Membrane-method pyrogen removing technology in pharmaceutical industry
A technology for the pharmaceutical industry and heat source, applied in chemical instruments and methods, multi-stage water treatment, osmotic/dialysis water/sewage treatment, etc., can solve the problems of low heat removal efficiency, unsuitable use of small doses of drugs, and difficulty in regeneration of adsorbents. , to achieve the effect of low production and operation costs
Inactive Publication Date: 2016-06-22
KUNSHAN DONGDA ZHIHUI TECH CONSULTANT
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Problems solved by technology
However, activated carbon will also absorb part of the liquid medicine, so it must be fed in excess when used, so small doses of medicines are not suitable for use
The efficiency of heat removal by adsorption is low and the regeneration of adsorbent is also difficult;
Method used
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Embodiment Construction
[0017] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
[0018] The membrane method heat source removal technology in the pharmaceutical industry of the specific embodiment of the present invention, it comprises steps:
[0019] a. The valve opens automatically after the heat source liquid reaches a certain volume in the storage tank;
[0020] b. The heat source feed liquid is pumped through the pipeline filter to three-stage parallel membrane filtration equipment, and each stage has three series-connected nine membrane module monomers for graded filtration. Three membrane module monomers in series The membrane pore sizes are 15nm, 8nm and 3nm respectively;
[0021] c. When...
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The invention discloses a membrane-method pyrogen removing technology in pharmaceutical industry. The technology comprises the steps that 1, a valve is automatically switched on after pyrogen material liquid reaches the certain volume in a storage tank; 2, the pyrogen material liquid is pumped to membrane filtration equipment composed of nine membrane component monomers for grading filtration, wherein three stages of the membrane component monomers are connected in parallel, three membrane component monomers which are connected in series are arranged in each stage, and the membrane hole diameters of every three membrane component monomers which are connected in series are 15 nm, 8 nm and 3 nm respectively; 3, when 50% of the flux remains, top washing is performed by adding pure water, and finally brown sticky concentrated liquid is drained; 4, the drained concentrated liquid enters an evaporating tank, moisture is removed, concentrated incineration treatment is performed on obtained colloid filter residues, and obtained filtered material liquid is clear, transparent and colorless aqueous liquid. According to the membrane-method pyrogen removing technology in the pharmaceutical industry, thermal destruction cannot be caused to the effective ingredients, and the production and operation cost is low.
Description
technical field [0001] The invention relates to the technical field of pharmacy and chemical industry, in particular to a process for removing heat source by membrane method in the pharmacy industry. Background technique [0002] Pyrogen, also known as endotoxin, is an association formed in aqueous solution, with a relative molecular weight of more than 500,000. It has heat resistance and chemical stability, and is not easy to be eliminated. If a small amount of heat source is injected into the human blood system, it will cause severe fever and even death. Therefore, in the pharmaceutical industry, it is very necessary to reduce the content of heat source in the liquid medicine as much as possible. Even more stringent, for example, the heat source qualified index control value of the large infusion solution of Shanghai Changzheng Pharmaceutical Factory is 0.25EU / ml. [0003] There are currently three types of heat removal methods: [0004] 1. Distillation produces depyroge...
Claims
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IPC IPC(8): C02F1/44
CPCC02F1/44C02F2301/066C02F2301/08
Inventor 不公告发明人
Owner KUNSHAN DONGDA ZHIHUI TECH CONSULTANT