Biomaterial having enhanced rubber properties through natural cross-linkage of collagen and hyaluronic acid, preparing method thereof, and using method thereof

A collagen and natural cross-linking technology, applied in cosmetic preparations, skin care preparations, medical preparations containing active ingredients, etc., can solve problems such as limitations, inability to achieve satisfactory dosage forms, and inability to provide manufacturing methods, etc. Achieve the effect of improving quality and reliability

Active Publication Date: 2016-06-22
SEWON CELLONTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is to say, the above-mentioned prior art adopts a simple mixing method of collagen and hyaluronic acid, and it is impossible to achieve a formulation that meets the purpose of use without using a chemically cross-linked substance
[0009] Because the above-mentioned prior art uses a cross-linking method of simple mixing, especially a cross-linking method using chemical substances, safety problems caused by residual substances, decomposed substances, or crosslinked substances cannot be ruled out.
In addition, the dosage forms that can be used are also limited to the dosage forms in the dry state, and it is not possible to provide a variety of methods in terms of fields of use and methods of use.
[0010] In general, the above-mentioned prior art cannot provide a simple and safe manufacturing method that meets the purpose of industrialization

Method used

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  • Biomaterial having enhanced rubber properties through natural cross-linkage of collagen and hyaluronic acid, preparing method thereof, and using method thereof
  • Biomaterial having enhanced rubber properties through natural cross-linkage of collagen and hyaluronic acid, preparing method thereof, and using method thereof
  • Biomaterial having enhanced rubber properties through natural cross-linkage of collagen and hyaluronic acid, preparing method thereof, and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Manufacturing method of natural cross-linked rubber dosage form material using collagen and hyaluronic acid: Syringe mixing

[0086] 1. Purpose: To confirm the dosage form conditions using collagen and hyaluronic acid.

[0087] 2. Method: 1% (w / v) concentration of collagen solution and hyaluronic acid solution were prepared using raw materials respectively. Mix each raw material at a ratio of 1:2 to 9:1 (collagen:hyaluronic acid). The solution filled in the injection device is connected with a connector, and the production state of the rubber dosage form is checked during bidirectional mixing. The hyaluronic acid used at this time has a molecular weight of 1,000Kda.

[0088] 3. Results: Under the condition that the concentration of each raw material is 1%, the natural cross-linked substance produced under the mixing condition of 2:1 to 7:1 is a substance with rubber properties. Among them, the ratio of 3:1 is the best condition. Under these conditions, a dosage form...

Embodiment 2

[0090] Manufacturing method of natural cross-linked rubber dosage form using collagen and hyaluronic acid: centrifugation

[0091] 1. Purpose: To confirm the manufacturing method required for the mass production of collagen and hyaluronic acid.

[0092] 2. Method: 1% (w / v) concentration of collagen solution and hyaluronic acid solution were prepared using raw materials respectively. Mix the ingredients in a ratio of 3:1 (collagen:hyaluronic acid). By shocking the solution by applying high energy during mixing, lumps will form. After removing the solution other than the above-mentioned lumps, the lumps are concentrated and sufficiently dehydrated by a centrifugation method, thereby producing a rubber dosage form substance.

Embodiment 3

[0094] Manufacturing method of natural cross-linked rubber dosage form using collagen and hyaluronic acid: Blender

[0095] 1. Purpose: To confirm the manufacturing method required for the mass production of collagen and hyaluronic acid.

[0096] 2. Method: Use a blender to mix collagen and hyaluronic acid at a ratio of 3:1 and layer them, then sieve to remove moisture and then use a blender to increase its flexibility. The steps of manufacturing the dosage form are shown in Fig. 11(a)(b)(c).

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Abstract

The present invention relates to a biomaterial having enhanced rubber properties through natural cross-linkage of collagen and hyaluronic acid, a preparing method thereof, and a using method thereof. To this end, the present invention is characterized in that a rubber type biomaterial is prepared by natural cross-linkage of collagen and hyaluronic acid at a ratio of 2:1 to 7:1. The present invention as described above creates a novel material exhibiting rubber properties by providing the conditions for natural cross-linkage rather than chemical or physical cross-linkage and mixing at the optimum ratio of collagen and hyaluronic acid considering their molecular structural features, thereby significantly improving quality and reliability of products, thus meeting a variety of user or customer needs to present a good image.

Description

technical field [0001] The present invention relates to a biomaterial material whose rubbery physical properties are strengthened through the natural cross-linking of collagen and hyaluronic acid, and a method for producing and using the same. The mixing ratio and the natural cross-linking conditions of non-chemical or physical cross-linking create a new material that exhibits rubber characteristics, thereby greatly improving the quality and reliability of the product and meeting the various needs of users, that is, consumers. , so as to leave a good experience. Background technique [0002] As we all know, collagen and hyaluronic acid are currently the most widely used materials as materials applicable to the living body. [0003] The aforementioned collagen is a structural protein constituting skin, tendons, blood vessels, bones, cartilage, intervertebral discs, and the like. Collagen is widely used as tissue engineering materials such as bone graft materials, wound dres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/20A61L27/56
CPCA61L27/20A61L27/24A61L27/56A61L2430/02A61L2430/12A61L27/26A61P17/02A61P19/08A61P43/00A61K31/728A61K8/65A61K8/735A61K2800/91A61Q19/08C08L5/08C08L89/06A61K2300/00A61L2430/00A61L2300/252A61L2300/236A61L26/0023A61L26/0033A61L26/0052A61L26/0085A61L26/009A61L27/365A61L27/58A61L2300/418A61L2300/604A61L2400/06A61L2430/34
Inventor 柳志喆吕世根李明圣李准根高畅权徐东三张晶皓
Owner SEWON CELLONTECH CO LTD
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