Traditional Chinese medicine composition for improving sleep and memory and preparation method of traditional Chinese medicine composition for improving sleep and memory
A technology to improve sleep and memory, which is applied in the field of medicine and health, can solve the problems of less dissolution of active ingredients and low bioavailability, and achieve the effects of prolonging sleep time, improving cognitive impairment, and reducing the number of mistakes
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Embodiment 1
[0051] Take 3kg of Codonopsis pilosula, 3kg of Poria cocos and 2kg of polygala respectively and pulverize them into coarse powder, add 30% ethanol to soak for 24 hours, and reflux extraction for 2-3 times. Combine the extracts, concentrate under reduced pressure to a raw concentration of 0.5g / ml, add 4 times 85-95% ethanol for alcohol precipitation to remove impurities, alcohol precipitation time is 12h, filter, centrifuge (3000r / min) for 15min, filter and discard Precipitate, concentrate until the crude drug concentration is 0.5g / ml, take the liquid and pass through the HPD-100 macroporous resin column for secondary purification, the loading volume is 4 times the volume of the resin column, and the loading flow rate is 3BV / h, with 6 Carbohydrate components were eluted with 1 times column volume of water 1BV / h, followed by 6 times column volume of 40% ethanol with 1BV / h to elute saponins components, combined eluents, dried to obtain mixed extracts, and then The mixed extract i...
Embodiment 2
[0053] Take 3kg of Codonopsis pilosula, 3kg of Poria cocos, and 2kg of polygala, and grind them into coarse powder, add 40% ethanol to soak for 24 hours, and reflux extraction twice. The amount of ethanol for each time is 12 times the total weight of the medicinal materials. solution, concentrated under reduced pressure to a raw concentration of 0.5g / ml, added 5 times of 85% ethanol for alcohol precipitation to remove impurities, alcohol precipitation time was 12h, filtered, centrifuged (2000r / min) for 20min, filtered to discard the precipitate, concentrated to The concentration of the crude drug is 0.5g / ml, and the medicinal solution is passed through a HPD-100 macroporous resin column for secondary purification. The loading volume is 4 times the volume of the resin column, and the loading flow rate is 4BV / h. Water eluted sugar components at 2BV / h, followed by 6 column volumes of 40% ethanol to elute saponin components at 2BV / h, combined eluents, dried to obtain mixed extracts...
Embodiment 3
[0055] Take 3kg of Codonopsis pilosula, 3kg of Poria cocos, and 2kg of polygala, and grind them into coarse powder, add 40% ethanol to soak for 24 hours, and reflux extraction for 3 times. The amount of ethanol for each time is 10 times the total weight of the medicinal materials. solution, concentrated under reduced pressure to a raw concentration of 0.5g / ml, added 4 times of 85% ethanol for alcohol precipitation to remove impurities, alcohol precipitation time was 18h, filtered, centrifuged (3000r / min) for 15min, filtered to discard the precipitate, concentrated to The concentration of the crude drug is 0.5g / ml, and the medicinal solution is passed through a HPD-100 macroporous resin column for secondary purification. The loading volume is 4 times the volume of the resin column, and the loading flow rate is 3BV / h. The sugar components were eluted with water at 1BV / h, and the saponin components were eluted with 5 times column volume of 60% ethanol at 1BV / h. The eluents were co...
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