Spectrum SPR imaging sensing system based on acousto-optic light filtration
A sensing system, acousto-optic technology, applied in the field of spectral SPR imaging sensing system, can solve the problems of limited sensitivity of SPR imaging sensor, uniformity of illumination beam, reduced detection speed, etc., to facilitate industrial self-integration application, measurement The effect of high accuracy and sensitivity and fast measurement rate
Inactive Publication Date: 2016-06-29
ZHONGBEI UNIV
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Problems solved by technology
However, the sensitivity of single-wavelength SPR imaging sensors is limited by stray light and the uniformity of the illumination beam, etc.
The spectral SPR imaging sensor implemented with a monochromator improves the sensitivity of the SPR imaging sensor with single-wavelength illumination, but at the same time reduces the detection speed
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[0026] The following embodiments will further describe the present invention in conjunction with the accompanying drawings.
[0027] Such as figure 1 As shown, a spectral SPR imaging sensing system based on acousto-optic filtering, the structure of the spectral SPR imaging sensing system mainly includes: a wide-spectrum light source 1, a light beam composed of a first lens 2, an aperture 3 and a second lens 4 Reshaping collimation system, Acousto-optic Tunable Filter (AOTF) 5, AOTF RF driver 6, polarizer 7, shading plate 8, coupling prism 9 and biosensor chip 11 are matched by refractive index matching liquid 10 The core components of the SPR sensor consist of an imaging lens 12, an area array imaging CCD 13 and a control computer 14. The invention introduces AOTF spectral imaging technology on the basis of traditional SPR imaging, and then realizes spectral SPR imaging sensing detection.
[0028] The light emitted by the wide-spectrum light source 1 (usually a tungsten-halo...
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Abstract
The invention relates to the field of biochemical sensing detection, in particular to a spectral SPR imaging sensing system based on acousto-optic filtering; the spectral SPR imaging system and method realize spectral imaging based on an acousto-optic tunable filter AOTF, and use SPR imaging The principle realizes sensing; after the wide-spectrum light source passes through the beam shaping and collimating system, it enters the AOTF to realize light filtering, and enters the SPR sensing core component composed of a coupling prism and a biosensor chip through a refractive index matching liquid matching connection. Array imaging CCD realizes imaging; the present invention introduces AOTF spectral imaging technology on the basis of traditional SPR imaging, and then realizes spectral SPR imaging sensing detection. Throughput and high-sensitivity sensing and detection advantages.
Description
technical field [0001] The invention relates to the field of biochemical sensing and detection, in particular to a spectral SPR imaging sensing system based on acousto-optic filtering. It has the advantages of real-time, label-free, high-throughput and high-sensitivity sensing and detection. Background technique [0002] Surface plasmon resonance (Surface plasmon resonance, SPR) is usually excited by the evanescent wave at the boundary of the transmissive metal film layer. According to the metal film layer and the bound analyte molecules, the incident light of different wavelengths has different SPR resonance angles. The analyte molecules bound to the surface of the metal film of the SPR sensor cause a change in the refractive index of the surface. By measuring this change through the SPR principle, information such as molecular kinetics and concentration can be obtained, so as to understand the interaction between molecules. In recent years, sensors fabricated using the S...
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Login to View More IPC IPC(8): G01N21/63G01N21/01
CPCG01N21/63G01N21/01G01N2201/067
Inventor 李克武李晋华王志斌张瑞薛瑞陈友华
Owner ZHONGBEI UNIV