimer's disease transfers the excellent efficient expression genes for producing huperzine a into strains of other modes, more excellent properties are obtained through gene modification, and the strain can be further optimized through mutation breeding; the researches of the fungus strain are greatly significant to the biological synthesizing and industrial production of the huperzine a, plant resource protection, satisfying of the clinical front-line medicine use requirements, and lowering of the medical cost for treating the Alzheimer's disease.

Description

Technical field [0001] The present invention belongs to the technical field of microorganisms, and specifically relates to a fungal strain with the function of treating Alzheimer's disease. The present invention also relates to the application of the fungal strain. Background technique [0002] At present, acetylcholinesterase inhibitor drugs are in a leading position in the Alzheimer's disease drug market. Huperzine A is a new type of lycopodium monoalkaloid isolated from the folk herbal medicine Huperzia serrata. It is a potent and reversible cholinesterase inhibitor with multi-target effects and has a positive effect on acetylcholinesterase. The inhibitory effect is 3 times that of physostigmine and 30 times that of galantamine, and the peripheral side effects are low. It is one of the clinically preferred drugs for the treatment of Alzheimer's disease. [0003] The development of drugs derived from natural plants has a long history and is full of vitality. Plant extraction is ...

Claims

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Application Information

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IPC IPC(8): C12N1/14A61K36/06A61P25/28C12R1/885
CPCA61K36/06C12N1/14C12R2001/885C12N1/145
Inventor 韩文霞李伟泽韩忠文张寒孙静李妮王琳周永强
Owner 陕西仁达康健医药生物科技有限公司
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