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Injectable and degradable thermo-sensitive hydrogel and preparation method thereof

A temperature-sensitive hydrogel and collagen technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and pharmaceutical sciences, etc., and can solve the problems that injectable hydrogels cannot be effectively degraded and the scope of application is limited. , to achieve the effect of expanding the scope of application and practical value

Inactive Publication Date: 2016-06-15
BIOTOWNTEK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide an injectable degradable thermosensitive hydrogel and its preparation method, aiming at solving the problem that the current injectable hydrogel cannot be effectively degraded in vivo. , which limits its application to the problem of

Method used

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  • Injectable and degradable thermo-sensitive hydrogel and preparation method thereof
  • Injectable and degradable thermo-sensitive hydrogel and preparation method thereof
  • Injectable and degradable thermo-sensitive hydrogel and preparation method thereof

Examples

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Embodiment 1

[0051] Example 1 Injectable degradable thermosensitive hydrogel based on PNIPAAm-sodium alginate

[0052] This example mainly combines the excellent characteristics of sodium alginate, and based on the temperature-sensitive hydrogel basic material PNIPAAm, through a series of reactions to prepare a temperature-sensitive injectable hydrogel material with degradable properties (see figure 1 ). Therefore, in this embodiment, as a material combined with PNIPAAm.

[0053] In this example, the specific preparation process for preparing an injectable degradable thermosensitive hydrogel based on PNIPAAm-sodium alginate is as follows: for example, 1 g, 2.5 g, 5 g or 10 g of sodium alginate, and 200 ml of deionized water are respectively Add it into the reaction flask, stir and dissolve with a magnetic stirrer, and then pass nitrogen gas for 15 minutes; then add NIPAAm monomer, such as 0.5g, 1g, 2g, 3g, 4g or 5g of NIPAAm monomer; then add appropriate amount of NIPAAm monomer The coup...

Embodiment 2

[0054] Example 2 Injectable degradable thermosensitive hydrogel based on PNIPAAm-chitosan

[0055] This embodiment mainly combines the excellent characteristics of chitosan, and based on the temperature-sensitive hydrogel basic material PNIPAAm, a temperature-sensitive injectable hydrogel material with degradable properties is prepared through a series of reactions (see figure 2 ). Therefore, in this example, chitosan and PNIPAAm were combined to prepare hydrogels.

[0056] In this example, the specific preparation process for preparing an injectable degradable thermosensitive hydrogel based on PNIPAAm-chitosan is as follows: first prepare 2.5% chitosan acetic acid solution, that is, weigh 2.5g chitosan, 2.0g Acetic acid is mixed uniformly in 95.5g deionized water, and chitosan is dissolved at room temperature, stand-by; Then add deionized water and above-mentioned 2.5% chitosan acetic acid solution according to the volume ratio is 20:1 or 15:1 or 10: 1 Mix well, for exampl...

Embodiment 3

[0057] Example 3 Injectable degradable thermosensitive hydrogel based on PNIPAAm-chitosan-collagen

[0058] This embodiment mainly combines the excellent properties of collagen, and based on the temperature-sensitive hydrogel basic material PNIPAAm, through a series of reactions to prepare a temperature-sensitive injectable hydrogel material with degradable properties (see image 3 ). This embodiment mainly includes three basic components, one is the hydrogel skeleton PNIPAAm, in addition, chitosan and type I rat tail collagen need to be added. The construction of PNIPAAm-chitosan-collagen hydrogel can further improve the bioaffinity and biodegradability of the hydrogel.

[0059] In the present embodiment, the concrete preparation process of the injectable and degradable thermosensitive hydrogel of preparation PNIPAAm-chitosan-collagen is: first prepare 2% chitosan hydrochloric acid solution, be about to dissolve 2g chitosan in 0.1 of 100ml mol / L hydrochloric acid, stirred u...

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Abstract

The invention discloses injectable and degradable thermo-sensitive hydrogel and a preparation method thereof. The injectable and degradable thermo-sensitive hydrogel is prepared from poly(N-isopropylacrylamide) and sodium alginate, chitosan, collagen, hyaluronic acid, methylcellulose or a polylactic acid-glycolic acid copolymer. A thermo-sensitive material is organically combined with a material with a degradation characteristic, the degradable thermo-sensitive hydrogel material can be formed, the problem that a current hydrogel material cannot be degraded in a body is solved, the application range of the hydrogel is greatly enlarged, and the practical value of the hydrogel is greatly increased.

Description

technical field [0001] The invention relates to the field of injectable hydrogels, in particular to an injectable degradable temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] In recent years, injectable hydrogel, as a new type of biomedical polymer material, has become one of the hot spots in the field of biomedicine. It mainly means that it is in a liquid state before injection, but after being injected into the human body, it turns into a gel state due to temperature changes. According to different gelation principles, injectable hydrogels can be divided into two categories, one is physically cross-linked hydrogels, and the other is chemically cross-linked hydrogels. Among them, physically cross-linked hydrogels include temperature-sensitive injectable hydrogels, pH-sensitive injectable hydrogels, and photosensitive hydrogels. Chemically crosslinked hydrogels can be further divided into injectable hydrogels based on enzyme-cat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/52A61L27/58A61L27/50A61K9/06A61K47/32A61K47/36A61K47/42A61K47/38C08J3/075C08F220/54C08F222/38
CPCA61L27/26A61K9/0024A61K9/06A61K47/32A61K47/36A61K47/38A61K47/42A61L27/52A61L27/58A61L2400/06C08F220/54C08J3/075C08F222/38C08L5/04C08L5/08C08L1/28C08L67/04C08L1/286C08L33/24
Inventor 陈光风史秀娟刘小青
Owner BIOTOWNTEK CO LTD
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