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Rhizoma corydalis pain killer and preparation method thereof

A technology of Yuanhu Zhitong Tablets and Hu Zhitong Tablets, which is applied in the direction of non-central analgesics, pharmaceutical formulas, medical preparations with non-active ingredients, etc. It can solve the problems of affecting drug absorption, destroying active ingredients, affecting the quality and efficacy of preparations, etc. question

Inactive Publication Date: 2016-06-15
韩志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the extraction process is unreasonable and unscientific, it will inevitably cause damage and loss of active ingredients, thereby affecting the quality and curative effect of the preparation
In addition, the disintegration time of the existing Yuanhu Zhitong Tablets is relatively long, especially after long-term storage, there is a phenomenon that exceeds the pharmacopoeia standard, and too long disintegration time will seriously affect the absorption of drugs
[0004] With the continuous improvement of clinical requirements on the quality and effect of drugs and the continuous development of pharmaceutical technology, this technology can no longer meet the current needs. There is an urgent need for a preparation technology with more complete extraction of active ingredients and higher content to better play the role. The Medicinal Value of the Classical Prescription of Huzhitong Tablets

Method used

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  • Rhizoma corydalis pain killer and preparation method thereof
  • Rhizoma corydalis pain killer and preparation method thereof
  • Rhizoma corydalis pain killer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Vinegar Corydalis 445g Angelica dahurica 223g

[0106] Crospovidone 10g Sodium Carboxymethyl Starch 5g

[0107] Croscarmellose Sodium 5g.

[0108] The preparation method is:

[0109] 1 / 2 amount of vinegar corydalis is superfinely pulverized to obtain superfine powder; during the superfine pulverization process, 100g of dry ice is sprayed as a coolant; after superfine pulverization, 90-95% of the micropowder particle size is 3-6 microns; The remaining 1 / 2 amount of vinegar corydalis is ultrafinely pulverized to 5 microns, and the ultrafine powder is placed in CO 2 Soak in the extraction kettle for 3 hours, control the pressure in the extraction kettle to 25MPa; separate the soaked ultrafine powder in the separation kettle, control the separation pressure value in the separation kettle to 6MPa, heat to 40°C, keep for 5 hours, CO 2 The flow rate is maintained at 30Kg / h; the separated extract is dried to obtain extract A; the Angelica dahurica is soaked in 8 times the am...

Embodiment 2

[0111] Vinegar Corydalis 250g Angelica dahurica 300g

[0112] Crospovidone 6g Sodium Carboxymethyl Starch 7g

[0113] Croscarmellose sodium 3g;

[0114] 1 / 2 amount of vinegar corydalis is superfinely pulverized to obtain superfine powder; during the superfine pulverization process, 100g of dry ice is sprayed as a coolant; after superfine pulverization, 90-95% of the micropowder particle size is 3-6 microns; The remaining 1 / 2 amount of vinegar corydalis is ultrafinely pulverized to 5 microns, and the ultrafine powder is placed in CO 2 Soak in the extraction kettle for 3 hours, control the pressure in the extraction kettle to 25MPa; separate the soaked ultrafine powder in the separation kettle, control the separation pressure value in the separation kettle to 6MPa, heat to 40°C, keep for 5 hours, CO 2 The flow rate is maintained at 30Kg / h; the separated extract is dried to obtain extract A; the Angelica dahurica is soaked in 8 times the amount of water for 30 minutes, and 40g ...

Embodiment 3

[0116] Vinegar Corydalis 640g Angelica dahurica 130g

[0117] Crospovidone 14g Sodium Carboxymethyl Starch 3g

[0118] Croscarmellose sodium 7g;

[0119] 1 / 2 amount of vinegar corydalis is superfinely pulverized to obtain superfine powder; during the superfine pulverization process, 100g of dry ice is sprayed as a coolant; after superfine pulverization, 90-95% of the micropowder particle size is 3-6 microns; The remaining 1 / 2 amount of vinegar corydalis is ultrafinely pulverized to 5 microns, and the ultrafine powder is placed in CO 2 Soak in the extraction kettle for 3 hours, control the pressure in the extraction kettle to 25MPa; separate the soaked ultrafine powder in the separation kettle, control the separation pressure value in the separation kettle to 6MPa, heat to 40°C, keep for 5 hours, CO 2 The flow rate is maintained at 30Kg / h; the separated extract is dried to obtain extract A; the Angelica dahurica is soaked in 8 times the amount of water for 30 minutes, and 40g...

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Abstract

The invention discloses Yuanhu Zhitong Tablet and a preparation method thereof. The Yuanhu Zhitong tablet is composed of vinegar Corydalis and Angelica dahurica; the preparation method of the Yuanhu Zhitong tablet of the present invention is to ultrafinely pulverize 1 / 2 amount of Corydalis Corydalis, extract the remaining Corydalis Corydalis with compound enzymes, and perform supercritical extraction of Angelica dahurica; The invention has the advantages of more complete extraction of active ingredients, higher content, fast drug dissolution rate, high bioavailability and good stability through the improved process.

Description

technical field [0001] The invention relates to a medicinal preparation in the field of medicine, in particular to Yuanhu Zhitong Tablet and a preparation method thereof. Background technique [0002] Yuanhu Zhitong Tablets are listed in the Chinese Pharmacopoeia. Prepared from Corydalis Corydalis and Angelica dahurica, it has the effects of regulating qi, promoting blood circulation and relieving pain. It is used for stomach pain, hypochondriac pain, headache and dysmenorrhea caused by qi stagnation and blood stasis. [0003] At present, the preparation process of Yuanhu Zhitong Tablets basically follows the traditional process method, and a part of Angelica dahurica is crushed into fine powder; the rest of Angelica dahurica is crushed into coarse powder with vinegar Corydalis for extraction. Due to the open type pulverization of ordinary pulverizers, there will be disadvantages such as large particle size during granulation, which will cause heavy metal pollution, slow dr...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/28A61K47/38A61K47/36A61K47/32A61P29/00A61P15/00A61K36/232
CPCA61K36/66A61K9/2027A61K9/2054A61K9/2059A61K9/28A61K36/232A61K2236/15A61K2236/19A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2236/53
Inventor 韩志强
Owner 韩志强
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