Application of SecinH3 to preparation of medicine for inhibiting gastric acid secretion

A 1.secinh3, gastric acid secretion technology, applied in the direction of drug combination, digestive system, etc., can solve problems such as rebound and increase of gastric acid

Inactive Publication Date: 2016-07-06
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this class of drugs is effective in most patients, the acid rebound phenomenon and tolerance after drug withdrawal are two major disadvantages

Method used

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  • Application of SecinH3 to preparation of medicine for inhibiting gastric acid secretion
  • Application of SecinH3 to preparation of medicine for inhibiting gastric acid secretion
  • Application of SecinH3 to preparation of medicine for inhibiting gastric acid secretion

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0025] SecinH3 administration method: C57 mice were treated with SecinH3 (ab145048 from abcam company), the injection method of SecinH3 was 0.1 mg / kg body weight, intraperitoneal injection 2 times a day, for 5 consecutive days. The control group was injection of equal volume of SecinH3 solvent 50% DMSO. Ten 7-8 week old mice per group. After 5 days, the mice in both groups were fasted for 24 hours and subcutaneously injected with 2 mg / kg histamine. After 30 minutes, the mice were anesthetized with 10% chloral hydrate, the cardia and pylorus were ligated, and gastric tissue was collected with 2 ml of normal saline. Gastric juice was centrifuged at 1500rpm for 10 minutes, and the supernatant was taken to measure gastric acid pH. The result is as figure 1 As shown, after SecinH3 treatment, under the stimulation of histamine, the secretion of gastric aci...

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Abstract

The invention relates to the application of SecinH3 in the preparation of drugs for inhibiting gastric acid secretion, and belongs to the technical field of new drug applications. The present invention finds through mice in vivo experiments that SecinH3 has a significant inhibitory effect on gastric acid secretion, so SecinH3 can be used to prepare drugs for inhibiting gastric acid secretion, and is effective for chronic gastritis, gastric ulcer, reflux esophagitis and duodenal ulcer, etc. Diseases related to gastric hypersecretion have good therapeutic application prospects. The present invention also verifies the role of the interconversion of Arf6-GTP and Arf6-GDP in gastric acid secretion by constructing an ASAP3 gene knockout mouse model, and provides a possible mechanism for SecinH3 to inhibit gastric acid secretion from the molecular biology level.

Description

technical field [0001] The present invention relates to a new application of compound SecinH3, in particular to the application of SecinH3 in the preparation of drugs for inhibiting gastric acid secretion. Background technique [0002] The increase or decrease of gastric acid secretion can cause a variety of common diseases of the upper gastrointestinal tract, such as increased gastric acid promotes the occurrence of reflux esophagitis. Proton pump inhibitor (PPI) drugs are currently the main drugs against hyperacidity, including omeprazole, pantoprazole, esomeprazole, etc. Clinically, they are also used in combination with antibiotics to eradicate Helicobacter pylori infection. The target of this class of drugs is the proton pump, also known as H,K-ATPase, located on the secretory tubule at the top of the parietal cell. Although these drugs are effective in the majority of patients, acid rebound after drug withdrawal and tolerance are two major drawbacks. It has been rep...

Claims

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Application Information

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IPC IPC(8): A61K31/4196A61P1/04
CPCA61K31/4196
Inventor 房静远许杰钱缙
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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