Dark-field illumination acoustic resolution photoacoustic microscopic device

Abstract

The invention provides a dark-field illumination acoustic resolution photoacoustic microscopic device, and belongs to the technical field of medical imaging. A photoacoustic coupling module of the device is used for converging pulse laser output by a light source and a transmission module, a control module is used for taking electric pulses output by the light source and the transmission module as synchronous signals to control a three-dimensional displacement module, the photoacoustic coupling module is driven to carry out two-dimension grid scanning to an imaging target through outputting pulse laser, and a rebuilding module is used for rebuilding a three-dimensional image of the imaging target in dependence on photoacoustic signals acquired by an ultrasonic signal transmit-receive module. According to the invention, the light focusing degree of the pulse laser is increased through the photoacoustic coupling module, the energy density of pulsed light being incident on the tissue surface is increased, and therefore the demand on single pulse energy can be reduced, furthermore the flexibility is improved, and the cost is reduced; because the demand on single pulse energy is reduced, the output frequency of laser pulses can be increased, and the imaging speed is increased.

Description

technical field [0001] The invention relates to a dark-field illumination acoustic resolution photoacoustic microscope device, which belongs to the technical field of medical imaging. Background technique [0002] Acoustic resolution photoacoustic microscopy is an important branch of photoacoustic imaging technology applications. Images obtained through it can achieve excellent optical absorption contrast while achieving the depth and resolution of ultrasound imaging. The principle of acoustic resolution photoacoustic microscopy is to use ultrashort pulse laser to irradiate endogenous or exogenous absorbers in tissues to produce thermoelastic effect when absorbing light energy, thereby exciting ultrasonic waves, that is, photoacoustic signals. By detecting the photoacoustic signal excited by a laser pulse, the depth information of the image can be obtained by distinguishing the time interval between the photoacoustic signals, and then the three-dimensional image information...

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that the existing dark-field illumination acoustic resolution photoacoustic microscopy technology has a low light focusing degree, so that it cannot meet the requirement of a large light energy density at the same time, the present invention further proposes a dark-field illumination acoustic resolution The photoacoustic microscopy device specifically includes the following technical solutions:

Images